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AB153865

Anti-ZSCAN4 antibody

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(1 Publication)

Rabbit Polyclonal ZSCAN4 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ZSCAN4 aa 1-300.

View Alternative Names

ZNF494, ZSCAN4, Zinc finger and SCAN domain-containing protein 4, Zinc finger protein 494

1 Images
Western blot - Anti-ZSCAN4 antibody (AB153865)
  • WB

Unknown

Western blot - Anti-ZSCAN4 antibody (AB153865)

10% SDS PAGE

All lanes:

Western blot - Anti-ZSCAN4 antibody (ab153865) at 1/1000 dilution

All lanes:

PC-3 whole cell lysate at 30 µg

Predicted band size: 48 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human ZSCAN4 aa 1-300. The exact immunogen used to generate this antibody is proprietary information.

Q8NAM6

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ZSCAN4 also known as Zinc finger and SCAN domain-containing protein 4 plays a mechanical role in telomere maintenance and genomic stability. It has a molecular mass of approximately 55 kDa. Scientists observe ZSCAN4 expression mainly in embryonic stem cells and germ cells. The protein contains a SCAN domain and several zinc finger motifs that facilitate its binding to specific DNA sequences playing an important role in telomere elongation and genomic stability.
Biological function summary

ZSCAN4 connects to mechanisms vital for proper chromosome segregation and DNA repair. It also participates in the amplification of telomere repeats a process key for maintaining telomere length. ZSCAN4 can associate with complexes involved in chromatin remodeling and genomic reprogramming. Its function proves essential for the self-renewal and differentiation of pluripotent stem cells aiding the long-term maintenance of telomere integrity.

Pathways

ZSCAN4 integrates into the telomere extension and genomic stabilization pathways. Telomerase-related protein complexes interact with ZSCAN4 promoting telomere lengthening which slows down aging processes in cells. Additionally ZSCAN4 connects with the DNA repair machinery pathways that function to fix DNA damage and maintain genome integrity. Collaboration with proteins like TERT (Telomerase Reverse Transcriptase) and those in the SIRT (Sirtuin) family emphasize its cooperation in telomere biology and genomic stability.

ZSCAN4 has implications in cancer and age-related pathologies. Abnormal activation or suppression of ZSCAN4 leads to chromosomal instability a factor linked to cancer progression. In specific cancer types ZSCAN4 helps in bypassing senescence promoting indefinite cell proliferation. Furthermore researchers link ZSCAN4 activity to age-related disorders due to its role in telomere dynamics. In these contexts abnormalities in ZSCAN4 function often involve partnerships with proteins such as TERT and p53 which are key to telomere biology and tumor suppression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity).
See full target information ZSCAN4
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature metabolism 5:765-776 PubMed37198474

2023

Salvage of ribose from uridine or RNA supports glycolysis in nutrient-limited conditions.

Applications

Unspecified application

Species

Unspecified reactive species

Owen S Skinner,Joan Blanco-Fernández,Russell P Goodman,Akinori Kawakami,Hongying Shen,Lajos V Kemény,Lena Joesch-Cohen,Matthew G Rees,Jennifer A Roth,David E Fisher,Vamsi K Mootha,Alexis A Jourdain
View all publications
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Product promise

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