Rabbit Polyclonal ZSCAN4 antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human ZSCAN4 aa 1-300.
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Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 78.99% PBS, 20% Glycerol (glycerin, glycerine), 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human ZSCAN4 aa 1-300. The exact immunogen used to generate this antibody is proprietary information. Database link Q8NAM6
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
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Target data
Function
Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity).
Alternative names
ZNF494, ZSCAN4, Zinc finger and SCAN domain-containing protein 4, Zinc finger protein 494
Recommended products
Rabbit Polyclonal ZSCAN4 antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human ZSCAN4 aa 1-300.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 78.99% PBS, 20% Glycerol (glycerin, glycerine), 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human ZSCAN4 aa 1-300. The exact immunogen used to generate this antibody is proprietary information. Database link Q8NAM6
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
ZSCAN4 also known as Zinc finger and SCAN domain-containing protein 4 plays a mechanical role in telomere maintenance and genomic stability. It has a molecular mass of approximately 55 kDa. Scientists observe ZSCAN4 expression mainly in embryonic stem cells and germ cells. The protein contains a SCAN domain and several zinc finger motifs that facilitate its binding to specific DNA sequences playing an important role in telomere elongation and genomic stability.
- Biological function summary
ZSCAN4 connects to mechanisms vital for proper chromosome segregation and DNA repair. It also participates in the amplification of telomere repeats a process key for maintaining telomere length. ZSCAN4 can associate with complexes involved in chromatin remodeling and genomic reprogramming. Its function proves essential for the self-renewal and differentiation of pluripotent stem cells aiding the long-term maintenance of telomere integrity.
- Pathways
ZSCAN4 integrates into the telomere extension and genomic stabilization pathways. Telomerase-related protein complexes interact with ZSCAN4 promoting telomere lengthening which slows down aging processes in cells. Additionally ZSCAN4 connects with the DNA repair machinery pathways that function to fix DNA damage and maintain genome integrity. Collaboration with proteins like TERT (Telomerase Reverse Transcriptase) and those in the SIRT (Sirtuin) family emphasize its cooperation in telomere biology and genomic stability.
- Associated diseases and disorders
ZSCAN4 has implications in cancer and age-related pathologies. Abnormal activation or suppression of ZSCAN4 leads to chromosomal instability a factor linked to cancer progression. In specific cancer types ZSCAN4 helps in bypassing senescence promoting indefinite cell proliferation. Furthermore researchers link ZSCAN4 activity to age-related disorders due to its role in telomere dynamics. In these contexts abnormalities in ZSCAN4 function often involve partnerships with proteins such as TERT and p53 which are key to telomere biology and tumor suppression.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-ZSCAN4 antibody (ab153865)
10% SDS PAGE
All lanes: Western blot - Anti-ZSCAN4 antibody (ab153865) at 1/1000 dilution
All lanes: PC-3 whole cell lysate at 30 µg
Predicted band size: 48 kDa
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