Rabbit Polyclonal ZSWIM6 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ZSWIM6 aa 600-700.
Images
Publications
Filter by
- American journal of human genetics 95:235-402014Exome sequencing identifies a recurrent de novo ZSWIM6 mutation associated with acromelic frontonasal dysostosis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJoshua D Smith,Anne V Hing,Christine M Clarke,Nathan M Johnson,Francisco A Perez,Sarah S Park,Jeremy A Horst,Brig Mecham,Lisa Maves,Deborah A Nickerson,Michael L CunninghamPubMed 25105228
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human ZSWIM6 aa 600-700. The exact immunogen used to generate this antibody is proprietary information. Database link Q9HCJ5
Reactivity data
Select an application| IHC-P | ICC/IF | |
|---|---|---|
| Human | Tested | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/50.00000 - 1/200.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.25000-2.00000 µg/mL | Notes - |
Target data
Function
involved in nervous system development, important for striatal morphology and motor regulation.
Alternative names
KIAA1577, ZSWIM6, Zinc finger SWIM domain-containing protein 6
Recommended products
Rabbit Polyclonal ZSWIM6 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ZSWIM6 aa 600-700.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human ZSWIM6 aa 600-700. The exact immunogen used to generate this antibody is proprietary information. Database link Q9HCJ5
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
ZSWIM6 also known as Zinc Finger SWIM-type Containing 6 is a protein weighing approximately 117 kDa. This protein contains zinc finger motifs which facilitate its interaction with DNA or other proteins. Recognizing it by its SWIM domain one can find it highly expressed in the brain and other tissues suggesting a role in diverse cellular functions. Its distinct expression pattern indicates its involvement in specific cellular processes such as development and signaling within the nervous system.
- Biological function summary
ZSWIM6 participates in developmental processes and possibly influences neuronal activity. As part of specific protein complexes it may interact with DNA and other regulatory proteins to mediate gene expression affecting cellular development and function. Its functionality in growth and neuron communities highlights its potential role in brain development and morphology.
- Pathways
ZSWIM6 associates with pathways involved in neurodevelopment like the Wnt signaling pathway influencing cell growth differentiation and migration. It links with other proteins such as Dishevelled (DVL) involved in the Wnt pathway. Another related pathway is the mitogen-activated protein kinase (MAPK) pathway which also has a critical role in transmitting signals from receptors on the cell surface to the DNA in the nucleus affecting cellular responses.
- Associated diseases and disorders
ZSWIM6 has connections to neurological disorders such as autism spectrum disorders and intellectual disabilities. Its mutations or dysregulation can disrupt normal brain development and function. It also shows a relationship with proteins like SHANK3 which are implicated in synaptic function and disorders like autism. This association highlights its importance in maintaining neuronal connectivity and proper cognitive function.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
2 product images
Immunocytochemistry/ Immunofluorescence - Anti-ZSWIM6 antibody (ab122301)
Immunofluorescent staining of Human cell line A-431 shows positivity in cytoplasm. Recommended concentration of ab122301 1-4 µg/ml. Cells treated with PFA/Triton X-100.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZSWIM6 antibody (ab122301)
ab122301, at 1/75, staining ZSWIM6 in paraffin embedded Human smooth muscle tissue by Immunohistochemistry.
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com