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Alzheimer's imaging, simplified

Discover our solutions, comprising primary antibodies (chimeric, conjugated, and carrier-free), secondary antibodies, and dyes.

alzheimers research

Recombinant antibodies

Browse our curated portfolio of precise recombinant antibodies detecting Tau, Beta-amyloid, and other Alzheimer’s targets of interest. Our antibodies are extensively validated in multiple applications and species, as well as in Alzheimer's tissue samples so you can trust in your results.

Many of our recombinant antibodies are now available in 20 μL sample sizes.

Product highlights

Tau

Target
Recommended product
Species
Applications
Total Tau
Anti-Tau antibody [EP2456Y] (ab76128)
Human, mouse, rat
IHC-P
Total Tau
Anti-Tau antibody [TAU-5] - BSA and Azide free (ab80579)
Human, mouse, rat
ICC/IF, WB
Tau MBD region
Anti-Tau (MBD region) antibody [EPR25205-233] (ab308439)
Human, mouse, rat
IHC-P
Phospho T205
Anti-Tau (phospho T205) antibody [EPR23505-13] (ab254410)
Human, rat
IHC-P
Phospho T231
Anti-Tau (phospho T231) antibody [EPR2488] (ab151559)
Human, mouse, rat
IHC-P
Phospho S396
Anti-Tau (phospho S396) antibody [EPR2731] (ab109390)
Human, mouse, rat
IHC-P
Conformation-specific Tau
Anti-Tau Alzheimer’s Disease antibody [GT-38] - Conformation-Specific (ab246808)
Human
IHC-P

Tau interactive tool

Browse premium antibodies to Tau's domains and modified sites
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Beta-amyloid

Target
Recommended product
Human brain specificity shown by IHC
AD mouse model specificity shown by IHC
Species
Applications
Aggregated beta-amyloid fibrils
Anti-Amyloid Fibril antibody [mOC22] - Conformation-Specific (ab205339)
Frontal cortex plaques
Layer V cortical and CA1 pyramidal neurons
Human
IHC-P, Dot
Aggregated beta-amyloid (residues 2-6)
Anti-beta Amyloid antibody [mOC23] - Conformation-Specific (ab205340)
Subset of frontal cortex plaques
Hippocampal plaques
Human
IHC-P, Dot
Vascular beta-amyloid
Anti-vascular Amyloid 1-42 antibody [mOC31] - Conformation-Specific (ab201059)
Vascular amyloid deposits
Human, mouse
Dot, IHC-FrFl, IHC-P
Beta-amyloid (residues 3-6)
Anti-beta Amyloid 1-42 antibody [mOC64] (ab201060)
Frontal cortex plaques
Human, mouse, rat
IHC-P, Dot, IHC-FrFl
Aggregated beta-amyloid (residues 8-11)
Anti-Amyloid Fibril antibody [mOC78] - Conformation-Specific (ab205341)
Intracellular/nuclear, frontal cortex plaques
Layer V cortical plaques
Human
IHC-P, Dot
Amyloid fibrils
Anti-Amyloid Fibril antibody [mOC87] - Conformation-Specific (ab201062)
Frontal cortex plaques
Layer V cortical neurons (intracellular deposits)
Human, mouse
IHC-P, IHC-FrFl, Dot
Conformation-specific beta-amyloid
Anti-beta Amyloid 1-42 antibody [mOC98] - Conformation-Specific (ab201061)
Frontal cortex plaques
Layer V cortical neurons (intracellular deposits)
Human, mouse
IHC-P, Dot

Browse our full beta-amyloid range

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Other Alzheimer's disease targets

Target
Recommended product
Species
Applications
TDP-43
Anti-TDP43 antibody [EPR5810] (ab109535)
Human, mouse, rat
Flow Cyt (Intra), ICC/IF, IHC-Fr, IHC-P, WB
β-secretase/BACE1
Anti-BACE1 antibody [EPR19523] (ab183612)
Human, mouse, rat
IHC-Fr, IHC-P, IP, WB
APOE4
Anti-Apolipoprotein E4 antibody [EPR24181-64] (ab279714)
Human
Flow Cyt (Intra), ICC/IF, IHC-Fr, IHC-P, IP, WB
SV2A
Anti-SV2A antibody [EPR23500-32] (ab254351)
Human, mouse, rat
Dot, Flow Cyt (Intra), ICC/IF, IHC-Fr, IHC-P, IP, WB
SORLA/SORL1
Anti-SorLA/SORL1 antibody [EPR23262-4] (ab302508)
Human, mouse, rat
ICC/IF, IHC-Fr
TREM2
Anti-TREM2 antibody [EPR26209-22] (ab318262)
Human
IHC-P, IP, WB, mIHC
Neurofilament light/NEFL
Anti-68kDa Neurofilament/NF-L antibody [EPR22035-112] (ab223343)
Human, mouse, rat
I-ELISA, ICC/IF, IHC-Fr, IHC-P, IP, WB
Presenilin-1/PSEN1
Anti-Presenilin 1/PS-1 antibody [EP2000Y] (ab76083)
Human, mouse, rat
IHC-P, WB
Presenilin-2/PSEN2
Anti-Presenilin 2/AD5 antibody [EP1515Y] (ab51249)
Human, mouse, rat
Flow Cyt (Intra), ICC/IF, IHC-P, IP, WB
SNAP25
Anti-SNAP25 antibody [EPR3275] (ab109105)
Human, mouse, rat
Flow Cyt (Intra), ICC/IF, IHC-P, IP, WB
Neuromodulin/GAP-43
Anti-GAP43 antibody [EP890Y] - Neuronal Marker (ab75810)
Human, mouse, rat
Flow Cyt (Intra), ICC/IF, IHC-P, IP, WB
Neurogranin
Anti-Neurogranin antibody [EPR21152] (ab217672)
Human, mouse, rat
ICC/IF, IHC-Fr, IHC-P, IP, WB
IL1-β
Anti-IL-1 beta antibody [EPR21086] (ab216995)
Human
ICC/IF, IP, WB

Other key cell and neuronal markers

Target
Marker type
Recommended product
Species
Applications
MAP2
Mature neuron marker
Anti-MAP2 antibody [EPR19691] - Neuronal Marker (ab183830)
Human, mouse, rat
ICC/IF, IHC-Fr, Flow Cyt (Intra), IHC-P
NeuN
Mature neuron marker
Anti-NeuN antibody [EPR12763] - Neuronal Marker (ab177487)
Mouse, rat, human, zebrafish, common marmoset, dog, cat, goat, sheep
WB, mIHC, ICC/IF, IHC-Fr, Flow Cyt (Intra), IHC (PFA fixed), IHC-P
Beta-3-tubulin
Immature neuron marker
Anti-beta III Tubulin antibody [2G10] - Neuronal Marker (ab78078)
Mouse, dogfish, catshark, common marmoset, rat, human
IHC-P, ICC/IF, IP, Flow Cyt (Intra), WB
GFAP
Astrocyte
Anti-GFAP antibody [EPR1034Y] - Astrocyte Marker (ab68428)
Human, mouse, rat
Flow Cyt (Intra), ICC/IF, IHC-Fr, IHC-P, IP, WB, mIHC
S100 beta
Astrocyte
Anti-S100 beta antibody [EP1576Y] - Astrocyte Marker (ab52642)
Human, mouse, rat
ICC/IF, IHC-Fr, IHC-P, WB
Iba1
Microglia
Anti-Iba1 antibody [EPR16588] (ab178846)
Human, mouse, rat
IHC-Fr, WB, ICC/IF, Flow Cyt (Intra), IHC-P
TMEM119
Microglia
Anti-TMEM119 antibody [28-3] - Microglial marker (ab209064)
Mouse
IHC-FoFr, IHC-P, IHC-Fr
Synaptophysin
Synaptic marker
Anti-Synaptophysin antibody [YE269] - Synaptic Marker (ab32127)
Human, mouse, rat
ICC/IF, IHC-P, WB
Synapsin-1
Synaptic marker
Anti-Synapsin I antibody [EPR23531-50] - Synaptic Marker (ab254349)
Human, mouse, rat
Flow Cyt (Intra), ICC/IF, IHC-Fr, IHC-P, IP, WB, mIHC
MBP
Oligodendrocyte marker
Anti-Myelin Basic Protein antibody [12] (ab7349)
Human, mouse, rat
IHC-P, WB, ICC/IF
MKI67
Proliferation marker
Anti-Ki67 antibody [SP6] (ab16667)
Human, mouse, rat
mIHC, ICC/IF, WB, IHC-P, Flow Cyt (Intra)

Learn more about our Alzheimer's antibodies

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Conjugated antibodies

Directly conjugated antibodies remove the need for secondary antibodies, saving you valuable hands-on time. We offer a wide range of conjugates, including various fluorescent and chromogenic options. Fluorescent conjugated antibodies are the ideal tools for multiplex IHC. Our range of conjugates includes Alexa Fluor® dyes, biotin, HRP, AP, FITC, PE, PerCP, APC, and tandem dyes.

Our datasheets feature all available conjugates for an antibody, including the fluorescent color.

Target
Clone
Product name
Available conjugations
NeuN
EPR12763
Anti-NeuN antibody [EPR12763] - Neuronal Marker
AF488, AF555, AF568, AF594, FITC, Biotin
Tau
GT-38
Anti-Tau Alzheimer’s Disease antibody [GT-38] - Conformation-Specific
AF488, AF555, AF594, AF647
SV2A
EPR23500-32
Anti-SV2A antibody [EPR23500-32]
AF488, AF647
Tau phospho S396
EPR2731
Anti-Tau (phospho S396) antibody [EPR2731]
AF488AF555AF568AF594AF647, Biotin
Tau phospho T205
EPR23505-13
Anti-Tau (phospho T205) antibody [EPR23505-13]
AF488AF555, AF594, AF647, AF750, Biotin, APC, PE
APOE4
EPR24181-64
Anti-Apolipoprotein E4 antibody [EPR24181-64]
AF488AF555, AF594, AF647, AF750, PE, APC
beta Amyloid 1-42
mOC64
Anti-beta Amyloid 1-42 antibody [mOC64]
AF488, AF555, AF568, AF647
Iba1
EPR16588
Anti-Iba1 antibody [EPR16588]
AF488, AF647, AF750, APC
GFAP
EPR1034Y
Anti-GFAP antibody [EPR1034Y] - Astrocyte Marker
AF405, AF488AF555, AF568, AF594, AF647PE, APC, HRP, Alkaline phosphatase, Biotin
MAP2
EPR19691
Anti-MAP2 antibody [EPR19691] - Neuronal Marker
AF488, AF555AF568, AF594, AF647
SYP
YE269
Anti-Synaptophysin antibody [YE269] - Synaptic Marker
AF488, AF555AF594, AF647HRP
PSD95
EPR23124-118
Anti-PSD95 antibody [EPR23124-118] - Synaptic Marker
AF555AF568, AF647
Cathepsin D
EPR3057Y
Anti-Cathepsin D antibody [EPR3057Y]
AF405AF488, AF555, AF568, AF594, AF647, AF750, PE, APCHRP
a-Synuclein
MJFR1
Anti-Alpha-synuclein antibody [MJFR1]
Biotin, HRP
NFL
EPR22035-112
Anti-68kDa Neurofilament/NF-L antibody [EPR22035-112]
AF488, AF555, AF647
GAP43
EP890Y
Anti-GAP43 antibody [EP890Y] - Neuronal Marker
AF647, HRP, PE

"AF" denotes Alexa Fluor®, a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company.

Chimeric antibodies

Developed using recombinant technology, our chimeric antibodies combine the high specificity and sensitivity of our trusted rabbit monoclonal antibodies with constant regions (Fc) from alternative host species, including mouse, rat, goat, and chicken. This innovative design preserves the binding performance of the original clone while enabling seamless integration into multiplexed assays.

Learn more

Product highlights

Target
Clone number
Product name
Available isotypes
GFAP
EPR1034Y
Anti-GFAP antibody [EPR1034Y]
Rabbit IgG, Goat IgG, Chicken IgY, Mouse IgG1, Mouse IgG2a, Rat IgG2a
Iba1
EPR16588
Anti-Iba1 antibody [EPR16588]
Rabbit IgG, Goat IgG, Chicken IgY, Rat IgG2a
Iba1
EPR16589
Anti-Iba1 antibody [EPR16589]
Rabbit IgG, Mouse IgG1, Rat IgG2a
MAP2
EPR19691
Anti-MAP2 antibody [EPR19691]
Rabbit IgG, Goat IgGChicken IgY, Mouse IgG2a
Tau
EPR22524-95
Anti-Tau antibody [EPR22524-95]
Rabbit IgG, Mouse IgG1
Tau
E178
Anti-Tau (phospho S396) antibody [E178]
Rabbit IgG, Mouse IgG2a
SYP
YE269
Anti-Synaptophysin antibody [YE269] - Mouse IgG1 (Chimeric)
Rabbit IgG, Mouse IgG1
PSD95
EPR23124-118
Anti-PSD95 antibody [EPR23124-118]
Rabbit IgG, Goat IgG
a-Synuclein
MJFR1
Anti-Alpha-synuclein antibody [MJFR1]
Rabbit IgG, Mouse IgG2a
RAB10
MJF-R23
Anti-RAB10 antibody [MJF-R23]
Rabbit IgG, Mouse IgG2a
RAB10
MJF-R21
Anti-RAB10 (phospho T73) antibody [MJF-R21]
Rabbit IgG, Mouse IgG2a
UBC
30H3/30K1
Anti-Ubiquitin (phospho S65) antibody [30H3/30K1]
Rabbit IgG, Rat IgG2a
VCP
Z-VCP-10
Anti-VCP antibody [Z-VCP-10]
Rabbit IgG, Mouse IgG2a
Cathepsin D
EPR3057Y
Anti-Cathepsin D [EPR3057Y]
Rabbit IgG, Chicken IgYMouse IgG2a

Browse our full range of chimeric antibodies

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Accessory reagents

To support your experiments, we offer a broad range of accessory reagents, including secondary antibodies, dyes and inhibitors.

Dyes to visualize amyloid

Secondary antibodies

See all our secondary antibodies

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Fc-specific pre-adsorbed secondary antibodies

See all our Fc-specific secondary antibodies

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Sample preparation and detection kits

Application
Product name
Note
Tissue clearing – CUBIC
Tissue Clearing Kit – CUBIC
Tissue clearing for 3D tissue imaging using CUBIC protocols
Tissue staining – CUBIC
3D Tissue Staining Kit – CUBIC
3D tissue imaging
Tissue Clearing – hydrophobic
Tissue Clearing Kit  - hydrophobic
Tissue clearing for 3D tissue imaging using hydrophobic sample treatment
DNA labeling
DAPI Staining Solution
IHC staining
DAB Substrate Kit
IHC staining
Mouse and Rabbit Specific HRP/DAB Detection IHC kit
IHC staining
Mouse on Mouse Polymer IHC Kit

View our full range of IHC kits

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Webinar: The role of astrocytes in Alzheimer's disease

Learn more about the role of astrocytes in AD and other neurogenerative diseases from Assistant Professor Shane Liddelow from the Department of Neuroscience and Physiology at NYU Langone Medical Center.

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Webinar: Inflammation in Alzheimer's disease

Discover the critical role of inflammation in Alzheimer’s disease in this expert-led webinar featuring Professor Michael Heneka.

Watch now

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