Cell and gene therapy solutions
Accelerate your cell and gene therapy discovery workflow with our comprehensive collection of high-quality assays and reagents. Our offerings include immunoassays for profiling inflammatory factors and viral vector titration, alongside assays for cell viability and proliferation. Whether you're working on cellular characterization or functional studies, our tools ensure precision and reliability at every step of your research.
Enhance your flow cytometry analysis with our wide selection of antibodies for accurate cellular phenotyping and induce T cell activation and expansion with our rigorously tested recombinant proteins. Our products are designed to support the unique demands of your cell and gene therapy research, allowing you to confidently achieve consistent, high-performance results.
Immunoassays
Immunoassays are a pivotal tool to ensure successful cell and gene therapy development. In cell therapy, immunoassays are used to monitor the expression and secretion of therapeutic markers and signaling molecules, ensuring that the cells exhibit the desired properties and perform optimally. In gene therapy, these kits are crucial for viral vector titration, allowing researchers to determine the concentration of viral particles and ensure the potency and purity of vector preparations.
From quantification of cytokine release to viral vector titration, our SimpleStep ELISA kits generate data in 90 minutes. With only one wash step, streamline your workflow without compromising quality and performance. Some of our SimpleStep are also available in 384-well format to scale up your experiment.
We also offer other immunoassays such as ELIspot kits to assess T cell activation or measure host cell proteins (HCPs) and ELISA kits to measure residual HCPs.
Product highlights
HIV1 p24 ELISA Kit- Extracellular
- 90 min SimpleStep ELISA kit
- Simple workflow for viral vector titration
- Available in 384-well format for higher throughput
Human IFN gamma ELISA Kit
- 90 min SimpleStep ELISA kit
- Simple workflow
- Available in 384-well format for higher throughput
Human TNF alpha ELISA Kit
- 90 min SimpleStep ELISA kit
- Simple workflow
- Available in 384-well format for higher throughput
Cell viability / cell proliferation assays
Cell viability and cell proliferation assays are essential tools in the discovery and development of cell therapies.
Cell viability assays measure the proportion of living cells within a population, providing insights into the cytotoxic effects of various compounds or environmental conditions. Cell proliferation assays assess the rate at which cells divide and multiply, offering valuable data on the growth dynamics of therapeutic cells. Together, these assays ensure that the cells used in your assays are both viable and capable of effective proliferation, ultimately allowing reliable assessment of the safety and efficacy of novel cell-based treatments.
We offer an extended range of highly cited, easy-to-use cell viability and cell proliferation assays in different size formats to fit your needs. The assays are readout using the most commonly available types of flow cytometers, plate readers, fluorescence microscopes, and other instrumentation.
Product highlights
Cell Counting Kit 8 (WST-8 / CCK8)
- Recombinant rabbit monoclonal antibody
- Validated in flow cytometry
- Also available in carrier-free format for optimal conjugation
MTS Assay Kit (Cell Proliferation) (Colorimetric)
- Recombinant rabbit monoclonal antibody
- Validated in flow cytometry
- Also available in carrier-free format for optimal conjugation
LDH Assay Kit (Cytotoxicity)
- Highly cited (over 140 publications)
- Easy-to-use no-wash assay
- Only one 30-min incubation step
Flow cytometry antibodies
Flow cytometry-validated antibodies play a pivotal role in cell therapy discovery by enabling the precise identification and characterization of specific cell populations. These antibodies are designed to bind to unique surface markers on cells, so you can analyze, and sort various cell types based on their distinct characteristics.
You can also assess the purity, viability, and functionality of cells, ensuring that only the relevant cell populations are selected for further development and analysis. This facilitates the advancement of targeted cell therapies, enhancing their efficacy and safety for clinical applications.
Our portfolio of highly sensitive and specific recombinant monoclonal antibodies can be used in CAR T cell therapy research and development, including flow cytometry-based analysis of immune and tumor cell populations and immunohistochemistry-based analysis of tissue specimens. Choose from our ever-expanding collection of antibodies conjugated to a broad range of labels, including the Alexa Fluor® range, FITC, PE, and APC. If you have specific antibody-labeling needs, you can use our quick and easy-to-use Lightning-Link® conjugation kits.
Product highlights
Anti-CD8 alpha antibody [CAL66]
- Recombinant rabbit monoclonal antibody
- Validated in flow cytometry
- Also available in carrier-free format for optimal conjugation
Anti-CD4 antibody [SP35]
- Recombinant rabbit monoclonal antibody
- Validated in flow cytometry
- Also available in carrier-free format for optimal conjugation
Anti-PD1 antibody [NAT105]
- Recombinant rabbit monoclonal antibody
- Validated in flow cytometry
Recombinant proteins
In cell therapy, proteins like growth factors and cytokines enhance cell proliferation, differentiation, and survival, optimizing the therapeutic potential of transplanted cells.
Our premium bioactive proteins are mammalian-expressed, have ultra-low endotoxin levels, and are tested for activity, purity, and identity. Our proteins are manufactured under ISO 9001:2015 standards and are consistent batch-to-batch to give you the most reliable results possible. All our proteins have robust bioactivity, making them ideal for use in cell culture media or functional studies.
Product highlights
Recombinant human TNF alpha protein (Active)
- Expressed in HEK293 cells
- >95% purity
- Ultra-low endotoxin levels (0.005 EU/µg)
Recombinant human IL-1 beta protein (Active)
- Expressed in HEK293 cells
- >95% purity
- Ultra-low endotoxin levels (0.005 EU/µg)
Recombinant human EGF protein (Active)
- Expressed in HEK293 cells
- >95% purity
- Ultra-low endotoxin levels (0.005 EU/µg)
Knockout (KO) cell lines
KO cell lines are used to investigate the impact of specific gene deletions on various cell functions. This approach facilitates the identification of potential therapeutic targets and expedites the development of novel treatments. Furthermore, KO cell lines serve as a valuable tool for evaluating the efficacy and safety of gene-editing techniques.
Our gene-edited cell lines, generated using CRISPR-Cas9 technology, precisely disrupt a specific gene within the cellular genome. These cell lines undergo extensive validation to ensure specificity, thereby enabling more rapid advancements in target validation, pathway elucidation, disease research, and related fields.
Product highlights
Human TREM2 knockout THP-1 cell line
- KO validated by Next Generation Sequencing and western blot
- Free of charge wild type control available
- Knockout achieved by CRISPR/Cas9; X = 1 bp deletion, 2 bp deletion; Frameshift: 97%.
Human MS4A1 (CD20) knockout Raji cell line
- KO validated by Next Generation Sequencing and western blot
- Free of charge wild type control available
- Knockout achieved by CRISPR/Cas9; X = 2 bp deletion; Frameshift: 100%.
Human ErbB2 / HER2 knockout MCF7 cell line
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KO validated by Next Generation Sequencing, Western blot
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Free of charge wild type control available