Premium tools for diabetes research
Diabetes is a chronic metabolic disorder characterized by elevated blood glucose levels due to inadequate insulin production or impaired insulin utilization, commonly known as insulin resistance. This dysregulation can lead to severe complications such as cardiovascular disease, kidney failure, neuropathy, and vision loss. With nearly one in nine adults, 589 million people, now living with diabetes, the global burden of this chronic disease continues to escalate. As the need for effective interventions intensifies, so does the demand for advanced research tools that can drive innovation across the diabetes research pipeline.
We collaborate with leading experts in metabolic disease to develop high-performance reagents that support every stage of discovery, from early-stage target identification and validation to late-stage clinical trials and biomarker development. Our portfolio includes highly specific antibodies, ELISA kits, and bioassays validated across key diabetes pathways, including insulin signaling, glucose metabolism, and pancreatic β-cell function.
Insulin resistance and impaired glucose metabolism are key hallmarks of diabetes, contributing to chronic hyperglycemia and a cascade of metabolic dysregulation. Understanding the molecular mechanisms of diabetes is crucial for advancing both diagnostics and therapeutic strategies, particularly in the areas of insulin resistance and glucose metabolism.
Our comprehensive selection of recombinant antibodies play a vital role in enabling researchers to dissect these complex pathways with precision and reproducibility. By targeting key biomarkers and signaling molecules involved in insulin signaling, glucose uptake, and metabolic regulation, these tools provide critical insights that drive translational research and drug discovery. We take the quality of our antibodies seriously, validation across different applications, different sample types and different platforms so you can be sure they'll work in your lab.
Product highlights
Anti-Insulin antibody [EPR17359]
- Cited in over 50 publications
- Excellent staining in pancreas tissue
- Five-star reviewed
- Detects insulin in ICC/IF, IHC-Fr, IHC-P, WB, mIHC
- Suitable for human, mouse, and rat samples
Anti-Hexokinase II antibody [EPR20839]
- Cited in over 200 publications
- Specificity confirmed with HK2 knockout cell line validation and dot blot analysis
- Detects Hexokinase II in flow cytometry (intra), ICC/IF, IHC-P, IP and western blot
- Suitable for human, mouse and rat samples
Anti-SGLT2 antibody [EPR27112-7]
- IHC staining specific to tissue type, confirmed with relevant positive (kidney) and negative (pancreas) controls
- SGLT2 specificity confirmed with overexpressing cell blocks
- Suitable for IHC-P, IHC-Fr, WB
- Reacts with mouse and rat samples
Our SimpleStep ELISA® kits are potent tools for screening multiple proteins of interest, generating data in just 90 minutes without compromising on performance. ELISA kits are essential tools in diabetes research, particularly when studying insulin signaling and glucose metabolism.
Our kits allow you to quantify specific proteins and biomarkers in biological samples with high sensitivity and specificity. By delivering robust quantitative data, they support your investigation of dysregulated pathways central to insulin signaling and glucose metabolism, key processes disrupted in diabetes.
Product highlights
Human Insulin ELISA Kit
- Single-wash 90-minute assay kit with a single wash step
- Quantifies human insulin with a sensitivity of 7.13 pmol/L
- Colorimetric sandwich ELISA with 450 nm readout: works on any standard plate reader
- Validated in heparin plasma, serum, EDTA plasma
Human IGF1 Receptor ELISA Kit
- Single-wash 90-minute assay kit with a single wash step
- Quantifies human IGF1 receptor with a sensitivity of 85 pg/mL
- Colorimetric sandwich ELISA with 450 nm readout: works on any standard plate reader
- Validated in heparin plasma, citrate plasma, serum, cell lysate, EDTA plasma
Human Hexokinase II ELISA Kit
- Single-wash 90-minute assay kit with a single wash step
- Quantifies human hexokinase II with a sensitivity of 11.37 pg/mL
- Colorimetric sandwich ELISA with 450 nm readout: works on any standard plate reader
- Validated in cell culture extracts, tissue extracts, heparin plasma, citrate plasma, serum, EDTA plasma
Biochemical assays provide a powerful means to quantify key metabolic markers and enzymes involved in glucose regulation, oxidative stress, and insulin regulation. Targets such as glucose, DPP4, and branched-chain amino acids offer direct insights into dysregulated pathways central to diabetes onset and progression.
By enabling precise measurement of these biomarkers in biological samples, our bioassays not only facilitate basic research into disease mechanisms but also support translational efforts in drug development, biomarker discovery, and therapeutic monitoring. Our premium bioassays are manufactured with strict quality control criteria in our Boston, MA life sciences hub, providing you with the reliable supply you need to scale up. Our kits feature easy to use, step by step procedures with controls and standards, and feature convenient colorimetric and fluorometric readouts.
Product highlights
Glucose Assay Kit
- Cited in over 170 publications
- Readout on any colorimetric (570 nm) or fluorometric (Ex/Em= 535/587 nm) plate reader
- Quantitative, addition-only assay with just one 30-minute incubation step
Glycogen Assay Kit
- Cited in over 135 publications
- No-wash assay with two 30-minute incubation steps
- Readout on any colorimetric (570 nm) or fluorometric (Ex/Em 535/587 nm) plate reader
Uric Acid Assay Kit
- Cited in over 30 publications
- Detects uric acid in multiple sample types: urine, plasma, tissue extracts, cell culture supernatant, serum, other biological fluids
- Readout on any fluorometric (Ex/Em 535/587 nm) or colorimetric (λ= 570 nm) plate reader
Pancreatic β-cells play a central role in metabolic regulation by producing and secreting insulin, the hormone responsible for facilitating glucose uptake into tissues such as muscle, liver, and adipose tissue. In type 2 diabetes (T2D), the progressive dysfunction of these β-cells, often in response to chronic insulin resistance and metabolic stress, leads to impaired insulin secretion and persistent hyperglycemia.
Understanding the molecular mechanisms underlying β-cell dysfunction is essential for developing therapeutic strategies aimed at preserving insulin production and maintaining glucose homeostasis. To support this critical area of research, we offer a comprehensive range of high-quality recombinant antibodies and ELISA kits specifically designed to target key biomarkers involved in β-cell health and insulin signaling. Our reagents are validated in relevant sample types and in relevant platforms to ensure compatibility and reliability, and are available across a range of applications.
Product highlights
Human C-Peptide ELISA Kit
- Single-wash 90-minute ELISA
- Quantifies human C-peptide with a sensitivity of 1.45 pg/mL
- Available in 384-well plate format for higher throughput
Anti-Insulin antibody [RM1019]
- Validated in human, mouse and rat pancreas tissue and cell lysates
- Suitable for I-ELISA, IHC-P, ICC/IF, IP, WB, IHC-Fr, flow cyt (intra)
- Reacts with human, mouse, and rat samples
- Cell-type-specific staining confirmed with relevant positive (Beta-TC-6 cell line) and negative (C2C12 cell line) controls
Anti-PDX1 antibody [EPR22002]
- Validated in human, mouse and rat pancreas tissues
- Suitable for IHC-P, IP, WB, ICC/IF
- Reacts with mouse, rat, and human samples
- Cell-type-specific staining confirmed with relevant positive (Beta-TC-6 cell line) and negative (NIH/3T3 cell line) controls
