Tools to support your multiple sclerosis research

Multiple sclerosis (MS) is a complex inflammatory disorder caused by interactions between genetic and environmental factors. This complexity results in heterogeneity in clinical expression and treatment response, driving development of personalized therapeutics to improve patient outcomes.
To better understand the underlying causes of MS and uncover novel biomarkers and therapeutic targets, you need reliable reagents to targets related to immunomodulation, demyelination and related pathways.
Move ahead in your multiple sclerosis studies with the ultimate catalog of gold-standard recombinant antibodies and immunoassays. Our industry-leading validation processes give you reagents that work first time, every time and over time so you can have confidence in your results.
Browse our curated portfolio to discover how our reagents can help you study immunomodulation, demyelination and more.
Over years of research, we have started to learn more about the important role of the immune system in the pathogenesis of MS, which involves the recurrent invasion of the brain and spinal cord by both T and B cells. Accelerate your studies of the role of the immune system in MS with our premium recombinant antibodies. Our broad range of highly reproducible, recombinant antibodies includes conjugates and carrier-free formulations for flow cytometry, so you can find the right tools to support your research.
Browse our curated range of gold-standard antibodies to key immune targets in MS, including a variety of solutions for CD20 study.
Product highlights
Anti-CD20 antibody [SP32]
- Broadly validated in all traditional applications with human, mouse and rat samples
- Knock-out validated
- Advanced validation

Anti-CD20 antibody [EP459Y] (ab78237)
- Broadly validated in all traditional applications with human samples
- Knock-out validated

Anti-CD20 antibody [EP459Y] - Mouse IgG1 (Chimeric) (ab279298)
- Engineered using recombinant technology
- Provides ultimate reliability when multiplexing with other host species

Repairing the myelin sheath is a key focus for multiple sclerosis research. Assessing disease progression and the effectiveness of repair mechanisms requires reliable antibodies that can be used in immunohistochemical analysis of brain and CNS tissue.
Assess myelin sheath integrity with our precision recombinant antibodies, broadly validated across applications including IHC. Our in-house recombinant antibodies are tested in tissue microarrays (TMA), including brain tissue samples, to ensure optimal performance in your experiments.
Product highlights
Anti-Myelin Basic Protein antibody [12] (ab7349)
- Cited in over 300 publications
- Validated in western blot, IHC-P and ICC/IF with human samples

Anti-Myelin Protein Zero antibody [EPR20383] (ab183868)
- Suitable IHC-Fr, IHC-P, western blot and IP
- Reacts with human, mouse and rat samples

Anti-MAG/GMA antibody [EPR24276-125] (ab277254)
- Suitable for ICC/IF, western blot and IHC-Fr/IP
- Reacts with human, mouse and rat samples

Our broad catalog of gold-standard reagents also includes antibodies to other established and emerging therapeutic targets in MS, including dihydroorotate dehydrogenase (DHODH), glucocorticoid receptors and sphingosine 1-phosphate receptor (S1P1/EDG1)1. We validate our antibodies across applications and reactive species, and provide both conjugated and carrier-free formats to give you ultimate flexibility.
Product highlights
Anti-COX2 / Cyclooxygenase 2 antibody [EPR12012] (ab179800)
- Cited in >100 publications
- Knock-out validated
- Suitable for IP, western blot, ICC/IF and IHC-P in human, mouse and rat samples

Anti-MMP9 antibody [RM1020] (ab283575)
- Rabbit recombinant multiclonal
- Provides the benefits of a polyclonal with the superior reproducibility of a recombinant
- Broadly validated across traditional applications
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP9 antibody [RM1020] (AB283575)

References
1.Patil, M. S. et al. Multiple sclerosis: Immune Cells, histopathology, and therapeutics. Sclerosis 2, 117–139 (2024).
Diagnosing MS is challenging and currently relies on integrating clinical findings with MRI imaging of the brain and spinal cord. However, recent years have demonstrated the value of fluid biomarkers, detected in blood or CSF, which provide additional insights into disease onset and progression1.
Get reproducible, batch-to-batch consistency using SimpleStep ELISA® kits for your biomarker research.
Our highly sensitive ELISAs deliver consistent performance while reducing assay time to 90 minutes or less. They’re powered by our premium recombinant antibodies, delivering the sensitivity and specificity your samples deserve.
Growing numbers of our kits are now available in 10-pack sizes and a 384-well format, allowing you to get 300% more from your precious samples while using only a quarter of the sample volume.
Browse ELISA kits related to key emerging biomarkers, including matrix metalloproteinase-9 (MMP-9), CHIT1, sTREM2, CXCL13, and neurofilament light chains.
Product highlights
Human MMP9 ELISA Kit (ab246539)
- Superior sensitivity relative to competing kits
- Quantitative measurement of human MMP9 in Heparin plasma, serum, saliva, cell culture extracts, tissue extracts and cell supernatant samples

Human YKL-40 ELISA Kit (ab255719)
- Validated in human CSF and blood samples
- More sensitive than our leading competitor

References
1.Di Filippo, M. et al. Fluid biomarkers in multiple sclerosis: From current to future applications. The Lancet Regional Health - Europe 44, 101009 (2024).