Tools to support your multiple sclerosis research

IgorE Abcam multiple sclerosis tools

Multiple sclerosis (MS) is a complex inflammatory disorder caused by interactions between genetic and environmental factors. This complexity results in heterogeneity in clinical expression and treatment response, driving development of personalized therapeutics to improve patient outcomes.

To better understand the underlying causes of MS and uncover novel biomarkers and therapeutic targets, you need reliable reagents to targets related to immunomodulation, demyelination and related pathways.

Move ahead in your multiple sclerosis studies with the ultimate catalog of gold-standard recombinant antibodies and immunoassays. Our industry-leading validation processes give you reagents that work first time, every time and over time so you can have confidence in your results.

Browse our curated portfolio to discover how our reagents can help you study immunomodulation, demyelination and more.

Over years of research, we have started to learn more about the important role of the immune system in the pathogenesis of MS, which involves the recurrent invasion of the brain and spinal cord by both T and B cells. Accelerate your studies of the role of the immune system in MS with our premium recombinant antibodies. Our broad range of highly reproducible, recombinant antibodies includes conjugates and carrier-free formulations for flow cytometry, so you can find the right tools to support your research.

Browse our curated range of gold-standard antibodies to key immune targets in MS, including a variety of solutions for CD20 study.

Product highlights

Target
abID
Product name
Host species
Listed applications
BTK
ab208937
Anti-BTK antibody [EPR20445]
Rabbit
IP, WB, ICC/IF, Flow Cyt (Intra), IHC-P
BTK
ab68217
Anti-BTK (phospho Y223) antibody [EP420Y]
Rabbit
IP, Dot, WB
CD20
ab64088
Anti-CD20 antibody [SP32]
Rabbit
Flow Cyt (Intra), ICC/IF, IHC-P, IP, WB, mIHC
CD20
ab310536
Alexa Fluor® 594 Anti-CD20 antibody [SP32]
Rabbit
Antibody Labelling, Target Binding Affinity
CD20
ab307132
Alexa Fluor® 488 Anti-CD20 antibody [SP32]
Rabbit
IHC-P
CD20
ab312067
Alexa Fluor® 555 Anti-CD20 antibody [SP32]
Rabbit
Antibody Labelling, Target Binding Affinity
CD20
ab78237
Anti-CD20 antibody [EP459Y]
Rabbit
Flow Cyt (Intra), ICC/IF, IHC-P, IP, WB
CD20
ab198943
Alexa Fluor® 647 Anti-CD20 antibody [EP459Y]
Rabbit
Flow Cyt (Intra), mIHC
CD20
ab198941
Alexa Fluor® 488 Anti-CD20 antibody [EP459Y]
Rabbit
Flow Cyt (Intra)
CD20
ab279298
Anti-CD20 antibody [EP459Y] - Mouse IgG1 (Chimeric)
Mouse
Mouse    Flow Cyt (Intra), ICC, IP, WB
CD40
ab213205
Anti-CD40 antibody [EPR20540]
Rabbit
IHC-P, WB
CD40
ab224639
Anti-CD40 antibody [EPR20735]
Rabbit
Flow Cyt, ICC/IF, IHC-P, IP, WB
CD40
ab302830
Alexa Fluor® 647 Anti-CD40 antibody [EPR20735]
Rabbit
Flow Cyt, ICC/IF
CD40
ab302800
Alexa Fluor® 594 Anti-CD40 antibody [EPR20735]
Rabbit
Flow Cyt, ICC/IF
CD52
ab234412
Anti-CD52 antibody [CD52/2276R
Rabbit
IHC-P
CD52
ab245681
Anti-CD52 antibody [Campath-1H]
Rabbit
Flow Cyt, IHC-P
CD58
ab196648
Anti-CD58 antibody [EP15041]
Rabbit
WB
IL-2 Receptor alpha
ab231441
Anti-IL-2 Receptor alpha antibody [SP176]
Rabbit
ICC/IF, IHC-P, WB
Interferon- Beta
ab85803
Anti-Interferon beta antibody
Rabbit
WB, ICC/IF

Complement your investigation of immunomodulation in brain and CNS tissues with our neuronal marker guide.

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Repairing the myelin sheath is a key focus for multiple sclerosis research. Assessing disease progression and the effectiveness of repair mechanisms requires reliable antibodies that can be used in immunohistochemical analysis of brain and CNS tissue.

Assess myelin sheath integrity with our precision recombinant antibodies, broadly validated across applications including IHC. Our in-house recombinant antibodies are tested in tissue microarrays (TMA), including brain tissue samples, to ensure optimal performance in your experiments.

Product highlights

Target
abID
Product name
Host species
Listed applications
CNPase
ab6319
Anti-CNPase antibody [11-5B]
Mouse
ICC/IF, WB, IHC-P
CNPase
ab227218
Anti-CNPase antibody
Rabbit
WB, IHC-P, IHC-Fr
MAG/GMA
ab277524
Anti-MAG/GMA antibody [EPR24276-125]
Rabbit
ICC/IF, IHC-Fr, IHC-P, IP, WB
MAG/GMA
ab46803
Anti-MAG/GMA antibody [EP971Y]
Rabbit
WB
Myelin Basic Protein
ab7349
Anti-Myelin Basic Protein antibody [12]
Rat
ICC/IF, IHC-P, WB
Myelin Basic Protein
ab218011
Anti-Myelin Basic Protein antibody [EPR21188]
Rabbit
IHC-Fr, IHC-P, WB
Myelin Basic Protein
ab321395
Alexa Fluor® 750 Anti-Myelin Basic Protein antibody [EPR21188]
Rabbit
Antibody Labelling, Target Binding Affinity
Myelin Basic Protein
ab311790
Alexa Fluor® 594 Anti-Myelin Basic Protein antibody [EPR21188]
Rabbit
Antibody Labelling, Target Binding Affinity
Myelin Basic Protein
ab313071
Alexa Fluor® 568 Anti-Myelin Basic Protein antibody [EPR21188]
Rabbit
Antibody Labelling, Target Binding Affinity
Myelin oligodendrocyte glycoprotein
ab233549
Anti-Myelin oligodendrocyte glycoprotein antibody [EPR22629-310]
Rabbit
IHC-Fr, IHC-P, IP, WB
Myelin oligodendrocyte glycoprotein
ab199472
Alexa Fluor® 647 Anti-Myelin oligodendrocyte glycoprotein antibody [EP4281]
Rabbit
IHC-P
Myelin Protein Zero
ab183868
Anti-Myelin Protein Zero antibody [EPR20383]
Rabbit
ICC/IF, IHC-Fr, IHC-P, IP, WB
PMP22
ab270400
Anti-PMP22 antibody [EPR23112-110]
Rabbit
Flow Cyt, ICC/IF, IHC-P, IP, WB
PMP22
ab310284
Alexa Fluor® 647 Anti-PMP22 antibody [EPR23112-110]
Rabbit
Antibody Labelling, Target Binding Affinity
PMP22
ab321532
Alexa Fluor® 750 Anti-PMP22 antibody [EPR23112-110]
Rabbit
Antibody Labelling, Target Binding Affinity
PMP22
ab312762
Alexa Fluor® 568 Anti-PMP22 antibody [EPR23112-110]
Rabbit
Antibody Labelling, Target Binding Affinity
MAG/GMA
ab277524
Anti-MAG/GMA antibody [EPR24276-125]
Rabbit
ICC/IF, IHC-Fr, IHC-P, IP, WB

Explore more of our solutions for oligodendrocyte targets with our marker guide.

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Our broad catalog of gold-standard reagents also includes antibodies to other established and emerging therapeutic targets in MS, including dihydroorotate dehydrogenase (DHODH), glucocorticoid receptors and sphingosine 1-phosphate receptor (S1P1/EDG1)1. We validate our antibodies across applications and reactive species,  and provide both conjugated and carrier-free formats to give you ultimate flexibility.

Product highlights

Target
abID
Product name
Host species
Listed applications
CDNF
ab253238
Anti-CDNF antibody [EPR22334-99]
Rabbit
IHC-P, IP, WB
COX1 / Cyclooxygenase 1
ab109025
Anti-COX1 / Cyclooxygenase 1 antibody [EPR5866]
Rabbit
Flow Cyt (Intra), ICC/IF, IHC-P, IP, WB
COX2 / Cyclooxygenase 2
ab179800
Anti-COX2 / Cyclooxygenase 2 antibody [EPR12012]
Rabbit
ICC/IF, IHC-P, IP, WB
COX2 / Cyclooxygenase 2
ab283574
Anti-COX2 / Cyclooxygenase 2 antibody [RM1026]
Rabbit
ICC/IF, IHC-P, IP, WB
Cystatin F
ab309544
Anti-Cystatin F antibody [EPR28408-30]
Rabbit
Flow Cyt (Intra), IHC-P, IP
DHODH
ab174288
Anti-DHODH antibody [EPR11814]
Rabbit
WB
EDG3/S1P3
ab126622
Anti-EDG3/S1P3 antibody [EPR4541(2)]
Rabbit
IHC-P, WB
Glucocorticoid Receptor
ab183127
Anti-Glucocorticoid Receptor antibody [EPR19621]
Rabbit
Flow Cyt (Intra), ICC/IF, IHC-P, WB
hnRNP A1
ab177152
Anti-hnRNP A1 antibody [EPR12768]
Rabbit
Flow Cyt (Intra), ICC/IF, IHC-P, WB
KCNQ3
ab302782
Anti-KCNQ3 antibody [EPR25237-57]
Rabbit
ICC/IF, IHC-Fr, IHC-P
Keap1
ab227828
Anti-Keap1 antibody [EPR22664-26]
Rabbit
IHC-P, WB
MMP9
ab76003
Anti-MMP9 antibody [EP1254]
Rabbit
Flow Cyt (Intra), ICC/IF, IHC-P, WB
MMP9
ab283575
Anti-MMP9 antibody [RM1020]
Rabbit
Flow Cyt (Intra), I-ELISA, ICC/IF, IHC-Fr, IHC-P, IP, WB
Nav1.5/SCN5A
ab300048
Anti-Nav1.5/SCN5A antibody [EPR25136-48]
Rabbit
IHC-P, WB
Nav1.8/SCN10A
ab93616
Anti-Nav1.8/SCN10A antibody [S134]
Mouse
Flow Cyt, ICC, ICC/IF, IHC-Fr, IHC-P, WB
NMDAR2A
ab124913
Anti-NMDAR2A antibody [EPR2465(2)]
Rabbit
WB
S1P1/EDG1
ab233386
Anti-S1P1/EDG1 antibody [EPR21202]
Rabbit
ICC/IF, IHC-P, WB
S1PR2
ab306562
Anti-S1PR2 antibody [EPR27141-13]
Rabbit
WB
SCN11A
ab316324
Anti-SCN11A antibody [EPR28603-66]
Rabbit
IHC-Fr, WB
SCN3A
ab309473
Anti-SCN3A antibody [EPR25135-66]
Rabbit
WB

Complement your investigation of multiple sclerosis targets with our neuronal marker guides.

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References

1.Patil, M. S. et al. Multiple sclerosis: Immune Cells, histopathology, and therapeutics. Sclerosis 2, 117–139 (2024).

Diagnosing MS is challenging and currently relies on integrating clinical findings with MRI imaging of the brain and spinal cord. However, recent years have demonstrated the value of fluid biomarkers, detected in blood or CSF, which provide additional insights into disease onset and progression1.

Get reproducible, batch-to-batch consistency using SimpleStep ELISA® kits for your biomarker research.

Our highly sensitive ELISAs deliver consistent performance while reducing assay time to 90 minutes or less. They’re powered by our premium recombinant antibodies, delivering the sensitivity and specificity your samples deserve.

Growing numbers of our kits are now available in 10-pack sizes and a 384-well format, allowing you to get 300% more from your precious samples while using only a quarter of the sample volume.

Browse ELISA kits related to key emerging biomarkers, including matrix metalloproteinase-9 (MMP-9), CHIT1, sTREM2, CXCL13, and neurofilament light chains.

Product highlights

Explore ELISA kits fully validated in CSF

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References

1.Di Filippo, M. et al. Fluid biomarkers in multiple sclerosis: From current to future applications. The Lancet Regional Health - Europe 44, 101009 (2024).