Cdc25C peptide is a Synthetic peptide. >97% purity and suitable for FuncS, HPLC.
K K K V S R S G L Y R S P S M P E N L N R P R
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application FuncS | Reactivity Reacts | Dilution info - | Notes - |
Application HPLC | Reactivity Reacts | Dilution info - | Notes - |
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Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle (PubMed:8119945). When phosphorylated, highly effective in activating G2 cells into prophase (PubMed:8119945). Directly dephosphorylates CDK1 and activates its kinase activity (PubMed:8119945).
M-phase inducer phosphatase 3, Dual specificity phosphatase Cdc25C, CDC25C
Cdc25C peptide is a Synthetic peptide. >97% purity and suitable for FuncS, HPLC.
Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle (PubMed:8119945). When phosphorylated, highly effective in activating G2 cells into prophase (PubMed:8119945). Directly dephosphorylates CDK1 and activates its kinase activity (PubMed:8119945).
Belongs to the MPI phosphatase family.
Phosphorylated by CHEK1 and MAPK14 at Ser-216. This phosphorylation creates a binding site for 14-3-3 protein and inhibits the phosphatase. Phosphorylated by PLK4. Phosphorylated by PLK1, leading to activate the phosphatase activity. Phosphorylation by PLK3 at Ser-191 promotes nuclear translocation. Ser-198 is a minor phosphorylation site. Was initially reported to be phosphorylated by PLK3 at Ser-216 (PubMed:10557092). However, such phosphorylation by PLK3 was not confirmed by other groups. Phosphorylation at Thr-48, Thr-67, Ser-122, Thr-130, Ser-168 and Ser-214 occurs at G2 and G2-M transition and is probably catalyzed by CDK1. Ser-168 phosphorylation levels are lower than those at the other 5 CDK1 sites. Phosphorylation by CDK1 leads to increased activity.
ab204854 (Cdc25C peptide) can be utilized as a substrate for the following active protein kinases:
Recombinant human BRSK2 protein ab139629 (Active human BRSK2 full length protein)
Recombinant human Chk1 protein ab60762 (Active human Chk1 full length protein)
Recombinant human Chk1 protein ab69918 (Active human Chk1 full length protein)
Recombinant human MARK2 protein ab119135 (Active human MARK2 full length protein)
Recombinant human Mark3 protein ab60012 (Active human Mark3 full length protein)
Recombinant human MARK4 protein ab105211 (Active human MARK4 full length protein)
ab179497 (Active human Serine/threonine-protein kinase NIM1 full length protein)
Recombinant human ARK5 protein ab125626 (Active human ARK5 full length protein)
Recombinant human NUAK2 protein ab105209 (Active human NUAK2 full length protein)
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