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CREB peptide is a Synthetic peptide. >96% purity and suitable for FuncS, HPLC.
Alternative names=Cyclic AMP-responsive element-binding protein 1, CREB-1, cAMP-responsive element-binding protein 1, CREB1
- Purity
>96% HPLC
- Tags
Tag free
- Applications
FuncS, HPLC
- Biologically active
No
- Sequence
K R R E I L S R R P S Y R
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application FuncS | Reactivity Reacts | Dilution info - | Notes - |
Application HPLC | Reactivity Reacts | Dilution info - | Notes - |
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CREB peptide is a Synthetic peptide. >96% purity and suitable for FuncS, HPLC.
Alternative names=Cyclic AMP-responsive element-binding protein 1, CREB-1, cAMP-responsive element-binding protein 1, CREB1
Key facts
- Purity
>96% HPLC
- Tags
Tag free
- Applications
FuncS, HPLC
- Biologically active
No
- Amino acids
109 to 121
- Sequence
K R R E I L S R R P S Y R
- Accession
- P16220-2
- Animal free
No
- Nature
Synthetic
- Species
Human
- Reconstitution
Dilute peptide in 20mM Tris-HCl, pH 7.5 solution to a final concentration of 1 mg/ml. For optimal storage, aliquot diluted product into smaller quantities and store at recommended temperature.
- Concentration
Specifications
- Form
Lyophilized
General info
- Function
Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.
- Sequence similarities
Belongs to the bZIP family.
- Post-translational modifications
Stimulated by phosphorylation. Phosphorylation of both Ser-119 and Ser-128 in the SCN regulates the activity of CREB and participates in circadian rhythm generation. Phosphorylation of Ser-119 allows CREBBP binding. In liver, phosphorylation is induced by fasting or glucagon in a circadian fashion (By similarity). CREBL2 positively regulates phosphorylation at Ser-119 thereby stimulating CREB1 transcriptional activity (By similarity). Phosphorylated upon calcium influx by CaMK4 and CaMK2 on Ser-119. CaMK4 is much more potent than CaMK2 in activating CREB. Phosphorylated by CaMK2 on Ser-128. Phosphorylation of Ser-128 blocks CREB-mediated transcription even when Ser-119 is phosphorylated. Phosphorylated by CaMK1 (By similarity). Phosphorylation of Ser-257 by HIPK2 in response to genotoxic stress promotes CREB1 activity, facilitating the recruitment of the coactivator CBP. Phosphorylated at Ser-119 by RPS6KA3, RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli. Phosphorylated by TSSK4 on Ser-119 (PubMed:15964553).
- Subcellular localisation
Nucleus
Storage
- Shipped at conditions
Blue Ice
- Appropriate long-term storage conditions
-20°C
- Storage information
Avoid freeze / thaw cycle
Notes
ab204856 (CREB peptide) can be utilized as a substrate for the following active protein kinases:
ab190396 (Active human KSR1 protein fragment)
ab185259 (Active human KSR2 protein fragment)
ab56268 (Active human cAMP Protein Kinase Catalytic subunit full length protein)
ab60837 (Active human PKA beta (catalytic subunit) full length protein)
ab60838 (Active human PKA gamma (catalytic subunit) full length protein)
ab60839 (Active X. laevis PKC alpha full length protein)
ab55672 (Active human PKC alpha full length protein)
ab60841 (Active human PKC beta 2 full length protein)
ab60844 (Active human PKC delta full length protein)
ab60850 (Active human PKC iota full length protein)
ab89860 (Active human PKN2 full length protein)
ab60873 (Active human PKC mu full length protein)
ab60874 (Active human PKC nu full length protein)
ab60848 (Active human PKC zeta full length protein)
ab60875 (Active human Protein Kinase D2 full length protein)
ab139624 (Active human STK19 full length protein)
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