CREB peptide is a Synthetic peptide. >96% purity and suitable for FuncS, HPLC.
K R R E I L S R R P S Y R
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application FuncS | Reactivity Reacts | Dilution info - | Notes - |
Application HPLC | Reactivity Reacts | Dilution info - | Notes - |
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Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters (By similarity). Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation (PubMed:14536081). Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells (By similarity). Regulates the expression of apoptotic and inflammatory response factors in cardiomyocytes in response to ERFE-mediated activation of AKT signaling (By similarity).
Cyclic AMP-responsive element-binding protein 1, CREB-1, cAMP-responsive element-binding protein 1, CREB1
CREB peptide is a Synthetic peptide. >96% purity and suitable for FuncS, HPLC.
Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters (By similarity). Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation (PubMed:14536081). Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells (By similarity). Regulates the expression of apoptotic and inflammatory response factors in cardiomyocytes in response to ERFE-mediated activation of AKT signaling (By similarity).
Belongs to the bZIP family.
Stimulated by phosphorylation. Phosphorylation of both Ser-119 and Ser-128 in the SCN regulates the activity of CREB and participates in circadian rhythm generation. Phosphorylation of Ser-119 allows CREBBP binding. In liver, phosphorylation is induced by fasting or glucagon in a circadian fashion (By similarity). CREBL2 positively regulates phosphorylation at Ser-119 thereby stimulating CREB1 transcriptional activity (By similarity). Phosphorylated upon calcium influx by CaMK4 and CaMK2 on Ser-119. CaMK4 is much more potent than CaMK2 in activating CREB. Phosphorylated by CaMK2 on Ser-128. Phosphorylation of Ser-128 blocks CREB-mediated transcription even when Ser-119 is phosphorylated. Phosphorylated by CaMK1 (By similarity). Phosphorylation of Ser-257 by HIPK2 in response to genotoxic stress promotes CREB1 activity, facilitating the recruitment of the coactivator CBP. Phosphorylated at Ser-119 by RPS6KA3, RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli. Phosphorylated by TSSK4 on Ser-119 (PubMed:15964553).
ab204856 (CREB peptide) can be utilized as a substrate for the following active protein kinases:
Recombinant human KSR1 protein ab190396 (Active human KSR1 protein fragment)
Recombinant human KSR2 protein ab185259 (Active human KSR2 protein fragment)
Recombinant human cAMP Protein Kinase Catalytic subunit ab56268 (Active human cAMP Protein Kinase Catalytic subunit full length protein)
Recombinant human PKA beta (catalytic subunit) protein ab60837 (Active human PKA beta (catalytic subunit) full length protein)
Recombinant human PRKACG protein ab60838 (Active human PKA gamma (catalytic subunit) full length protein)
Recombinant X. laevis PKC alpha protein ab60839 (Active X. laevis PKC alpha full length protein)
Recombinant human PKC alpha protein (Active) ab55672 (Active human PKC alpha full length protein)
Recombinant human PKC beta 2 protein ab60841 (Active human PKC beta 2 full length protein)
Recombinant human PKC delta protein ab60844 (Active human PKC delta full length protein)
Recombinant human PKC iota protein ab60850 (Active human PKC iota full length protein)
Recombinant human PKN2 protein ab89860 (Active human PKN2 full length protein)
Recombinant human PKC mu/PKD protein ab60873 (Active human PKC mu full length protein)
Recombinant human PKC nu/PRKD3 protein ab60874 (Active human PKC nu full length protein)
Recombinant human PKC zeta protein ab60848 (Active human PKC zeta full length protein)
ab60875 (Active human Protein Kinase D2 full length protein)
Recombinant human STK19/G11 protein ab139624 (Active human STK19 full length protein)
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