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AB204856

CREB peptide

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CREB peptide is a Synthetic peptide. >96% and suitable for FuncS, HPLC.

View Alternative Names

Cyclic AMP-responsive element-binding protein 1, CREB-1, cAMP-responsive element-binding protein 1, CREB1

Key facts

Purity

>96% HPLC

Tags

Tag free

Applications

HPLC, FuncS

applications

Biologically active

No

Accession

P16220

Animal free

No

Carrier free

No

Species

Human

Reconstitution

reconstitute with 20 mM Tris-HCl, pH 7.5 at 1mg/mL

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "HPLC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

ab204856 (CREB peptide) can be utilized as a substrate for the following active protein kinases:

ab190396 (Active human KSR1 protein fragment)
ab185259 (Active human KSR2 protein fragment)
ab56268 (Active human cAMP Protein Kinase Catalytic subunit full length protein)
ab60837 (Active human PKA beta (catalytic subunit) full length protein)
ab60838 (Active human PKA gamma (catalytic subunit) full length protein)
ab60839 (Active X. laevis PKC alpha full length protein)
ab55672 (Active human PKC alpha full length protein)
ab60841 (Active human PKC beta 2 full length protein)
ab60844 (Active human PKC delta full length protein)
ab60850 (Active human PKC iota full length protein)
ab89860 (Active human PKN2 full length protein)
ab60873 (Active human PKC mu full length protein)
ab60874 (Active human PKC nu full length protein)
ab60848 (Active human PKC zeta full length protein)
ab60875 (Active human Protein Kinase D2 full length protein)
ab139624 (Active human STK19 full length protein)

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Sequence info

[{"sequence":"KRREILSRRPSYR","proteinLength":null,"predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":121,"aminoAcidStart":109,"nature":"Synthetic","expressionSystem":null,"accessionNumber":"P16220","tags":[]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
False
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Specifications

Form

Lyophilized

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General info

Function

Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters (By similarity). Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation (PubMed : 14536081). Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells (By similarity). Regulates the expression of apoptotic and inflammatory response factors in cardiomyocytes in response to ERFE-mediated activation of AKT signaling (By similarity).

Sequence similarities

Belongs to the bZIP family.

Post-translational modifications

Stimulated by phosphorylation. Phosphorylation of both Ser-119 and Ser-128 in the SCN regulates the activity of CREB and participates in circadian rhythm generation. Phosphorylation of Ser-119 allows CREBBP binding. In liver, phosphorylation is induced by fasting or glucagon in a circadian fashion (By similarity). CREBL2 positively regulates phosphorylation at Ser-119 thereby stimulating CREB1 transcriptional activity (By similarity). Phosphorylated upon calcium influx by CaMK4 and CaMK2 on Ser-119. CaMK4 is much more potent than CaMK2 in activating CREB. Phosphorylated by CaMK2 on Ser-128. Phosphorylation of Ser-128 blocks CREB-mediated transcription even when Ser-119 is phosphorylated. Phosphorylated by CaMK1 (By similarity). Phosphorylation of Ser-257 by HIPK2 in response to genotoxic stress promotes CREB1 activity, facilitating the recruitment of the coactivator CBP. Phosphorylated at Ser-119 by RPS6KA3, RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli. Phosphorylated by TSSK4 on Ser-119 (PubMed:15964553).. Sumoylated with SUMO1. Sumoylation on Lys-290, but not on Lys-271, is required for nuclear localization of this protein. Sumoylation is enhanced under hypoxia, promoting nuclear localization and stabilization.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters (By similarity). Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation (PubMed : 14536081). Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells (By similarity). Regulates the expression of apoptotic and inflammatory response factors in cardiomyocytes in response to ERFE-mediated activation of AKT signaling (By similarity).
See full target information CREB1
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Primary Antibodies

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Assay Kits

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Assay Kits

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AP1 (c-Fos/FosB/Fra1/c-Jun/JunD) Transcription Factor Assay Kit (Colorimetric)

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