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AB204860

Glycogen synthase 1/GYS1 peptide

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Glycogen synthase 1/GYS1 peptide is a Synthetic peptide. >95% and suitable for FuncS, HPLC.

View Alternative Names

GYS, GYS1, Glycogen synthase 1

Key facts

Purity

>95% HPLC

Tags

Tag free

Applications

FuncS, HPLC

applications

Biologically active

No

Accession

P13807

Animal free

No

Carrier free

No

Species

Human

Reconstitution

reconstitute with 20 mM Tris-HCl, pH 7.5 at 1mg/mL

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Complementary Products

Proteins & Peptides

AB158615

Recombinant Human Glycogen synthase 1/GYS1 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human Glycogen synthase 1/GYS1 protein (GST tag N-Terminus) (AB158615)

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Primary Antibodies

AB40810

Anti-Glycogen synthase 1/GYS1 antibody [EP817Y]

20ul selling size|RabMAb|Recombinant|KO Validated

Flow Cytometry (Intracellular) - Anti-Glycogen synthase 1/GYS1 antibody [EP817Y] (AB40810)

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Proteins & Peptides

AB70538

Recombinant Human IRS1 protein

SDS-PAGE - Recombinant Human IRS1 protein (AB70538)

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Proteins & Peptides

AB271531

Recombinant Mouse Glycogenin 1 + GYS1 protein (Strep tag C-Terminus, His tag N-Terminus)

SDS-PAGE - Recombinant Mouse Glycogenin 1 + GYS1 protein (Strep tag C-Terminus, His tag N-Terminus) (AB271531)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "HPLC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

ab204860 (Glycogen synthase 1/GYS1 peptide) can be utilized as a substrate for the following active protein kinases:

ab60863 (Active human GSK3 beta full length protein)
ab63193 (Active human GSK3 beta full length protein)

This product was previously labelled as Glycogen synthase 1

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Sequence info

[{"linker":null,"sequence":"YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE","proteinLength":null,"predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":661,"aminoAcidStart":636,"nature":"Synthetic","expressionSystem":null,"accessionNumber":"P13807","tags":[]}]
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Properties and storage information

Form
Lyophilized
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
False
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General info

Function

Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.

Sequence similarities

Belongs to the glycosyltransferase 3 family.

Post-translational modifications

Phosphorylation at Ser-8 by AMPK inactivates the enzyme activity. Primed phosphorylation at Ser-657 (site 5) by CSNK2A1 and CSNK2A2 is required for inhibitory phosphorylation at Ser-641 (site 3a), Ser-645 (site 3b), Ser-649 (site 3c) and Ser-653 (site 4) by GSK3A an GSK3B (By similarity). Phosphorylated at Ser-641 by DYRK2, leading to inactivation (By similarity). Phosphorylated at Ser-641 by PASK, leading to inactivation; phosphorylation by PASK is inhibited by glycogen. Dephosphorylation at Ser-641 and Ser-645 by PP1 activates the enzyme (PubMed:35835870).

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Product protocols

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Target data

Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.
See full target information GYS1
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Product promise

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