JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB41752

Human EAAT2 peptide

4

(1 Review)

|

(1 Publication)

Human EAAT2 peptide is a Synthetic blocking peptide. >90% and suitable for BL.

View Alternative Names

EAAT2, GLT1, SLC1A2, Excitatory amino acid transporter 2, Glutamate/aspartate transporter II, Sodium-dependent glutamate/aspartate transporter 2, Solute carrier family 1 member 2

Key facts

Purity

>90%

Tags

Tag free

Applications

BL

applications

Biologically active

No

Accession

P43004

Animal free

No

Carrier free

No

Species

Human

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "BL": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"1 µg/mL", "notes":"<p></p>" } } }
style
left-column

Product details

Reconstitution instructions:

- First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.

- If the peptide doesn't dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.

- Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.

- Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.

- Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

style
left-column

Sequence info

[{"sequence":null,"proteinLength":null,"predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":0,"aminoAcidStart":0,"nature":"Synthetic","expressionSystem":null,"accessionNumber":"P43004","tags":[]}]
style
left-column

Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column
style
left-column

Specifications

Form

Lyophilized

style
left-column

General info

Function

Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed : 14506254, PubMed : 15265858, PubMed : 26690923, PubMed : 7521911). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed : 14506254). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed : 14506254). Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate (By similarity).

Sequence similarities

Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A2 subfamily.

Post-translational modifications

Glycosylated.. Palmitoylation at Cys-38 is not required for correct subcellular localization, but is important for glutamate uptake activity.

style
left-column

Product protocols

style
left-column

Target data

Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed : 14506254, PubMed : 15265858, PubMed : 26690923, PubMed : 7521911). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed : 14506254). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed : 14506254). Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate (By similarity).
See full target information SLC1A2
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

American journal of physiology. Regulatory, integr 303:R291-300 PubMed22696576

2012

Altered astrocyte glutamate transporter regulation of hypothalamic neurosecretory neurons in heart failure rats.

Applications

Unspecified application

Species

Unspecified reactive species

Evgeniy S Potapenko,Vinicia C Biancardi,Yiqiang Zhou,Javier E Stern
View all publications
style
left-column
style
left-column
style
right-column

Complementary Products

Primary Antibodies

AB181036

Anti-EAAT1 antibody [EPR12686]

RabMAb|Recombinant

Western blot - Anti-EAAT1 antibody [EPR12686] (AB181036)

  • 5
  • 3
Primary Antibodies

AB203130

Anti-EAAT2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EAAT2 antibody (AB203130)

  • 0
  • 0
Biochemicals

AB120272

Riluzole (PK 26124), GABA uptake inhibitor

Chemical Structure - Riluzole (PK 26124), GABA uptake inhibitor (AB120272)

  • 0
  • 0
Primary Antibodies

AB87117

Anti-ALDH1L1 antibody - Astrocyte Marker

Lab Essentials

Western blot - Anti-ALDH1L1 antibody - Astrocyte Marker (AB87117)

  • 4
  • 11

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com