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AB31875

Human Hepcidin-25 peptide

4

(1 Review)

|

(5 Publications)

Human Hepcidin-25 peptide is a Synthetic blocking peptide. >70% and suitable for ELISA, BL.

View Alternative Names

HEPC, LEAP1, UNQ487/PRO1003, HAMP, Hepcidin, Liver-expressed antimicrobial peptide 1, Putative liver tumor regressor, LEAP-1, PLTR

Key facts

Purity

>70% HPLC

Tags

Tag free

Applications

ELISA, BL

applications

Biologically active

No

Accession

P81172

Animal free

No

Carrier free

No

Species

Human

Reconstitution

Reconstitute in 10% 0.5M acetic acid, 90% TK buffer

Storage buffer

Constituents: 0.87% Sodium chloride, 0.714% HEPES, 0.3% Acetic acid, 0.0584% EDTA, 0.001% Sorbitan monolaurate, ethoxylated

storage-buffer

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Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB30760

Anti-Hepcidin-25 antibody

BOND RX™ Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Hepcidin-25 antibody (AB30760)

  • 4
  • 9
Primary Antibodies

AB69090

Anti-Ferritin Light Chain antibody

Western blot - Anti-Ferritin Light Chain antibody (AB69090)

  • 5
  • 34
Primary Antibodies

AB75973

Anti-Ferritin heavy chain antibody [EPR3004Y]

RabMAb|Recombinant|KO Validated

Western blot - Anti-Ferritin heavy chain antibody [EPR3004Y] (AB75973)

  • 4
  • 7
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "BL": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

Storage buffer: 10% 0.5M acetic acid, 90% TK buffer. pH 3.6

Solutions of ab31875, diluted 10 times, in TBST (80%) and PBS (10%) have a pH of 5.1

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Sequence info

[{"sequence":null,"proteinLength":null,"predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":0,"aminoAcidStart":0,"nature":"Synthetic","expressionSystem":null,"accessionNumber":"P81172","tags":[]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Specifications

Form

Lyophilized

Additional notes

70 - 90% by HPLC

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General info

Function

Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma (PubMed : 22682227, PubMed : 29237594, PubMed : 32814342). Controls the major flows of iron into plasma : absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes (PubMed : 22306005).. Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa (PubMed : 11034317, PubMed : 11113131).

Sequence similarities

Belongs to the hepcidin family.

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Product protocols

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Target data

Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma (PubMed : 22682227, PubMed : 29237594, PubMed : 32814342). Controls the major flows of iron into plasma : absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes (PubMed : 22306005).. Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa (PubMed : 11034317, PubMed : 11113131).
See full target information HAMP
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Journal of cellular and molecular medicine 28:e18543 PubMed39054575

2024

Cardiomyocyte-specific overexpression of FPN1 diminishes cardiac hypertrophy induced by chronic intermittent hypoxia.

Applications

Unspecified application

Species

Unspecified reactive species

Ji-Xian Song,Shan Xu,Qi Chen,Yujing Gou,Chen-Bing Zhao,Cui-Ling Jia,Han Liu,Zhi Zhang,Bo-Liang Li,Yuhui Gao,Yashuo Zhao,En-Sheng Ji

Aging 13:26063-26094 PubMed34954691

2021

Tertiary lymphoid structure stratifies glioma into three distinct tumor subtypes.

Applications

Unspecified application

Species

Unspecified reactive species

Xingwang Zhou,Wenyan Li,Jie Yang,Xiaolan Qi,Yimin Chen,Hua Yang,Liangzhao Chu

Biochimica et biophysica acta. Molecular and cell biology of lipids 1865:158531 PubMed31666189

2019

Macrophage iron retention aggravates atherosclerosis: Evidence for the role of autocrine formation of hepcidin in plaque macrophages.

Applications

Unspecified application

Species

Unspecified reactive species

Lin Xiao,Gang Luo,Xiaoping Guo,Chunjie Jiang,Hongmei Zeng,Feng Zhou,Yanyan Li,Jiasheng Yu,Ping Yao

Circulation 134:1025-1038 PubMed27576776

2016

Toll-Like Receptor 4/MyD88-Mediated Signaling of Hepcidin Expression Causing Brain Iron Accumulation, Oxidative Injury, and Cognitive Impairment After Intracerebral Hemorrhage.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao-Yi Xiong,Liang Liu,Fa-Xiang Wang,Yuan-Rui Yang,Jun-Wei Hao,Peng-Fei Wang,Qi Zhong,Kai Zhou,Ao Xiong,Wen-Yao Zhu,Ting Zhao,Zhao-You Meng,Yan-Chun Wang,Qiu-Wen Gong,Mao-Fan Liao,Jian Wang,Qing-Wu Yang

PloS one 9:e89003 PubMed24533165

2014

Glial cell ceruloplasmin and hepcidin differentially regulate iron efflux from brain microvascular endothelial cells.

Applications

Unspecified application

Species

Unspecified reactive species

Ryan C McCarthy,Daniel J Kosman
View all publications
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Product promise

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