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AB271195

Anti-Huntingtin antibody [EPR5526] blocking peptide

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Anti-Huntingtin antibody [EPR5526] blocking peptide is a Synthetic blocking peptide. >90% and suitable for BL.

View Alternative Names

HD, IT15, HTT, Huntingtin, Huntington disease protein, HD protein

Key facts

Purity

>90% HPLC

Tags

Tag free

Applications

BL

applications

Biologically active

No

Accession

P42858

Animal free

No

Carrier free

No

Species

Human

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "BL": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":null,"proteinLength":null,"predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":0,"aminoAcidStart":0,"nature":"Synthetic","expressionSystem":null,"accessionNumber":"P42858","tags":[]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
-20°C
False
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Specifications

Form

Lyophilized

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General info

Function

Huntingtin. May play a role in microtubule-mediated transport or vesicle function.. Huntingtin, myristoylated N-terminal fragment. Promotes the formation of autophagic vesicles.

Sequence similarities

Belongs to the huntingtin family.

Post-translational modifications

Huntingtin. Cleaved by caspases downstream of the polyglutamine stretch (PubMed:10770929, PubMed:29802276, PubMed:8696339, PubMed:9535906). The resulting N-terminal fragments are cytotoxic and provokes apoptosis (PubMed:10770929).. Huntingtin. Forms with expanded polyglutamine expansion are specifically ubiquitinated by SYVN1, which promotes their proteasomal degradation.. Huntingtin. Phosphorylation at Ser-1179 and Ser-1199 by CDK5 in response to DNA damage in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity.. Huntingtin, myristoylated N-terminal fragment. Myristoylated at Gly-551, following proteolytic cleavage at Asp-550.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Huntingtin. May play a role in microtubule-mediated transport or vesicle function.. Huntingtin, myristoylated N-terminal fragment. Promotes the formation of autophagic vesicles.
See full target information HTT
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