Mouse Myelin Basic Protein peptide

Specifications

Form

Liquid

General info

Function

The classic group of MBP isoforms (isoform 4-isoform 13) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined to optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function.

Sequence similarities

Belongs to the myelin basic protein family.

Post-translational modifications

As in other animals, several charge isomers may be produced as a result of optional post-translational modifications, such as phosphorylation of serine or threonine residues, deamidation of glutamine or asparagine residues, citrullination and methylation of arginine residues.. Methylated on arginine residues; decreases with the age of the animal, making MBP more cationic.. Phosphorylated by TAOK2, VRK2, MAPK11, MAPK12, MAPK14 and MINK1.. Proteolytically cleaved in B cell lysosomes by cathepsin CTSG which degrades the major immunogenic MBP epitope and prevents the activation of MBP-specific autoreactive T cells.

Subcellular localisation

Nucleus