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AB179799

NADPH oxidase 4 peptide

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(0 Publication)

NADPH oxidase 4 peptide is a Synthetic blocking peptide.

View Alternative Names

RENOX, NOX4, NADPH oxidase 4, Kidney oxidase-1, Kidney superoxide-producing NADPH oxidase, Renal NAD(P)H-oxidase, KOX-1

Key facts

Purity

Whole antiserum

Tags

Tag free

Applications

BL

applications

Biologically active

No

Accession

Q9NPH5

Animal free

No

Carrier free

No

Species

Human

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Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

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Primary Antibodies

AB131088

Anti-NOX1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NOX1 antibody (AB131088)

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  • 1
Proteins & Peptides

AB289740

Recombinant Human NADPH oxidase 4 protein

SDS-PAGE - Recombinant Human NADPH oxidase 4 protein (AB289740)

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Primary Antibodies

AB310337

Anti-NOX2/gp91phox antibody [EPR28415-13]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NOX2/gp91phox antibody [EPR28415-13] (AB310337)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "BL": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

- First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
- If the peptide doesn't dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
- Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
- Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
- Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.
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Sequence info

[{"sequence":null,"proteinLength":null,"predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":0,"aminoAcidStart":0,"nature":"Synthetic","expressionSystem":null,"accessionNumber":"Q9NPH5","tags":[]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
Up to 12 months
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Specifications

Form

Liquid

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General info

Function

NADPH oxidase that catalyzes predominantly the reduction of oxygen to H2O2 (PubMed : 14966267, PubMed : 15356101, PubMed : 15927447, PubMed : 21343298, PubMed : 25062272). Can also catalyze to a smaller extent, the reduction of oxygen to superoxide (PubMed : 10869423, PubMed : 11032835, PubMed : 15155719, PubMed : 15572675, PubMed : 15927447, PubMed : 16019190, PubMed : 16179589, PubMed : 16230378, PubMed : 16324151, PubMed : 25062272). May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity (PubMed : 16019190). May regulate insulin signaling cascade (PubMed : 14966267). May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB (PubMed : 15356101, PubMed : 15572675). May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation (PubMed : 16324151). Promotes ferroptosis, reactive oxygen species production and reduced glutathione (GSH) levels by activating NLRP3 inflammasome activation and cytokine release (PubMed : 39909992).. Isoform 4. NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor (PubMed : 15721269, PubMed : 23393389). Involved in redox signaling in vascular cells (PubMed : 23393389). Modulates the nuclear activation of ERK1/2 and the ELK1 transcription factor, and is capable of inducing nuclear DNA damage (PubMed : 23393389).. Isoform 3. Lacks superoxide-generating NADPH oxidase activity.

Post-translational modifications

Deubiquitinated by USP19.. Isoform 4. N-glycosylated and glycosylation is required for its proper function.. Isoform 3. N-glycosylated.

Subcellular localisation

Nucleus

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Product protocols

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Target data

NADPH oxidase that catalyzes predominantly the reduction of oxygen to H2O2 (PubMed : 14966267, PubMed : 15356101, PubMed : 15927447, PubMed : 21343298, PubMed : 25062272). Can also catalyze to a smaller extent, the reduction of oxygen to superoxide (PubMed : 10869423, PubMed : 11032835, PubMed : 15155719, PubMed : 15572675, PubMed : 15927447, PubMed : 16019190, PubMed : 16179589, PubMed : 16230378, PubMed : 16324151, PubMed : 25062272). May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity (PubMed : 16019190). May regulate insulin signaling cascade (PubMed : 14966267). May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB (PubMed : 15356101, PubMed : 15572675). May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation (PubMed : 16324151). Promotes ferroptosis, reactive oxygen species production and reduced glutathione (GSH) levels by activating NLRP3 inflammasome activation and cytokine release (PubMed : 39909992).. Isoform 4. NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor (PubMed : 15721269, PubMed : 23393389). Involved in redox signaling in vascular cells (PubMed : 23393389). Modulates the nuclear activation of ERK1/2 and the ELK1 transcription factor, and is capable of inducing nuclear DNA damage (PubMed : 23393389).. Isoform 3. Lacks superoxide-generating NADPH oxidase activity.
See full target information NOX4
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Product promise

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