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Native Bovine Collagen protein (FITC) is a Cow Full Length protein and expressed in Native.

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Key facts

Expression system

Native

Tags

Tag free

Biologically active

No

Conjugation

FITC

Target data

Function

Type I collagen is a member of group I collagen (fibrillar forming collagen).

Alternative names

Recommended products

Native Bovine Collagen protein (FITC) is a Cow Full Length protein and expressed in Native.

Key facts

Expression system

Native

Conjugation

FITC

Excitation/Emission

Ex: 495nm, Em: 519nm

Accession
P02453-1
Animal free

No

Carrier free

Yes

Species

Cow

Reconstitution

Reconstitute in water

Concentration
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Storage buffer

Constituents: 100% Tris buffered saline

Sequence info

Amino acid sequence

Accession

P02453

Protein length

Full Length

Nature

Native

Specifications

Form

Lyophilized

General info

Function

Type I collagen is a member of group I collagen (fibrillar forming collagen).

Sequence similarities

Belongs to the fibrillar collagen family.

Post-translational modifications

Contains mostly 4-hydroxyproline. Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

Ambient

Appropriate long-term storage conditions

Ambient

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Collagen type I also called collagen I is a structural protein expressed mainly in connective tissues such as skin tendon bone and ligaments. It serves as an important component in providing mechanical strength and integrity to these tissues. Collagen I is a fibrillar collagen known for its triple-helix structure composed of two alpha-1 chains and one alpha-2 chain and has a molecular mass of approximately 300 kDa. Researchers often employ collagen western blot and collagen ELISA techniques for its detection. Collagen suppliers offer various collagen antibodies used in these assays to study its distribution and function.

Biological function summary

Collagen type I plays a central role in maintaining the extracellular matrix and supporting cellular environments. It interacts with other matrix proteins and cells forming complexes that help in tissue development and repair. Type I collagen is especially important in bone matrix working alongside minerals like hydroxyapatite to provide rigidity and support. Anti-collagen antibodies aid in studying its biological functions and interactions which are critical to understanding tissue dynamics.

Pathways

Collagen type I interacts with multiple signaling cascades involved in tissue remodeling and repair. It is a significant player in the TGF-β pathway which regulates fibrosis and wound healing processes. In these pathways proteins such as fibronectin and integrins work in concert with collagen type I to orchestrate cellular responses to damage. Researchers often examine its role in these pathways to uncover therapeutic possibilities for disease interventions.

Associated diseases and disorders

Collagen type I has strong connections to conditions like osteogenesis imperfecta and fibrosis. Mutations or irregularities in collagen I production can lead to osteogenesis imperfecta a genetic disorder characterized by brittle bones. In fibrosis excessive collagen deposition disrupts normal tissue architecture contributing to organ dysfunction. In both conditions type I collagen interacts with other proteins like matrix metalloproteinases which modulate its breakdown and remodeling highlighting its importance in disease pathology.

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