Native human C1q protein (Active) is a Human Full Length Complement Component 1q (C1q) protein with >98% purity and suitable for SDS-PAGE and Functional studies. The predicted molecular weight of ab282858 native protein is 410 kDa.
- Save time and ensure accurate results - use the native C1q protein as a control
- Optimal bioactivity and stability
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application FuncS | Reactivity Reacts | Dilution info - | Notes - |
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
Complement C1q subcomponent subunit A, C1QA
Native human C1q protein (Active) is a Human Full Length Complement Component 1q (C1q) protein with >98% purity and suitable for SDS-PAGE and Functional studies. The predicted molecular weight of ab282858 native protein is 410 kDa.
- Save time and ensure accurate results - use the native C1q protein as a control
- Optimal bioactivity and stability
One unit is the amount of functional C1q needed to lyse 50% of 3 x 107 antibody-sensitized sheep erythrocytes.
pH: 7.2
Constituents: 1.75% Sodium chloride, 0.2% HEPES
Purified from human plasma.
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
O-linked glycans are assumed to be the Glc-Gal disaccharides typically found as secondary modifications of hydroxylated lysines in collagen-like domains.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Ensure the validity of your result using our Native human C1q protein ab282858 as a control. ab282858 can be used as a positive control in SDS-PAGE.
Check out our Electrophoresis guide for SDS-PAGE here
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