Native Human Collagen VI protein is a Human Full Length protein, expressed in Native, with >95% purity and suitable for IP, ELISA, IHC-P, WB, SDS-PAGE.
>95%
Native
Tag free
IP, ELISA, IHC-P, WB, SDS-PAGE
No
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application IP | Reactivity Reacts | Dilution info - | Notes - |
Application ELISA | Reactivity Reacts | Dilution info 1/10000 | Notes - |
Application IHC-P | Reactivity Reacts | Dilution info 1/100 - 1/500 | Notes - |
Application WB | Reactivity Reacts | Dilution info 1/1000 | Notes Not recommended for use under denaturing conditions. |
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Select an associated product type
Collagen alpha-1(VI) chain, COL6A1
Native Human Collagen VI protein is a Human Full Length protein, expressed in Native, with >95% purity and suitable for IP, ELISA, IHC-P, WB, SDS-PAGE.
>95%
Native
Tag free
IP, ELISA, IHC-P, WB, SDS-PAGE
No
No
Human
Preservative: 0.01% Sodium azide
Constituents: 3% Acetic acid
Liquid
This product has been prepared from human placenta and is chromatographically and immunologically pure.
Collagen VI acts as a cell-binding protein.
Belongs to the type VI collagen family.
Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
Blue Ice
+4°C
+4°C
Diluted stock solutions should be used immediately and not be frozen, Store undiluted
This product is free from other collagens, human serum proteins and non-collagen extracellular matrix proteins. This product reacts with anti-Collagen Type VI. Reaction with anti-Collagen I, II, III, IV or V is negligible (typically less than 1% cross reactivity was detected by ELISA).
This supplementary information is collated from multiple sources and compiled automatically.
Collagen VI also known as Collagen 6 is a type of collagen that plays an important role in the extracellular matrix. It consists of three different chains: α1(VI) α2(VI) and α3(VI) with a combined mass of approximately 140 kDa. This collagen type strongly associates with several tissues notably in skeletal muscle skin and the walls of blood vessels. Scientists often study collagen VI with specific collagen antibodies to understand its unique structural properties and its end which binds to other matrix components.
Collagen VI contributes to structural integrity and cellular scaffolding within tissues. This protein is integral to the formation of microfibrillar networks part of a larger complex that connects the extracellular matrix to cells and other matrix components. Its protective role helps cells resist mechanical stress and the network provided by collagen VI powder stabilizes the tissue architecture. Additionally low endotoxin collagen is often preferable in research to minimize inflammatory responses during experimentation providing more accurate results.
Collagen VI participates in extracellular matrix organization and mechanotransduction pathways. It functions alongside other proteins like collagen I and IV. In particular collagen VI interacts with cell surface receptors which influences cellular communication and signaling pathways. This interaction plays a role in transmitting mechanical signals that affect cellular behavior and function proving important for tissue maintenance and repair processes.
Mutations or malfunctions involving collagen VI can lead to significant clinical outcomes. It is prominently linked with disorders such as Ullrich congenital muscular dystrophy and Bethlem myopathy both affecting muscle and connective tissue. These conditions often involve disruptions in the assembly or function of the collagen VI network. Additionally related proteins like collagen I and integrin proteins can influence the progression and severity of these disorders illustrating the interconnected nature of these extracellular elements.
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