Native Human IgA1 protein is a Human Full Length IgA1 protein with >95% purity and suitable for SDS-PAGE. The predicted molecular weight of ab91020 native protein is 160 kDa.
- Save time and ensure accurate results- use our native IgA1 protein as an isotype control
- No cross-reaction from other immunoglobulin isotypes
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Publications
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- Oxidative medicine and cellular longevity 2022:17407702022Mesangial Cell-Derived Exosomal miR-4455 Induces Podocyte Injury in IgA Nephropathy by Targeting ULK2.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMengjie Yu,Xiaogang Shen,Wenfang He,Danna Zheng,Qiang He,Juan JinPubMed 36388165
- Frontiers in pharmacology 13:8890082022Liuwei Dihuang Pills Inhibit Podocyte Injury and Alleviate IgA Nephropathy by Directly Altering Mesangial Cell-Derived Exosome Function and Secretion.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXiaodong Zhu,Xiaogang Shen,Bo Lin,Jiaxi Fang,Juan Jin,Qiang HePubMed 35899112
- Frontiers in medicine 9:8813222022Identification of Hub Genes and Therapeutic Agents for IgA Nephropathy Through Bioinformatics Analysis and Experimental Validation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMing Xia,Di Liu,Haiyang Liu,Liang Peng,Danyi Yang,Chengyuan Tang,Guochun Chen,Yu Liu,Hong LiuPubMed 35836957
- Frontiers in medicine 8:7949622021Based on Network Pharmacology Tools to Investigate the Mechanism of Against IgA Nephropathy.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMing Xia,Di Liu,Haiyang Liu,Juanyong Zhao,Chengyuan Tang,Guochun Chen,Yu Liu,Hong LiuPubMed 34977095
- Frontiers in immunology 12:7121302021Maternal IgA2 Recognizes Similar Fractions of Colostrum and Fecal Neonatal Microbiota.Applications:Unspecified applicationReactive species:Unspecified reactive speciesErick Sánchez-Salguero,Karina Corona-Cervantes,Hector Armando Guzmán-Aquino,María Fernanda de la Borbolla-Cruz,Víctor Contreras-Vargas,Alberto Piña-Escobedo,Jaime García-Mena,Leopoldo Santos-ArgumedoPubMed 34804008
- JCI insight 5:2020TLR7 in B cells promotes renal inflammation and Gd-IgA1 synthesis in IgA nephropathy.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNuoyan Zheng et. al.PubMed 32699192
- Maternal health, neonatology and perinatology 5:92019Infectious episodes during pregnancy, at particular mucosal sites, increase specific IgA1 or IgA2 subtype levels in human colostrum.Applications:Unspecified applicationReactive species:Unspecified reactive speciesErick Sánchez-Salguero et. al.PubMed 31205733
Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Native
- Tags
- Tag free
- Applications
- SDS-PAGE
- Biologically active
- No
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915).
Alternative names
Immunoglobulin heavy constant alpha 1, Ig alpha-1 chain C region, Ig alpha-1 chain C region BUR, Ig alpha-1 chain C region TRO, IGHA1
Recommended products
Native Human IgA1 protein is a Human Full Length IgA1 protein with >95% purity and suitable for SDS-PAGE. The predicted molecular weight of ab91020 native protein is 160 kDa.
- Save time and ensure accurate results- use our native IgA1 protein as an isotype control
- No cross-reaction from other immunoglobulin isotypes
Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Native
- Tags
- Tag free
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- P01876-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 0.87% Sodium chloride, 0.0268% PBS
Sequence info
Amino acid sequence
- Accession
- P01876
- Protein length
- Full Length
- Predicted molecular weight
- 160 kDa
- Nature
- Native
Specifications
- Form
- Liquid
General info
- Function
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915).
- Post-translational modifications
Isoform 1
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
Notes
Protein Determination: Extinction Coefficient (E) 0.1% at 280nm, 1cm pathway = 1.32. Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.No reaction by IEP to IgA2 antiserum.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
IgA1 also known as Immunoglobulin A1 is an important component of the immune system. This protein mainly exists in mucous membranes where it plays an important role in immune function. IgA1 has a mass of approximately 160 kDa and is expressed in various tissues including the respiratory and gastrointestinal tracts. IgA1 is a subclass of immunoglobulin A (IgA) and is characterized by its heavy chain constant region which distinguishes it from other immunoglobulin subclasses.
- Biological function summary
IgA1 acts as a first line of defense in the immune system by binding to pathogens and neutralizing them. It exists as a monomer or forms a dimer with the help of the J chain which stabilizes its dimeric form. IgA1 also interacts with the polymeric immunoglobulin receptor (pIgR) for transportation across epithelial cells. This transport allows IgA1 to be present in secretory fluids such as saliva and breast milk providing an important protective function.
- Pathways
IgA1 interacts with several pathways involved in immune response and mucosal immunity. One critical pathway is the mucosal antibody response where IgA1 plays a role in preventing infection at mucosal surfaces. The IgA1 protein activates the alternative complement pathway by binding to complement protein C3 which enhances the removal of pathogens. Furthermore IgA1 is associated with the J chain and pIgR in the process of IgA transcytosis across epithelial barriers.
- Associated diseases and disorders
IgA1 has strong connections to IgA nephropathy and celiac disease. In IgA nephropathy IgA1 deposits in glomeruli leading to inflammation and kidney damage. The increased serum levels of IgA1 often with aberrant glycosylation contribute to disease development. In celiac disease IgA1 reacts with tissue transglutaminase causing an immune response that damages the small intestine's lining. In both disorders the interactions between IgA1 and other proteins such as tissue transglutaminase in celiac disease highlight its involvement in pathological processes.
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SDS-PAGE - Native Human IgA1 protein (ab91020)
SDS-PAGE: 4-12% Bis-Tris NuPAGE gel
1. 5 μg Human IgA1 (reduced /heated)
2. 10 μg Human IgA1 (reduced/ heated)
3. 20 μg Human IgA1 (reduced/ heated)
4. Molecular weight markers
5. 5 μg Human IgA1 (non-reduced/no heat)
6. 10 μg Human IgA1 (non-reduced/no heat)
7. 20 μg Human IgA1 (non-reduced/no heat)
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