Native Human IgG FC fragment protein is a Full Length protein, expressed in Native, with >95% purity and suitable for SDS-PAGE.
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- Experimental and therapeutic medicine 26:4392023HOXC13 promotes cell proliferation, metastasis and glycolysis in breast cancer by regulating DNMT3A.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHongrui Li,Pengcheng Gao,Haifeng Chen,Junjie Zhao,Xiangzhong Zhang,Ganggang Li,Liting Wang,Long QinPubMed 37614427
- Experimental and therapeutic medicine 24:5512022FOSL1 knockdown ameliorates DSS-induced inflammation and barrier damage in ulcerative colitis via MMP13 downregulation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLizhuan Ma,Xiujing Zhang,Chao Zhang,Bingxu Hou,Hongtao ZhaoPubMed 35978937
- Experimental and therapeutic medicine 22:13882021Upregulation of AQP2 mediated by transcription factor FOXO1 inhibits TGF-β-induced fibrosis in human urothelial cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYue Qiu,Zhaoquan Xing,Zhaoxin Guo,Zhaoxu LiuPubMed 34650636
- Cancers 13:2021A Conjugation Strategy to Modulate Antigen Binding and FcRn Interaction Leads to Improved Tumor Targeting and Radioimmunotherapy Efficacy with an Antibody Targeting Prostate-Specific Antigen.Applications:Unspecified applicationReactive species:Unspecified reactive speciesOskar Vilhelmsson Timmermand,Anders Örbom,Mohamed Altai,Wahed Zedan,Bo Holmqvist,Marcella Safi,Thuy A Tran,Sven-Erik Strand,Joanna StrandPubMed 34298682
- Bone 143:1156572020JAGGED1 stimulates cranial neural crest cell osteoblast commitment pathways and bone regeneration independent of canonical NOTCH signaling.Applications:Unspecified applicationReactive species:Unspecified reactive speciesArchana Kamalakar,Jay M McKinney,Daniel Salinas Duron,Angelica M Amanso,Samir A Ballestas,Hicham Drissi,Nick J Willett,Pallavi Bhattaram,Andrés J García,Levi B Wood,Steven L GoudyPubMed 32980561
- Clinical cancer research : an official journal of the American Association for Cancer Research 26:669-6782019EGFL7 Antagonizes NOTCH Signaling and Represents a Novel Therapeutic Target in Acute Myeloid Leukemia.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMarius Bill,Aparna Pathmanathan,Malith Karunasiri,Changxian Shen,Matthew H Burke,Parvathi Ranganathan,Dimitrios Papaioannou,Nina C Zitzer,Katiri Snyder,Allison LaRocco,Allison E Walker,Zachary J Brannan,Ansel P Nalin,Aharon G Freud,Mikhail M Dikov,Xiaoli Zhang,Clara D Bloomfield,Ramiro Garzon,Adrienne M DorrancePubMed 31672772
- Cell death & disease 10:7322019MAG induces apoptosis in cerebellar granule neurons through p75 demarcating granule layer/white matter boundary.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDiana Fernández-Suárez et. al.PubMed 31570696
- Frontiers in immunology 9:5672018The Role of AIRE in the Immunity Against in a Model of Human Macrophages.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJose Antonio Tavares de Albuquerque et. al.PubMed 29666621
- Open biology 7:2017T-type Ca2+ channels are required for enhanced sympathetic axon growth by TNFα reverse signalling.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLilian Kisiswa,Clara Erice,Laurent Ferron,Sean Wyatt,Catarina Osório,Annette C Dolphin,Alun M DaviesPubMed 28100666
- Proceedings of the National Academy of Sciences of 113:14698-147032016Epithelial self-healing is recapitulated by a 3D biomimetic E-cadherin junction.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDaniel J Cohen et. al.PubMed 27930308
Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Native
- Tags
- Tag free
- Applications
- SDS-PAGE
- Biologically active
- No
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes MW is 31kDa |
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Native Human IgG FC fragment protein is a Full Length protein, expressed in Native, with >95% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Native
- Tags
- Tag free
- Applications
- SDS-PAGE
- Biologically active
- No
- Animal free
- No
- Concentration
- Storage buffer
pH: 8
Preservative: 0.05% Sodium azide
Constituents: 1.16% Sodium chloride, 0.79% Tris HCl
Sequence info
Amino acid sequence
- Protein length
- Full Length
- Predicted molecular weight
- 50 kDa
- Nature
- Native
Specifications
- Form
- Liquid
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Protein Determination: Extinction Coefficient (E) 0.1% at 280nm =1.46.
IgG is cleaved using Papain to product the Fc fragment. The IgG fc fragment does not bind antigen; however, it does contain the classic antigenic determinants and biological activity with respect to cytotrophic reactions, binding of complement and catabolic rate control.
Shown to be non reactive for HbsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 and 2 by FDA approved tests.
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1 product image
SDS-PAGE - Native Human IgG FC fragment protein (ab90285)
4-12% Bis-Tris NuPAGE Gel analysis of ab90285.
Lanes 1-3 show 5, 10 and 15 μg, respectively; run under heated/reducing conditions.
Lanes 4-6 show 5, 10 and 15 μg, respectively; not heated/non-reducing conditions.
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