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Native human Plasminogen protein (Active) is a Human Full Length protein, in the 20 to 810 aa range, expressed in Native, with >95% purity and suitable for SDS-PAGE.
Alternative names=Plasminogen, PLG
- Purity
>95% SDS-PAGE
- Expression system
Native
- Tags
Tag free
- Applications
SDS-PAGE
- Biologically active
Yes
- Sequence
E P L D D Y V N T Q G A S L F S V T K K Q L G A G S I E E C A A K C E E D E E F T C R A F Q Y H S K E Q Q C V I M A E N R K S S I I I R M R D V V L F E K K V Y L S E C K T G N G K N Y R G T M S K T K N G I T C Q K W S S T S P H R P R F S P A T H P S E G L E E N Y C R N P D N D P Q G P W C Y T T D P E K R Y D Y C D I L E C E E E C M H C S G E N Y D G K I S K T M S G L E C Q A W D S Q S P H A H G Y I P S K F P N K N L K K N Y C R N P D R E L R P W C F T T D P N K R W E L C D I P R C T T P P P S S G P T Y Q C L K G T G E N Y R G N V A V T V S G H T C Q H W S A Q T P H T H N R T P E N F P C K N L D E N Y C R N P D G K R A P W C H T T N S Q V R W E Y C K I P S C D S S P V S T E Q L A P T A P P E L T P V V Q D C Y H G D G Q S Y R G T S S T T T T G K K C Q S W S S M T P H R H Q K T P E N Y P N A G L T M N Y C R N P D A D K G P W C F T T D P S V R W E Y C N L K K C S G T E A S V V A P P P V V L L P D V E T P S E E D C M F G N G K G Y R G K R A T T V T G T P C Q D W A A Q E P H R H S I F T P E T N P R A G L E K N Y C R N P D G D V G G P W C Y T T N P R K L Y D Y C D V P Q C A A P S F D C G K P Q V E P K K C P G R V V G G C V A H P H S W P W Q V S L R T R F G M H F C G G T L I S P E W V L T A A H C L E K S P R P S S Y K V I L G A H Q E V N L E P H V Q E I E V S R L F L E P T R K D I A L L K L S S P A V I T D K V I P A C L P S P N Y V V A D R T E C F I T G W G E T Q G T F G A G L L K E A Q L P V I E N K V C N R Y E F L N G R V Q S T E L C A G H L A G G T D S C Q G D S G G P L V C F E K D K Y I L Q G V T S W G L G C A R P N K P G V Y V R V S R F V T W I E G V M R N N
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Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
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Native human Plasminogen protein (Active) is a Human Full Length protein, in the 20 to 810 aa range, expressed in Native, with >95% purity and suitable for SDS-PAGE.
Alternative names=Plasminogen, PLG
Key facts
- Purity
>95% SDS-PAGE
- Expression system
Native
- Tags
Tag free
- Applications
SDS-PAGE
- Biologically active
Yes
- Biological activity
No plasmin activity detected with the chromogenic substrate S-2251.
>98% conversion to plasmin is observed upon activation with uPA.
- Predicted molecular weight
92 kDa
- Amino acids
20 to 810
- Sequence
E P L D D Y V N T Q G A S L F S V T K K Q L G A G S I E E C A A K C E E D E E F T C R A F Q Y H S K E Q Q C V I M A E N R K S S I I I R M R D V V L F E K K V Y L S E C K T G N G K N Y R G T M S K T K N G I T C Q K W S S T S P H R P R F S P A T H P S E G L E E N Y C R N P D N D P Q G P W C Y T T D P E K R Y D Y C D I L E C E E E C M H C S G E N Y D G K I S K T M S G L E C Q A W D S Q S P H A H G Y I P S K F P N K N L K K N Y C R N P D R E L R P W C F T T D P N K R W E L C D I P R C T T P P P S S G P T Y Q C L K G T G E N Y R G N V A V T V S G H T C Q H W S A Q T P H T H N R T P E N F P C K N L D E N Y C R N P D G K R A P W C H T T N S Q V R W E Y C K I P S C D S S P V S T E Q L A P T A P P E L T P V V Q D C Y H G D G Q S Y R G T S S T T T T G K K C Q S W S S M T P H R H Q K T P E N Y P N A G L T M N Y C R N P D A D K G P W C F T T D P S V R W E Y C N L K K C S G T E A S V V A P P P V V L L P D V E T P S E E D C M F G N G K G Y R G K R A T T V T G T P C Q D W A A Q E P H R H S I F T P E T N P R A G L E K N Y C R N P D G D V G G P W C Y T T N P R K L Y D Y C D V P Q C A A P S F D C G K P Q V E P K K C P G R V V G G C V A H P H S W P W Q V S L R T R F G M H F C G G T L I S P E W V L T A A H C L E K S P R P S S Y K V I L G A H Q E V N L E P H V Q E I E V S R L F L E P T R K D I A L L K L S S P A V I T D K V I P A C L P S P N Y V V A D R T E C F I T G W G E T Q G T F G A G L L K E A Q L P V I E N K V C N R Y E F L N G R V Q S T E L C A G H L A G G T D S C Q G D S G G P L V C F E K D K Y I L Q G V T S W G L G C A R P N K P G V Y V R V S R F V T W I E G V M R N N
- Accession
- P00747-1
- Protein length
Full Length
- Animal free
No
- Nature
Native
- Species
Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: 2.38% HEPES, 0.58% Sodium chloride
Specifications
- Form
Liquid
General info
- Function
Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.
- Sequence similarities
Belongs to the peptidase S1 family. Plasminogen subfamily.
- Post-translational modifications
N-linked glycan contains N-acetyllactosamine and sialic acid. O-linked glycans consist of Gal-GalNAc disaccharide modified with up to 2 sialic acid residues (microheterogeneity).
Storage
- Shipped at conditions
Dry Ice
- Appropriate long-term storage conditions
-80°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Notes
ab92924 is purified from Human plasma that is tested and found negative for all communicable diseases, including HIV1, HIV2, Hepatitis Surface antigen and HCV.
Solubility: > 2 mg/mL
Extinction coefficient: Epsilon0.1%= 1.69
Prepared from fresh human plasma by immobilized lysine chromatography.
Ultraviolet: Absorbance (280nm) = 16.56
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