Native Human Von Willebrand Factor protein is a Human Full Length protein with >95% purity and suitable for SDS-PAGE. The predicted molecular weight of ab88533 native protein is 260 kDa (monomer).
- Save time and ensure accurate results- use our Von Willebrand Factor (VWF) protein as a control.
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Publications
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- Frontiers in cellular and infection microbiology 11:6949572021Von Willebrand Factor Facilitates Intravascular Dissemination of Microsporidia .Applications:Unspecified applicationReactive species:Unspecified reactive speciesJialing Bao,Biying Mo,Guozhen An,Jian Luo,Mortimer Poncz,Guoqing Pan,Tian Li,Zeyang ZhouPubMed 34095003
- Journal of thrombosis and haemostasis : JTH 18:942-9542020Cleavage by MMP-13 renders VWF unable to bind to collagen but increases its platelet reactivity.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJoanna-Marie Howes,Vera Knäuper,Jean-Daniel Malcor,Richard W FarndalePubMed 31894636
- Nature chemical biology 16:423-4292020Chain alignment of collagen I deciphered using computationally designed heterotrimers.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAbhishek A Jalan,Douglas Sammon,Jeffrey D Hartgerink,Paul Brear,Katherine Stott,Samir W Hamaia,Emma J Hunter,Douglas R Walker,Birgit Leitinger,Richard W FarndalePubMed 31907373
Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Native
- Tags
- Tag free
- Applications
- SDS-PAGE
- Biologically active
- No
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
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Target data
Function
Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
Alternative names
F8VWF, VWF, von Willebrand factor, vWF
Recommended products
Native Human Von Willebrand Factor protein is a Human Full Length protein with >95% purity and suitable for SDS-PAGE. The predicted molecular weight of ab88533 native protein is 260 kDa (monomer).
- Save time and ensure accurate results- use our Von Willebrand Factor (VWF) protein as a control.
Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Native
- Tags
- Tag free
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- P04275-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 6.8
Constituents: 0.75% Glycine, 0.735% Sodium citrate, 0.58% Sodium chloride
Specifications
- Form
- Liquid
General info
- Function
Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
- Post-translational modifications
All cysteine residues are involved in intrachain or interchain disulfide bonds.
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
The Native Human Von Willebrand Factor (VWF) protein ab88533 is a multimeric plasma glycoprotein and its molecular weight can range from 260 kDa (monomer) to >10,000 kDa (multimers).
Ensure the validity of your result using our native human VWF protein ab88533 as a positive control in SDS-PAGE.
Required thawing procedure:
- Remove the vial from frozen storage and place it into a 37°C water bath
- Leave the vial in the water bath undisturbed for two minutes after the disappearance of the last of the frozen material
- Remove the vial from the water bath and mix by gentle agitation or gentle mixing with a pipette.
If a precipitate is observed, continue to warm the vial in the 37°C water bath for an additional 2 to 3 minutes and mix again
Check out our protein gel staining guide for SDS-PAGE here
The VWF protein ab88533 is prepared from plasma shown to be non reactive for anti-HIV-1/2, HIV-1 antigen(s), HBsAg, STS, anti-HCV, anti-HBcore and anti-HTLV I & II.
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1 product image
SDS-PAGE - Native Human Von Willebrand Factor protein (ab88533)
SDS-PAGE analysis of ab88533 for 1ug protein.
Novex 4-12% Bis-Tris Gel
NR= non-reduced; R = reduced
Downloads
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- Visit the general protocols
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