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Native mouse Factor X protein is a Mouse Full Length protein, in the 41 to 481 aa range, expressed in Native, with >95% purity and suitable for SDS-PAGE, FuncS.

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Key facts

Purity
>95% SDS-PAGE
Expression system
Native
Tags
Tag free
Applications
SDS-PAGE, FuncS
Biologically active
Yes

Reactivity data

Application
SDS-PAGE
Reactivity
Reacts
Dilution info
-
Notes

-

Application
FuncS
Reactivity
Reacts
Dilution info
-
Notes

-

Associated Products

Select an associated product type

2 products for Alternative Product

Target data

Function

Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting (By similarity). Factor Xa activates pro-inflammatory and pro-fibrotic signaling pathways in a protease-activated receptor (PAR)-dependent manner (By similarity).

Alternative names

Recommended products

Native mouse Factor X protein is a Mouse Full Length protein, in the 41 to 481 aa range, expressed in Native, with >95% purity and suitable for SDS-PAGE, FuncS.

Key facts

Purity
>95% SDS-PAGE
Expression system
Native
Applications
SDS-PAGE, FuncS
Biological activity
86.8 U/mg determined by Factor X clotting assay (1 unit is equivalent to the Factor X activity in 1 ml normal plasma based on a Human plasma standard curve). 86.8 U/mg determined by Factor X clotting assay (1 unit is equivalent to the Factor X activity in 1 ml normal plasma based on a Human plasma standard curve).
Accession
O88947-1
Animal free
No
Species
Mouse
Concentration
Loading...
Storage buffer

Constituents: 50% Glycerol (glycerin, glycerine)

Sequence info

Amino acid sequence

Accession
O88947
Protein length
Full Length
Predicted molecular weight
58.9 kDa
Amino acids
41 to 481
Nature
Native

Specifications

Form
Liquid
Additional notes

ab96742 is isolated from fresh frozen plasma by a combination of conventional techniques and immunoaffinity chromatography.

General info

Function

Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting (By similarity). Factor Xa activates pro-inflammatory and pro-fibrotic signaling pathways in a protease-activated receptor (PAR)-dependent manner (By similarity).

Sequence similarities

Belongs to the peptidase S1 family.

Post-translational modifications

The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium.

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

This product is an active protein and may elicit a biological response in vivo, handle with caution.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

Factor X also known as Stuart-Prower Factor is a critical component in the coagulation cascade. It has a molecular weight of approximately 59 kDa and is expressed mainly in the liver. This serine protease plays an important role in the conversion of prothrombin to thrombin an essential step in blood clot formation. Factor X circulates in the plasma as an inactive zymogen and becomes activated to its enzyme form factor Xa in response to specific physiological signals.

Biological function summary

Factor X contributes significantly to the coagulation process by activating prothrombin into thrombin. It is not part of a larger complex but functions closely with other components of the coagulation cascade to maintain hemostasis. Factor X interacts with calcium ions and phospholipids on the surface of platelets enhancing its enzymatic activity. This activation ensures proper regulation of blood clotting preventing excessive bleeding or uncontrolled clot formation.

Pathways

Factor X is central to both the intrinsic and extrinsic coagulation pathways. It interacts with proteins such as factor VIIa in the extrinsic pathway and factor IXa in the intrinsic pathway both pathways leading to the activation of factor Xa. In turn factor Xa is key in the common pathway which combines inputs from the intrinsic and extrinsic pathways to produce thrombin essential for fibrin clot formation.

Associated diseases and disorders

Factor X is associated with bleeding disorders such as hemophilia and liver disease. Deficiencies or dysfunctions in factor X result in inadequate clot formation leading to prolonged bleeding episodes. Furthermore increased factor X activity as in cases of thrombophilia can raise the risk of abnormal blood clots. Factor X works alongside proteins like factor V with both deficiencies playing roles in hemophilia. Monitoring factor X activity is important in diagnosing and managing these coagulation-related conditions.

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