Skip to main content

Native Mouse Fibrinogen protein (Active) is a Mouse Full Length protein, in the 1 to 481 aa range, expressed in Native, with >95% purity and suitable for SDS-PAGE, FuncS.

Be the first to review this product! Submit a review

Publications

Key facts

Purity
>95% SDS-PAGE
Expression system
Native
Tags
Tag free
Applications
SDS-PAGE, FuncS
Biologically active
Yes

Sequence

This product is comprised of multiple sequences see

Amino acid sequence 1

M R H L W L L L L L C V F S V Q T Q A A D D D Y D E P T D S L D A R G H R P V D R R K E E P P S L R P A P P P I S G G G Y R A R P A K A T A N Q K K V E R R P P D A G G C L H A D T D M G V L C P T G C T L Q Q T L L N Q E R P I K S S I A E L N N N I Q S V S D T S S V T F Q Y L T L L K D M W K K K Q A Q V K E N E N V I N E Y S S I L E D Q R L Y I D E T V N D N I P L N L R V L R S I L E D L R S K I Q K L E S D I S A Q M E Y C R T P C T V S C N I P V V S G K E C E E I I R K G G E T S E M Y L I Q P D T S I K P Y R V Y C D M K T E N G G W T V I Q N R Q D G S V D F G R K W D P Y K K G F G N I A T N E D A K K Y C G L P G E Y W L G N D K I S Q L T R M G P T E L L I E M E D W K G D K V K A H Y G G F T V Q N E A S K Y Q V S V N K Y K G T A G N A L M D G A S Q L V G E N R T M T I H N G M F F S T Y D R D N D G W V T T D P R K Q C S K E D G G G W W Y N R C H A A N P N G R Y Y W G G L Y S W D M S K H G T D D G V V W M N W K G S W Y S M R R M S M K I R P F F P Q Q

Reactivity data

Application
SDS-PAGE
Reactivity
Reacts
Dilution info
-
Notes

-

Application
FuncS
Reactivity
Reacts
Dilution info
-
Notes

-

Associated Products

Select an associated product type

2 products for Alternative Product

Target data

Function

Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix (By similarity). Fibrin has a major function in hemostasis as one of the primary components of blood clots (By similarity). In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization (By similarity). Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo (By similarity). Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway (PubMed:19332769). Maternal fibrinogen is essential for successful pregnancy (By similarity). Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage (By similarity). May also facilitate the immune response via both innate and T-cell mediated pathways (By similarity).

Additional Targets

Fgb, Fibrinogen gamma chain

Alternative names

Fibrinogen gamma chain, Fgg

Recommended products

Native Mouse Fibrinogen protein (Active) is a Mouse Full Length protein, in the 1 to 481 aa range, expressed in Native, with >95% purity and suitable for SDS-PAGE, FuncS.

Key facts

Purity
>95% SDS-PAGE
Expression system
Native
Applications
SDS-PAGE, FuncS
Biological activity
>80% Clottable in a thrombin based assay.
Accession
Q8VCM7-1
Animal free
No
Species
Mouse
Concentration
Loading...
Storage buffer

pH: 7.4
Constituents: 0.59% Sodium citrate

Sequence info

Amino acid sequence 1

M R H L W L L L L L C V F S V Q T Q A A D D D Y D E P T D S L D A R G H R P V D R R K E E P P S L R P A P P P I S G G G Y R A R P A K A T A N Q K K V E R R P P D A G G C L H A D T D M G V L C P T G C T L Q Q T L L N Q E R P I K S S I A E L N N N I Q S V S D T S S V T F Q Y L T L L K D M W K K K Q A Q V K E N E N V I N E Y S S I L E D Q R L Y I D E T V N D N I P L N L R V L R S I L E D L R S K I Q K L E S D I S A Q M E Y C R T P C T V S C N I P V V S G K E C E E I I R K G G E T S E M Y L I Q P D T S I K P Y R V Y C D M K T E N G G W T V I Q N R Q D G S V D F G R K W D P Y K K G F G N I A T N E D A K K Y C G L P G E Y W L G N D K I S Q L T R M G P T E L L I E M E D W K G D K V K A H Y G G F T V Q N E A S K Y Q V S V N K Y K G T A G N A L M D G A S Q L V G E N R T M T I H N G M F F S T Y D R D N D G W V T T D P R K Q C S K E D G G G W W Y N R C H A A N P N G R Y Y W G G L Y S W D M S K H G T D D G V V W M N W K G S W Y S M R R M S M K I R P F F P Q Q
Accession
E9PV24
Protein length
Full Length
Amino acids
1 to 481
Nature
Native

Amino acid sequence 2

M L S L R V T C L I L S V A S T V W T T D T E D K G E F L S E G G G V R G P R V V E R H Q S Q C K D S D W P F C S D D D W N H K C P S G C R M K G L I D E A N Q D F T N R I N K L K N S L F D F Q R N N K D S N S L T R N I M E Y L R G D F A N A N N F D N T Y G Q V S E D L R R R I E I L R R K V I E K A Q Q I Q A L Q S N V R A Q L I D M K R L E V D I D I K I R S C K G S C S R A V N R E I N L Q D Y E G H Q K Q L Q Q V I A K E L L P T K D R Q Y L P A L K M S P V P D L V P G S F K S Q L Q E A P P E W K A L T E M R Q M R M E L E R P G K D G G S R G D S P G D S R G D S R G D F A T R G P G S K A E N P T N P G P G G S G Y W R P G N S G S G S D G N R N P G T T G S D G T G D W G T G S P R P G S D S G N F R P A N P N W G V F S E F G D S S S P A T R K E Y H T G K A V T S K G D K E L L I G K E K V T S S G T S T T H R S C S K T I T K T V T G P D G R R E V V K E V I T S D D G S D C G D A T E L D I S H S F S G S L D E L S E R H P D L S G F F D N H F G L I S P N F K E F G S K T H S D S D I L T N I E D P S S H V P E F S S S S K T S T V K K Q V T K T Y K M A D E A G S E A H R E G E T R N T K R G R A R A R P T R D C D D V L Q T Q T S G A Q N G I F S I K P P G S S K V F S V Y C D Q E T S L G G W L L I Q Q R M D G S L N F N R T W Q D Y K R G F G S L N D K G E G E F W L G N D Y L H L L T L R G S V L R V E L E D W A G K E A Y A E Y H F R V G S E A E G Y A L Q V S S Y R G T A G D A L V Q G S V E E G T E Y T S H S N M Q F S T F D R D A D Q W E E N C A E V Y G G G W W Y N S C Q A A N L N G I Y Y P G G T Y D P R N N S P Y E I E N G V V W V P F R G A D Y S L R A V R M K I R P L V G Q
Accession
E9PV24
Protein length
Full Length
Amino acids
1 to 789
Nature
Native

Amino acid sequence 3

M S W S L Q P P S F L L C C L L L L F S P T G L A Y V A T R D N C C I L D E R F G S F C P T T C G I A D F L S S Y Q T D V D N D L R T L E D I L F R A E N R T T E A K E L I K A I Q V Y Y N P D Q P P K P G M I D S A T Q K S K K M V E E I V K Y E A L L L T H E T S I R Y L Q E I Y N S N N Q K I T N L K Q K V A Q L E A Q C Q E P C K D S V Q I H D T T G K D C Q E I A N K G A K E S G L Y F I R P L K A K Q Q F L V Y C E I D G S G N G W T V L Q K R I D G S L D F K K N W I Q Y K E G F G H L S P T G T T E F W L G N E K I H L I S M Q S T I P Y A L R I Q L K D W N G R T S T A D Y A M F R V G P E S D K Y R L T Y A Y F I G G D A G D A F D G Y D F G D D P S D K F F T S H N G M Q F S T W D N D N D K F E G N C A E Q D G S G W W M N K C H A G H L N G V Y H Q G G T Y S K S S T T N G F D D G I I W A T W K S R W Y S M K E T T M K I I P F N R L S I G E G Q Q H H M G G S K Q A G D V
Accession
Q8VCM7
Protein length
Full Length
Amino acids
1 to 436
Nature
Native

Specifications

Form
Liquid
Additional notes

Prepared from fresh Mouse plasma using several chromatographic steps. Plasminogen depleted by lysine affinity chromatography.

General info

Function

Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix (By similarity). Fibrin has a major function in hemostasis as one of the primary components of blood clots (By similarity). In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization (By similarity). Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo (By similarity). Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway (PubMed:19332769). Maternal fibrinogen is essential for successful pregnancy (By similarity). Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage (By similarity). May also facilitate the immune response via both innate and T-cell mediated pathways (By similarity).

Post-translational modifications

Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers (By similarity).

Storage

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

This product is an active protein and may elicit a biological response in vivo, handle with caution.

Notes

Extinction coefficient: 1.51

Host species: Mouse

MW: 340.00 kDa

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

0 product images

    Downloads

    Product protocols

    For this product, it's our understanding that no specific protocols are required. You can:

    Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

    For licensing inquiries, please contact partnerships@abcam.com