Native Parainfluenza Virus type 1 protein

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Parainfluenza Virus type 1 also known as Human Parainfluenza Virus 1 (HPIV-1) is an enveloped single-stranded RNA virus belonging to the family Paramyxoviridae. It plays an important role in respiratory tract infections and has a mass estimated around 15-18 kilobases. HPIV-1 primarily expresses its proteins in the epithelial cells of the respiratory tract where it facilitates viral replication and spread. Key surface proteins include hemagglutinin-neuraminidase (HN) and fusion protein (F) which assist in viral attachment and entry into host cells.

Biological function summary

Parainfluenza Virus type 1 affects the mucosa of the upper and lower respiratory tract leading to conditions such as croup in children. It is not part of a larger complex but functions independently to hijack host cellular machinery for replication. The HN protein binds to sialic acid-containing receptors on the host cell surface while the F protein enables the merging of viral and cellular membranes a process essential for viral entry.

Pathways

The mechanics of Parainfluenza Virus type 1 integrate into immune evasion and viral propagation pathways. The virus down-regulates the host's interferon response which is critical for antiviral activity. Proteins like the V protein interact with host signaling molecules to inhibit interferon production ensuring virus survival. This interaction connects HPIV-1 to essential immune regulation pathways influencing antiviral responses.

Associated diseases and disorders

Parainfluenza Virus type 1 is notably associated with respiratory diseases such as croup and bronchiolitis. These disorders result from the virus's ability to induce inflammation and mucus production in the airway. The F protein of HPIV-1 contributes to the fusion of infected cells forming syncytia which exacerbate respiratory symptoms. This viral mechanism highlights the virus's potential impact on respiratory health and the body's response to infection.