Native Pig Myelin Basic Protein is a Pig Full Length protein, expressed in Native, with >90% purity and suitable for SDS-PAGE.
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- Cell reports 37:1098922021Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CL substrate degradome.Applications:Unspecified applicationReactive species:Unspecified reactive speciesIsabel Pablos,Yoan Machado,Hugo C Ramos de Jesus,Yasir Mohamud,Reinhild Kappelhoff,Cecilia Lindskog,Marli Vlok,Peter A Bell,Georgina S Butler,Peter M Grin,Quynh T Cao,Jenny P Nguyen,Nestor Solis,Srinivas Abbina,Wioletta Rut,John C Vederas,Laszlo Szekely,Attila Szakos,Marcin Drag,Jayachandran N Kizhakkedathu,Karen Mossman,Jeremy A Hirota,Eric Jan,Honglin Luo,Arinjay Banerjee,Christopher M OverallPubMed 34672947
Key facts
- Purity
- >90% Densitometry
- Expression system
- Native
- Tags
- Tag free
- Applications
- SDS-PAGE
- Biologically active
- No
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
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Target data
Function
Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity).
Alternative names
Myelin basic protein, MBP
Recommended products
Native Pig Myelin Basic Protein is a Pig Full Length protein, expressed in Native, with >90% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >90% Densitometry
- Expression system
- Native
- Tags
- Tag free
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- P81558
- Animal free
- No
- Species
- Pig
- Concentration
- Storage buffer
pH: 6.5
Specifications
- Form
- Liquid
- Additional notes
Native pig Myelin Basic Protein was extracted under acidic conditions and further purified by cation chromatography.
General info
- Function
Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity).
- Sequence similarities
Belongs to the myelin basic protein family.
- Post-translational modifications
As in other animals, several charge isomers may be produced as a result of optional post-translational modifications, such as phosphorylation of serine or threonine residues, deamidation of glutamine or asparagine residues, citrullination and methylation of arginine residues.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Stable for 12 months at -20°C
Notes
ab64311 (Myelin Basic Protein protein) can be utilized as a substrate for the following active protein kinases:
ab51441 (Active human MNK2 full length protein)
Recombinant human Flt3 / CD135 protein ab55709 (Active human Flt3 / CD135 protein fragment)
Recombinant human Myosin IIIB protein ab55716 (Active human Myosin IIIB protein fragment)
Recombinant human MAP4K5 protein ab56636 (Active human MAP4K5 full length protein)
Recombinant mouse Aurora A protein ab60327 (Active mouse Aurora A full length protein)
ab60342 (Active human NEK2 full length protein)
Recombinant human NEK6 protein ab60698 (Active human NEK6 full length protein)
Recombinant human IRAK4 protein ab60860 (Active human IRAK4 full length protein)
Recombinant human HIPK1 protein ab60867 (Active human HIPK1 protein fragment)
Recombinant human RIP2 protein ab60879 (Active human RIP2 protein)
Recombinant human STK3/MST-2 protein ab60885 (Active human STK3 full length protein)
Recombinant human TAOK2 protein ab61426 (Active human TAO kinase 2 protein fragment)
Recombinant human TAOK1 protein ab63169 (Active human TAOK1 protein fragment)
Recombinant human DAP Kinase 1 protein ab63191 (Active human DAP Kinase 1 protein fragment)
Recombinant human ZIP Kinase protein ab63192 (Active human ZIP Kinase full length protein)
Recombinant human MEK1 protein ab63209 (Active human MEK1 full length protein)
Recombinant human CDK7 + Cyclin H + MNAT1 protein ab64303 (Active human CDK7 + Cyclin H + MNAT1 full length protein)
Recombinant human HIPK4 protein ab69925 (Active human HIPK4 full length protein)
Recombinant human TSSK2 protein ab70075 (Active human TSSK2 full length protein)
Recombinant human ROR2 protein ab70614 (Active human ROR2 protein fragment)
Recombinant human MUSK protein ab71693 (Active MUSK protein fragment)
Recombinant human PBK/SPK protein ab85275 (Active human PBK full length protein)
Recombinant human NAK/TBK1 protein ab85276 (Active human NAK full length protein)
Recombinant human SRPK2 protein ab85293 (Active human SRPK2 full length protein)
Recombinant human SRPK1 protein ab85295 (Active human SRPK1 full length protein)
Recombinant human MEKK3 protein ab85297 (Active human MEKK3 full length protein)
Recombinant human MEKK2 protein ab85299 (Active human MEKK2 full length protein)
Recombinant human FIST protein ab85601 (Active human HIPK3 protein fragment)
Recombinant human CLK3 protein ab85759 (Active human CLK3 full length protein)
Recombinant human PKR protein ab85838 (Active human PKR protein fragment)
Recombinant human TTK/Mps1 protein ab89589 (Active human Mps1 full length protein)
Recombinant human STK33 protein ab89591 (Active human STK33 full length protein)
Recombinant human TAK1 + TAB1 protein ab89692 (Active human TAK1 + TAB1 protein fragment)
Recombinant human RIPK5 protein ab89694 (Active human RIPK5 full length protein)
Recombinant human NEK3 protein ab89758 (Active human NEK3 full length protein)
Recombinant human ZAK protein ab89852 (Active human ZAK full length protein)
Recombinant human ICK protein ab101774 (Active human ICK full length protein)
Recombinant human MAP4K4/NIK protein ab101775 (Active human MAP4K4 protein fragment)
Recombinant human MAP3K1 protein ab104027 (Active human MEKK1 protein fragment)
Recombinant human NFkB Inducing Kinase NIK protein ab105210 (Active human NFkB Inducing Kinase NIK protein fragment)
Recombinant human ERK1 protein ab105904 (Active human ERK1 full length protein)
Recombinant human SPAK protein ab107696 (Active human STK39 full length protein)
Recombinant human NLK protein ab107700 (Active human NLK full length protein)
Recombinant human MAP4K1/HPK1 protein ab107953 (Active human MAP4K1 protein)
Recombinant human TNIK protein ab119725 (Active human TNIK protein fragment)
Recombinant human NEK11 protein ab125544 (Active human NEK11 full length protein)
Recombinant mouse HIPK2 protein ab125553 (Active mouse HIPK2 protein fragment)
Recombinant human MAP3K9 protein ab125554 (Active human MAP3K9 protein fragment)
Recombinant human PLK4 protein ab125558 (Active human PLK4 protein fragment)
Recombinant human MLK2 protein ab125562 (Active human MLK2 protein fragment)
Recombinant human RIP3 protein (Tagged) ab125566 (Active human RIP3 full length protein)
Recombinant human YANK2 protein ab125574 (Active human YANK2 full length protein)
Recombinant human STK25 protein ab125588 (Active human STK25 full length protein)
Recombinant human NEK9 protein ab125614 (Active human NEK9 protein fragment)
Recombinant human ULK2 protein ab125622 (Active human ULK2 protein fragment)
Recombinant human MLK3 protein ab125630 (Active human MLK3 protein fragment)
Recombinant mouse TTBK2 protein ab125631 (Active mouse Tau tubulin kinase 2 protein fragment)
Recombinant human ULK1 protein ab125656 (Active human ULK1 protein fragment)
Recombinant human ERK5 protein ab126913 (Active human ERK5 full length protein)
Recombinant human BMPR2 protein ab126926 (Active human BMPR2 protein fragment)
Recombinant human NEK5 protein ab133140 (Active human NEK5 protein fragment)
Recombinant Mouse NEK1 protein ab133146 (Active human NEK1 protein fragment)
Recombinant human STK36 protein ab139615 (Active human STK36 protein fragment)
Recombinant human ROR1 protein ab140807 (Active human ROR1 protein fragment)
Recombinant Human Smad3 protein ab151882 (Human Smad3 full length protein)
Recombinant human ERK2 protein ab155812 (Active ERK2 full length protein)
Recombinant human LIM Kinase 1 protein ab174066 (Active human LIMK1 protein fragment)
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The myelin basic protein also referred to as MBP or MBP protein plays an important mechanical role in the central nervous system. It is a major component in the formation and stability of the myelin sheath which wraps around nerve fibers to ensure efficient neural signaling. The molecular weight of MBP can vary due to alternative splicing; one common form has a mass of about 18.5 kDa. MBP is expressed predominantly in oligodendrocytes within the brain and spinal cord where it helps form the myelin sheath. MBP2 is another variant that may be mentioned in some contexts.
- Biological function summary
MBP is not just a passive structural element; it binds and interacts with lipids and other proteins to maintain the compact structure of the myelin sheath. MBP forms part of a complex that includes various other proteins and lipids ensuring the stability and function of myelin. Misfolding or altered expression of MBP can compromise myelin integrity affecting the insulation of neural pathways and signal transmission.
- Pathways
MBP is an essential component in the pathways of myelination and neural plasticity. It plays a role in the signaling pathways that stimulate the development and maintenance of the myelin sheath. The protein interacts with other elements of the myelin sheath such as proteolipid protein (PLP) and myelin-associated glycoprotein (MAG) to coordinate its formation and repair processes.
- Associated diseases and disorders
MBP is linked closely to multiple sclerosis (MS) and other demyelinating conditions. Damage to or autoimmunity against MBP leads to the degradation of the myelin sheath contributing to the neurological symptoms in MS. The protein interacts with elements of the immune system with autoantibodies targeting MBP often found in MS patients. Another disorder associated with MBP dysfunction is Charcot-Marie-Tooth disease where abnormal MBP expression and structure can impact nerve function.
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1 product image
SDS-PAGE - Native Pig Myelin Basic Protein (ab64311)
ab64311 on SDS-PAGE, MW 21.5kDa.
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