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AB189308

Neuropilin 1 peptide

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(2 Publications)

Neuropilin 1 peptide is a Synthetic blocking peptide.

View Alternative Names

CD304, NRP, VEGF165R, NRP1, Neuropilin-1, Vascular endothelial cell growth factor 165 receptor

Key facts

Purity

Whole antiserum

Tags

Tag free

Applications

BL

applications

Biologically active

No

Accession

O14786

Animal free

No

Carrier free

No

Species

Human

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Complementary Products

Primary Antibodies

AB81321

Anti-Neuropilin 1 antibody [EPR3113]

RabMAb|Recombinant|KO Validated|20ul selling size

Flow Cytometry (Intracellular) - Anti-Neuropilin 1 antibody [EPR3113] (AB81321)

  • 4
  • 31
Proteins & Peptides

AB221023

Recombinant human Neuropilin 1 protein (Fc Chimera Active)

Bioactive

Functional Studies - Recombinant human Neuropilin 1 protein (Fc Chimera Active) (AB221023)

  • 0
  • 0
Primary Antibodies

AB202643

Alexa Fluor® 647 Anti-Integrin beta 1 antibody [12G10]

KO Validated

Flow Cytometry - Alexa Fluor® 647 Anti-Integrin beta 1 antibody [12G10] (AB202643)

  • 0
  • 0
Primary Antibodies

AB8227

Anti-beta Actin antibody - Loading Control

BOND RX™ Validated|Lab Essentials

Western blot - Anti-beta Actin antibody - Loading Control (AB8227)

  • 5
  • 104
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "BL": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

Blocking peptide for ab81321.

- First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
- If the peptide doesn't dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
- Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
- Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
- Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

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Sequence info

[{"sequence":null,"proteinLength":null,"predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":0,"aminoAcidStart":0,"nature":"Synthetic","expressionSystem":null,"accessionNumber":"O14786","tags":[]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
-20°C
False
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Specifications

Form

Lyophilized

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General info

Function

Cell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins (PubMed : 10688880, PubMed : 9288753, PubMed : 9529250). Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage (PubMed : 19805273). It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB (PubMed : 10688880, PubMed : 19805273, PubMed : 9288753, PubMed : 9529250). Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR (PubMed : 30623799).. (Microbial infection) Acts as a host factor for human coronavirus SARS-CoV-2 infection. Recognizes and binds to CendR motif RRAR on SARS-CoV-2 spike protein S1 which enhances SARS-CoV-2 infection.. Isoform 2. Binds VEGF-165 and may inhibit its binding to cells (PubMed : 10748121, PubMed : 26503042). May induce apoptosis by sequestering VEGF-165 (PubMed : 10748121). May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.

Sequence similarities

Belongs to the neuropilin family.

Subcellular localisation

Mitochondrion membrane

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Product protocols

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Target data

Cell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins (PubMed : 10688880, PubMed : 9288753, PubMed : 9529250). Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage (PubMed : 19805273). It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB (PubMed : 10688880, PubMed : 19805273, PubMed : 9288753, PubMed : 9529250). Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR (PubMed : 30623799).. (Microbial infection) Acts as a host factor for human coronavirus SARS-CoV-2 infection. Recognizes and binds to CendR motif RRAR on SARS-CoV-2 spike protein S1 which enhances SARS-CoV-2 infection.. Isoform 2. Binds VEGF-165 and may inhibit its binding to cells (PubMed : 10748121, PubMed : 26503042). May induce apoptosis by sequestering VEGF-165 (PubMed : 10748121). May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.
See full target information NRP1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Cell metabolism 33:1565-1576.e5 PubMed34081912

2021

SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment.

Applications

Unspecified application

Species

Unspecified reactive species

Chien-Ting Wu,Peter V Lidsky,Yinghong Xiao,Ivan T Lee,Ran Cheng,Tsuguhisa Nakayama,Sizun Jiang,Janos Demeter,Romina J Bevacqua,Charles A Chang,Robert L Whitener,Anna K Stalder,Bokai Zhu,Han Chen,Yury Goltsev,Alexandar Tzankov,Jayakar V Nayak,Garry P Nolan,Matthias S Matter,Raul Andino,Peter K Jackson

The European journal of neuroscience 49:1529-1543 PubMed30589468

2019

Expression of the axon-guidance protein receptor Neuropilin 1 is increased in the spinal cord and decreased in muscle of a mouse model of amyotrophic lateral sclerosis.

Applications

Unspecified application

Species

Unspecified reactive species

Sonja Körner,Nadine Thau-Habermann,Ekaterini Kefalakes,Franziska Bursch,Susanne Petri
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Product promise

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