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AB224861

Recombinant B. pertussis Pertactin autotransporter protein (Tagged)

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Recombinant B. pertussis Pertactin autotransporter protein (Tagged) is a Bordetella pertussis Tohama I Fragment protein, in the 632 to 910 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

omp69A, BP1054, prn, Pertactin autotransporter, P.93

1 Images
SDS-PAGE - Recombinant B. pertussis Pertactin autotransporter protein (Tagged) (AB224861)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant B. pertussis Pertactin autotransporter protein (Tagged) (AB224861)

SDS-PAGE - Recombinant B. pertussis Pertactin autotransporter protein (His tag) (ab224861) (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) analysis of ab224861 with 5% enrichment gel and 15% separation gel.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P14283

Animal free

No

Carrier free

No

Species

Bordetella pertussis Tohama I

Storage buffer

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"ALSKRLGELRLNPDAGGAWGRGFAQRQQLDNRAGRRFDQKVAGFELGADHAVAVAGGRWHLGGLAGYTRGDRGFTGDGGGHTDSVHVGGYATYIADSGFYLDATLRASRLENDFKVAGSDGYAVKGKYRTHGVGASLEAGRRFTHADGWFLEPQAELAVFRAGGGAYRAANGLRVRDEGGSSVLGRLGLEVGKRIELAGGRQVQPYIKASVLQEFDGAGTVHTNGIAHRTELRGTRAELGLGMAAALGRGHSLYASYEYSKGPKLAMPWTFHAGYRYSW","proteinLength":"Fragment","predictedMolecularWeight":"45.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":910,"aminoAcidStart":632,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P14283","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Pertactin autotransporter also known as Pertactin protein is an important protein in the pathogenesis of Bordetella pertussis. It functions mechanically as an autotransporter protein involved in forming one of the surface adhesins utilized by the bacterium. This protein with a mass of approximately 93 kDa gets expressed on the outer membrane of Bordetella pertussis. Pertactin enables the bacterium to adhere to host tissues playing a role in facilitating infection.
Biological function summary

Pertactin contributes to the virulence of Bordetella pertussis by assisting in establishing infection within the respiratory tract. It functions as part of the overall adhesive machinery of the bacterium but does not form a defined complex with other proteins. Pertactin interacts with host cell receptors to mediate attachment which helps Bordetella pertussis to colonize and persist in the host.

Pathways

Pertactin functions alongside other virulence factors in Bordetella pertussis like the fimbriae and filamentous hemagglutinin. These proteins together participate in the bacterial pathogenesis pathway enabling effective colonization of the host environment. The bacterial signal transduction pathway modulates the expression of Pertactin and related virulence factors coordinating the pathogen's response to the host's immune environment.

Pertactin is closely associated with whooping cough (pertussis) a severe respiratory illness. Its role in adhering to host cells makes it an important target in understanding the infection process and developing vaccines. Pertactin's activity connects it with other proteins like the pertussis toxin further enhancing the pathogen's ability to cause disease by disrupting host cellular processes and evading the immune response.
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Specifications

Form

Liquid

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General info

Function

Agglutinogen that binds to eukaryotic cells; a process mediated by the R-G-D sequence. Pertactin may have a role in bacterial adhesion, and thus play a role in virulence. May contribute to the disease state of whooping cough.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Agglutinogen that binds to eukaryotic cells; a process mediated by the R-G-D sequence. Pertactin may have a role in bacterial adhesion, and thus play a role in virulence. May contribute to the disease state of whooping cough.
See full target information prn

Additional targets

Pertactin autotransporter
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Product promise

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For full details, please see our Terms & Conditions
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