Recombinant Bovine Coronavirus Hemagglutinin esterase protein (His tag)
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Recombinant Bovine Coronavirus Hemagglutinin esterase protein (His tag) is a Bovine coronavirus Mebus Full Length protein, expressed in Yeast, with >90%, suitable for SDS-PAGE.
View Alternative Names
2b, HE, Hemagglutinin-esterase, HE protein, E3 glycoprotein
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Bovine Coronavirus Hemagglutinin esterase protein (His tag) (AB226232)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
HE plays an important role in the life cycle of enveloped viruses particularly within the viral entry mechanism. It is often not part of a larger complex but works alongside other viral proteins such as the spike protein in coronaviruses. Its dual enzymatic functions allow for both attachment to host cell receptors and the cleavage of sialic acids which are critical for efficient viral infection and spread. These actions ensure the virus can efficiently infect host cells and efficiently propagate.
Pathways
HE involves itself in the sialic acid-mediated viral entry pathway in host cells. Its functional role is significant in this pathway ensuring successful replication and spread. HE works closely with other viral proteins such as neuraminidase involved in the release of progeny viruses. Together these proteins facilitate critical steps in the viral replication cycle contributing to the infectivity and transmission of the virus.
Specifications
Form
Liquid
General info
Function
Structural protein that makes short spikes at the surface of the virus. Contains receptor binding and receptor-destroying activities. Mediates de-O-acetylation of N-acetyl-4-O-acetylneuraminic acid, which is probably the receptor determinant recognized by the virus on the surface of erythrocytes and susceptible cells. This receptor-destroying activity is important for virus release as it probably helps preventing self-aggregation and ensures the efficient spread of the progeny virus from cell to cell. May serve as a secondary viral attachment protein for initiating infection, the spike protein being the major one. May become a target for both the humoral and the cellular branches of the immune system.
Sequence similarities
Belongs to the influenza type C/coronaviruses hemagglutinin-esterase family.
Post-translational modifications
N-glycosylated in the host RER.
Product protocols
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Target data
Product promise
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