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AB238225

Recombinant Cow Pregnancy associated glycoprotein 1 (His tag)

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Recombinant Cow Pregnancy associated glycoprotein 1 (His tag) is a Cow Full Length protein, in the 54 to 380 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

Pregnancy-associated glycoprotein 1, PAG 1, Pregnancy-specific protein B, PSP-B

3 Images
Mass Spectrometry - Recombinant Cow Pregnancy associated glycoprotein 1 (His tag) (AB238225)
  • Mass Spec

Supplier Data

Mass Spectrometry - Recombinant Cow Pregnancy associated glycoprotein 1 (His tag) (AB238225)

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of ab238225 could indicate that this peptide derived from E.coli-expressed Bos taurus (Bovine) Pregnancy associated glycoprotein 1.

Mass Spectrometry - Recombinant Cow Pregnancy associated glycoprotein 1 (His tag) (AB238225)
  • Mass Spec

Supplier Data

Mass Spectrometry - Recombinant Cow Pregnancy associated glycoprotein 1 (His tag) (AB238225)

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of ab238225 could indicate that this peptide derived from E.coli-expressed Bos taurus (Bovine) Pregnancy associated glycoprotein 1.

SDS-PAGE - Recombinant Cow Pregnancy associated glycoprotein 1 (His tag) (AB238225)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Cow Pregnancy associated glycoprotein 1 (His tag) (AB238225)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) analysis with 5% enrichment gel and 15% separation gel of ab238225.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q29432

Animal free

No

Carrier free

No

Species

Cow

Storage buffer

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"RGSNLTTHPLRNIKDLVYMGNITIGTPPQEFQVVFDTASSDLWVPSDFCTSPACSTHVRFRHLQSSTFRLTNKTFRITYGSGRMKGVVVHDTVRIGNLVSTDQPFGLSIEEYGFEGRIYDGVLGLNYPNISFSGAIPIFDKLKNQRAISEPVFAFYLSKDEREGSVVMFGGVDHRYYEGELNWVPLIQAGDWSVHMDRISIERKIIACSDGCKALVDTGTSDIVGPRRLVNNIHRLIGAIPRGSEHYVPCSEVNTLPSIVFTINGINYPVPGRAYILKDDRGRCYTTFQENRVSSSTETWYLGDVFLRLYFSVFDRGNDRIGLARAV","proteinLength":"Full Length","predictedMolecularWeight":"40.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":380,"aminoAcidStart":54,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q29432","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Pregnancy-associated glycoprotein 1 (PAG1) is a protein mainly associated with pregnancy in mammals. It belongs to the aspartic proteinase family and is encoded by the PAG1 gene. The protein has a molecular mass of approximately 50 kDa. PAG1 is expressed predominantly in the placenta and can also be found in serum. Its expression begins soon after conception and continues throughout pregnancy making it a useful marker for detecting early pregnancy in certain livestock species.
Biological function summary

PAG1 functions as a member of the aspartic proteinase family though its specific enzymatic activity in vivo remains not completely understood. It is involved in the formation and maintenance of the placenta possibly playing a role in trophoblastic cell invasion and immune modulation during pregnancy. PAG1 does not typically form large protein complexes but its presence in the placenta suggests a tight interaction with the developing fetal environment.

Pathways

PAG1 interacts with several molecular signaling pathways that involve placental development and fetal-maternal immune tolerance. One significant pathway is its role in the regulation of maternal immune response where PAG1 may contribute to the modulation of cytokine release. It is also involved with proteins like interferon tau which are important for successful pregnancy recognition and maintenance.

PAG1 is often linked to reproductive health challenges such as abnormal placental development and pre-eclampsia. Abnormal expression patterns of PAG1 can indicate placental dysfunction and irregularities during pregnancy. The protein may interact with factors like vascular endothelial growth factor (VEGF) which plays a role in angiogenesis and vascular function during pregnancy leading to its association with conditions involving placental insufficiency.
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Specifications

Form

Liquid

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General info

Function

Appears to be proteolytically inactive.

Sequence similarities

Belongs to the peptidase A1 family.

Post-translational modifications

N-Glycosylated; the glycans terminate in either N-acetyl-galactosamine (GalNAc) or N-acetyllactosamine (PubMed:15822115, PubMed:17071780). Terminal GalNAc on Asn-linked glycans is greatly reduced prior to parturition while lactosamine-type N-glycans remain unaltered (PubMed:17071780).

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Product protocols

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Target data

Appears to be proteolytically inactive.
See full target information Pregnancy-associated glycoprotein 1
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