Recombinant Cynomolgus monkey Albumin protein is a Cynomolgus monkey Full Length protein, in the 25 to 608 aa range, expressed in Mammalian, with >90% purity and suitable for SDS-PAGE.
Images
Publications
Filter by
- mAbs 15:21602292023TRYBE®: an Fc-free antibody format with three monovalent targeting arms engineered for long in vivo half-life.Applications:Unspecified applicationReactive species:Unspecified reactive speciesEmma Davé,Oliver Durrant,Neha Dhami,Joanne Compson,Janice Broadbridge,Sophie Archer,Asher Maroof,Kevin Whale,Karelle Menochet,Pierre Bonnaillie,Emily Barry,Gavin Wild,Claude Peerboom,Pallavi Bhatta,Mark Ellis,Matthew Hinchliffe,David P Humphreys,Sam P HeywoodPubMed 36788124
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Mammalian
- Tags
- DDDDK tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
D T H K S E V A H R F K D L G E E H F K G L V L V A F S Q Y L Q Q C P F E E H V K L V N E V T E F A K T C V A D E S A E N C D K S L H T L F G D K L C T V A T L R E T Y G E M A D C C A K Q E P E R N E C F L Q H K D D N P N L P P L V R P E V D V M C T A F H D N E A T F L K K Y L Y E V A R R H P Y F Y A P E L L F F A A R Y K A A F A E C C Q A A D K A A C L L P K L D E L R D E G K A S S A K Q R L K C A S L Q K F G D R A F K A W A V A R L S Q K F P K A E F A E V S K L V T D L T K V H T E C C H G D L L E C A D D R A D L A K Y M C E N Q D S I S S K L K E C C D K P L L E K S H C L A E V E N D E M P A D L P S L A A D Y V E S K D V C K N Y A E A K D V F L G M F L Y E Y A R R H P D Y S V M L L L R L A K A Y E A T L E K C C A A A D P H E C Y A K V F D E F Q P L V E E P Q N L V K Q N C E L F E Q L G E Y K F Q N A L L V R Y T K K V P Q V S T P T L V E V S R N L G K V G A K C C K L P E A K R M P C A E D Y L S V V L N R L C V L H E K T P V S E K V T K C C T E S L V N R R P C F S A L E L D E A Y V P K A F N A E T F T F H A D M C T L S E K E K Q V K K Q T A L V E L V K H K P K A T K E Q L K G V M D N F A A F V E K C C K A D D K E A C F A E E G P K F V A A S Q A A L A
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (By similarity). Does not prevent iron uptake by the bacterial siderophore aerobactin (By similarity).
Alternative names
Qlv-U347A-C12, Qlv-U377A-G8, ALB, Albumin
Recommended products
Recombinant Cynomolgus monkey Albumin protein is a Cynomolgus monkey Full Length protein, in the 25 to 608 aa range, expressed in Mammalian, with >90% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Mammalian
- Tags
- DDDDK tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- A2V9Z4-1
- Animal free
- No
- Species
- Cynomolgus monkey
- Concentration
- Storage buffer
pH: 7.2 - 7.4
Constituents: PBS, 6% Trehalose
Sequence info
Amino acid sequence
- D T H K S E V A H R F K D L G E E H F K G L V L V A F S Q Y L Q Q C P F E E H V K L V N E V T E F A K T C V A D E S A E N C D K S L H T L F G D K L C T V A T L R E T Y G E M A D C C A K Q E P E R N E C F L Q H K D D N P N L P P L V R P E V D V M C T A F H D N E A T F L K K Y L Y E V A R R H P Y F Y A P E L L F F A A R Y K A A F A E C C Q A A D K A A C L L P K L D E L R D E G K A S S A K Q R L K C A S L Q K F G D R A F K A W A V A R L S Q K F P K A E F A E V S K L V T D L T K V H T E C C H G D L L E C A D D R A D L A K Y M C E N Q D S I S S K L K E C C D K P L L E K S H C L A E V E N D E M P A D L P S L A A D Y V E S K D V C K N Y A E A K D V F L G M F L Y E Y A R R H P D Y S V M L L L R L A K A Y E A T L E K C C A A A D P H E C Y A K V F D E F Q P L V E E P Q N L V K Q N C E L F E Q L G E Y K F Q N A L L V R Y T K K V P Q V S T P T L V E V S R N L G K V G A K C C K L P E A K R M P C A E D Y L S V V L N R L C V L H E K T P V S E K V T K C C T E S L V N R R P C F S A L E L D E A Y V P K A F N A E T F T F H A D M C T L S E K E K Q V K K Q T A L V E L V K H K P K A T K E Q L K G V M D N F A A F V E K C C K A D D K E A C F A E E G P K F V A A S Q A A L A
- Accession
- A2V9Z4
- Protein length
- Full Length
- Predicted molecular weight
- 69 kDa
- Amino acids
- 25 to 608
- Nature
- Recombinant
- Tags
- DDDDK tag C-Terminus
Specifications
- Form
- Liquid
- Additional notes
nan
General info
- Function
Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (By similarity). Does not prevent iron uptake by the bacterial siderophore aerobactin (By similarity).
- Sequence similarities
Belongs to the ALB/AFP/VDB family.
- Post-translational modifications
Phosphorylated by FAM20C in the extracellular medium.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Albumin also known as ALB is a major plasma protein with a molecular mass of approximately 66.5 kDa. It predominantly gets synthesized in the liver and found abundantly in blood plasma. Albumin serves multiple functions including maintaining osmotic pressure and acting as a carrier protein for various endogenous substances like hormones fatty acids and bilirubin.
- Biological function summary
Albumin plays a critical role in transporting small molecules like metabolites and drugs through the circulatory system. It is not a part of any complex but functions independently to bind transport and release various ligands. Albumin's affinity for hydrophobic molecules makes it essential for they to be solubilized in blood for proper metabolism and excretion.
- Pathways
More than five binding sites on albumin facilitate its role in the fatty acid metabolism and renin-angiotensin system pathways. In fatty acid metabolism albumin interacts with transport proteins carrying fatty acids to tissues for energy production. Additionally during the renin-angiotensin system albumin modulates blood pressure through its interaction with angiotensin II which can influence vasoconstriction.
- Associated diseases and disorders
Researchers link albumin with nephrotic syndrome and liver cirrhosis. In nephrotic syndrome low levels of albumin (albumin low) can cause edema due to imbalanced osmotic pressure. In liver cirrhosis a reduction in albumin synthesis signifies liver damage. Albumin's interaction with proteins like angiotensin II correlates with complications such as hypertension further establishing the protein's role in health and disease contexts.
Product promise
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
1 product image
SDS-PAGE - Recombinant Cynomolgus monkey Albumin protein (ab267858)
SDS-PAGE analysis of recombinant albumin macaca fascicularis protein (ab267858).
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com