Recombinant Cynomolgus monkey DR3/LARD protein (Fc Chimera) is a Human Fragment protein, in the 20 to 203 aa range, expressed in HEK 293, with >90% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
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Key facts
- Purity
- >90% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- Fc tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
Q G G T Q S P R C D C A G D F H K K N G V F C C R G C P A G H Y L K A P C T E P C G N S T C L L C P Q D T F L A W E N H H N S E C A R C Q A C D E Q A S Q V A L E N C S A V A D T R C G C K P G W F V E C Q V S Q C V S S S P F Y C Q P C L D C R A L H R H T R L L C S R R D T D C G T C L P G F Y E H D D G C V S C P T P P P S L S G A P W G A V Q S A V P L S V A G G R V G
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
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Target data
Function
Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.
Alternative names
APO3, DDR3, DR3, TNFRSF12, WSL, WSL1, UNQ455/PRO779, TNFRSF25, Tumor necrosis factor receptor superfamily member 25, Apo-3, Apoptosis-inducing receptor AIR, Apoptosis-mediating receptor DR3, Apoptosis-mediating receptor TRAMP, Death receptor 3, Lymphocyte-associated receptor of death, Protein WSL, Protein WSL-1, LARD
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Recombinant Cynomolgus monkey DR3/LARD protein (Fc Chimera) is a Human Fragment protein, in the 20 to 203 aa range, expressed in HEK 293, with >90% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Key facts
- Purity
- >90% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- Fc tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q93038-1
- Animal free
- No
- Species
- Human
- Reconstitution
- Reconstitute at 100 µg/mL in water
- Concentration
- Storage buffer
pH: 7.4
Constituents: Sodium chloride, 5% Trehalose, 0.75% Glycine, 0.61% Tris
Sequence info
Amino acid sequence
- Q G G T Q S P R C D C A G D F H K K N G V F C C R G C P A G H Y L K A P C T E P C G N S T C L L C P Q D T F L A W E N H H N S E C A R C Q A C D E Q A S Q V A L E N C S A V A D T R C G C K P G W F V E C Q V S Q C V S S S P F Y C Q P C L D C R A L H R H T R L L C S R R D T D C G T C L P G F Y E H D D G C V S C P T P P P S L S G A P W G A V Q S A V P L S V A G G R V G
- Protein length
- Fragment
- Predicted molecular weight
- 46.3 kDa
- Amino acids
- 20 to 203
- Nature
- Recombinant
- Tags
- Fc tag C-Terminus
Specifications
- Form
- Lyophilized
General info
- Function
Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.
- Post-translational modifications
(Microbial infection) Glycosylated at Arg-352 by enteropathogenic E.coli protein NleB1.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Avoid freeze / thaw cycle
Notes
This product was previously labelled as DR3
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The DR3 receptor also known as LARD (Lymphocyte Apoptosis-Related Receptor Domain) is a member of the TNF receptor superfamily. This protein also referred to as the DR3 protein or LARD protein is involved in mediating apoptotic signals. DR3 is expressed predominantly in lymphoid tissues and plays an important role in immune system regulation. DR3 protein has an approximate mass of 65 kDa. Scientists study DR3 in various models including cyno RNA and protein monkey models to gain better understanding of its function and expression.
- Biological function summary
DR3 functions significantly in the immune response by modulating apoptosis. It forms part of a complex with other proteins leading to the activation of signaling pathways that result in cell death. The binding of its ligand TL1A to DR3 initiates a series of downstream effects that influence T-cell and other immune cell activities. LARD target has a functional correlation with the regulation of immune response and the maintenance of homeostasis in immune cell populations.
- Pathways
DR3 receptor mediates signals primarily in two significant pathways: the NF-kB pathway and the MAPK pathway. These pathways play a role in transducing signals that lead to inflammation and immune responses. DR3 interacts with other proteins such as TRADD and RIPK1 facilitating the propagation of signals through these pathways. The engagement of DR3 in these pathways highlights its regulatory influence over immune cell survival and function.
- Associated diseases and disorders
DR3 plays an important role in autoimmune diseases and inflammatory disorders. Dysregulation of DR3 receptor and its signaling pathways can contribute to conditions like rheumatoid arthritis and inflammatory bowel disease. There is a notable connection between dysfunction in DR3 signaling and altered interactions with pro-inflammatory proteins such as TNF-alpha which can exacerbate these conditions. Understanding DR3's role helps in developing therapeutic approaches to manage these disorders.
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1 product image
SDS-PAGE - Recombinant Cynomolgus monkey DR3/LARD protein (Fc Chimera) (ab220534)
SDS-PAGE analysis of ab220534 stained overnight with Coomassie Blue.
The reduced protein migrates as 50 kDa.
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