Recombinant Cynomolgus monkey Prealbumin protein (His tag) is a Cynomolgus monkey Full Length protein, in the 21 to 147 aa range, expressed in Mammalian, with >90% purity and suitable for SDS-PAGE, MS.
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Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Mammalian
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
G P T G V D E S K C P L M V K V L D A V R G S P A V N V A V N V F K K A A D E T W A P F A S G K T S E S G E L H G L T T E E E F V E G I Y K V E I D T K S Y W K S L G I S P F H E H A E V V F T A N D S G P R H Y T I A A L L S P Y S Y S T T A V V T N P K E
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
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Target data
Function
Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain (By similarity).
Alternative names
QccE-10711, QccE-14396, TTR, Transthyretin, Prealbumin
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Recombinant Cynomolgus monkey Prealbumin protein (His tag) is a Cynomolgus monkey Full Length protein, in the 21 to 147 aa range, expressed in Mammalian, with >90% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Mammalian
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- Q8HXW1-1
- Animal free
- No
- Species
- Cynomolgus monkey
- Concentration
- Storage buffer
pH: 7.2 - 7.4
Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)
Sequence info
Amino acid sequence
- G P T G V D E S K C P L M V K V L D A V R G S P A V N V A V N V F K K A A D E T W A P F A S G K T S E S G E L H G L T T E E E F V E G I Y K V E I D T K S Y W K S L G I S P F H E H A E V V F T A N D S G P R H Y T I A A L L S P Y S Y S T T A V V T N P K E
- Accession
- Q8HXW1
- Protein length
- Full Length
- Predicted molecular weight
- 17.7 kDa
- Amino acids
- 21 to 147
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain (By similarity).
- Sequence similarities
Belongs to the transthyretin family.
- Post-translational modifications
Sulfonation of the reactive cysteine Cys-30 enhances the stability of the native conformation of TTR, avoiding misassembly of the protein leading to amyloid formation.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Prealbumin also known as transthyretin is a protein with a molecular mass of approximately 55 kDa. The liver primarily synthesizes prealbumin and it is present in the bloodstream. Functionally prealbumin transports thyroxine and retinol-binding protein-retinol complex facilitating the distribution of these molecules to target tissues. As such it plays an integral role in maintaining retinol and thyroid hormone homeostasis.
- Biological function summary
Prealbumin interacts with retinol-binding protein to form a complex essential for vitamin A transportation. This complex prevents renal filtration of retinol-binding protein thereby conserving vitamin A in circulation. The protein's role extends beyond transport as it influences neurophysiological processes due to its ability to bind thyroid hormones and affect gene expression related to metabolism. Prealbumin is primarily a part of the thyroxine-transferring complex reinforcing its critical position in hormonal and vitamin dynamics.
- Pathways
Prealbumin's role in the thyroxine-binding globulin pathway highlights its importance in the endocrine system. Another pathway where prealbumin contributes significantly is the vitamin A metabolic pathway. In these pathways prealbumin maintains functional relationships with proteins like retinol-binding protein and thyroxine-binding globulin which jointly modulate thyroid hormone transport and vitamin A dynamics across cellular membranes.
- Associated diseases and disorders
Prealbumin directly associates with familial amyloid polyneuropathy and malnutrition. Familial amyloid polyneuropathy involves the deposition of prealbumin-derived amyloid fibrils in peripheral nerves impacting neuron function. In malnutrition decreased prealbumin levels serve as a biomarker reflecting poor nutritional status. Clinically prealbumin's relation to retinol-binding protein and thyroid hormone levels facilitates its use in diagnosing and monitoring these conditions.
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3 product images
SDS-PAGE - Recombinant Cynomolgus monkey Prealbumin protein (His tag) (ab239566)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel analysis of ab239566.
Mass Spectrometry - Recombinant Cynomolgus monkey Prealbumin protein (His tag) (ab239566)
Based on the SEQUEST from database of Mammalian Cell host and target protein, the LC-MS/MS Analysis result of ab239566 could indicate that this peptide derived from Mammalian Cell-expressed Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TTR.
Mass Spectrometry - Recombinant Cynomolgus monkey Prealbumin protein (His tag) (ab239566)
Based on the SEQUEST from database of Mammalian Cell host and target protein, the LC-MS/MS Analysis result of ab239566 could indicate that this peptide derived from Mammalian Cell-expressed Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) TTR.
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