Recombinant Cynomolgus monkey TREM2 protein is a Full Length protein, in the 19 to 174 aa range, <= 0.005 EU/µg endotoxin level and suitable for SDS-PAGE, MS, HPLC.
H N T T V F Q G V E G Q S L Q V S C P Y D S M K H W G R R K A W C R Q L G E K G P C Q R V V S T H N L W L L S F L R R R N G S T A I T D D T L G G T L T I T L R N L Q P H D A G F Y Q C Q S L H G S E A D T L R K V L V E V L A D P L D H R D A G D L W V P G E S E S F E D A H V E H S I S R S L L E G E I P F P P T S
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Application HPLC | Reactivity Reacts | Dilution info - | Notes - |
Recombinant Cynomolgus monkey TREM2 protein is a Full Length protein, in the 19 to 174 aa range, <= 0.005 EU/µg endotoxin level and suitable for SDS-PAGE, MS, HPLC.
pH: 7.4
Constituents: 10.26% Trehalose, 0.727% Dibasic monohydrogen potassium phosphate, 0.248% Potassium phosphate monobasic
SDS-PAGE>=95% Purity.
Full-length mature chain lacking the signal peptide and pro-peptide.
TREM2 also known as Triggering Receptor Expressed on Myeloid Cells 2 functions as a receptor with an important role in the immune system. This protein weighing about 230-290 kDa mostly expresses in myeloid cells which include macrophages monocytes and microglia. It serves as an important player in signaling for the activation of these cells. Researchers often study TREM2's functions through various species including cynomolgus monkeys to understand its implications better.
TREM2 significantly influences immune responses by participating in cellular clearance functions such as phagocytosis. It forms a receptor complex with DAP12 which transduces signals leading to the activation of immune responses. TREM2 aids in regulating inflammatory responses and ensures the maintenance of tissue homeostasis in healthy and diseased states. Its role extends to the control of lipid metabolism particularly in the central nervous system.
Scientific studies link TREM2 to the immune-inflammatory pathway and the neurodegenerative pathway. Within these pathways TREM2 interacts notably with proteins such as DAP12 and SYK. Through these interactions TREM2 contributes to signaling cascades that modulate inflammation and neurodegenerative processes within the brain supporting cellular communication and survival.
TREM2's functionality connects significantly with Alzheimer's disease and various inflammatory conditions. In Alzheimer's disease mutations in TREM2 alter its normal activity potentially increasing neuroinflammation and advancing disease progression. Additionally collaborations between TREM2 and ApoE proteins further highlight its involvement in lipid regulation within neurodegenerative conditions. Understanding TREM2’s role can pave the way for targeted therapeutic approaches in these disorders.
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