JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB43040

Recombinant Cytomegalovirus Glycoprotein B

Be the first to review this product! Submit a review

|

(6 Publications)

Recombinant Cytomegalovirus Glycoprotein B is a Human herpesvirus 5 strain AD169 Fragment protein, expressed in Escherichia coli, with >95%, suitable for ELISA, WB.

View Alternative Names

UL55, gB, Envelope glycoprotein B, CMV glycoprotein B, Glycoprotein B, HCMV, HHV5 glycoprotein B, UL55

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

Tag free

Applications

ELISA, WB

applications

Biologically active

No

Accession

P06473

Animal free

No

Carrier free

No

Species

Human herpesvirus 5 strain AD169

Storage buffer

pH: 7.2 Constituents: 50% Glycerol (glycerin, glycerine), 0.395% Tris HCl, 0.0292% EDTA

storage-buffer

style
left-column

Complementary Products

Reagents, Controls & Accessories

AB116029

Prestained Protein Ladder - Extra broad molecular weight (5 - 245 kDa)

SDS-PAGE - Prestained Protein Ladder - Extra broad molecular weight (5 - 245 kDa) (AB116029)

  • 5
  • 1
Proteins & Peptides

AB43046

Recombinant HSV2 gD protein

  • 0
  • 0
Proteins & Peptides

AB43042

Recombinant Cytomegalovirus UL80a protein

  • 0
  • 0
Primary Antibodies

AB6506

Anti-HSV1 + HSV2 gB antibody [10B7]

Immunocytochemistry/ Immunofluorescence - Anti-HSV1 + HSV2 gB antibody [10B7] (AB6506)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"","proteinLength":"Fragment","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":0,"aminoAcidStart":0,"nature":"Recombinant","expressionSystem":null,"accessionNumber":"P06473","tags":[]}]
style
left-column

Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column
style
left-column

Specifications

Form

Liquid

Additional notes

Sepharose derived purification.

style
left-column

General info

Function

Envelope glycoprotein that plays a role in host cell entry, cell to-cell virus transmission, and fusion of infected cells. May be involved in the initial attachment via binding to heparan sulfate together with the gM/gN complex that binds heparin with higher affinity. Interacts with host integrin ITGB1, PDGFRA and EGFR that likely serve as postattachment entry receptors. Also participates in the fusion of viral and cellular membranes leading to virus entry into the host cell. Membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL.

Sequence similarities

Belongs to the herpesviridae glycoprotein B family.

Post-translational modifications

A proteolytic cleavage by host furin generates two subunits that remain linked by disulfide bonds.

Subcellular localisation

Host endosome membrane

style
left-column

Product protocols

style
left-column

Target data

Envelope glycoprotein that plays a role in host cell entry, cell to-cell virus transmission, and fusion of infected cells. May be involved in the initial attachment via binding to heparan sulfate together with the gM/gN complex that binds heparin with higher affinity. Interacts with host integrin ITGB1, PDGFRA and EGFR that likely serve as postattachment entry receptors. Also participates in the fusion of viral and cellular membranes leading to virus entry into the host cell. Membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL.
See full target information gB
style
left-column

Publications (6)

Recent publications for all applications. Explore the full list and refine your search

Cell 186:1417-1431.e20 PubMed37001502

2023

Cytotoxic CD4 T cells eliminate senescent cells by targeting cytomegalovirus antigen.

Applications

Unspecified application

Species

Unspecified reactive species

Tatsuya Hasegawa,Tomonori Oka,Heehwa G Son,Valeria S Oliver-García,Marjan Azin,Thomas M Eisenhaure,David J Lieb,Nir Hacohen,Shadmehr Demehri

Nature communications 14:1041 PubMed36823200

2023

The cytomegalovirus gB/MF59 vaccine candidate induces antibodies against an antigenic domain controlling cell-to-cell spread.

Applications

Unspecified application

Species

Unspecified reactive species

A C Gomes,I A Baraniak,A Lankina,Z Moulder,P Holenya,C Atkinson,G Tang,T Mahungu,F Kern,P D Griffiths,M B Reeves

Frontiers in immunology 13:1083230 PubMed36591233

2022

HCMV carriage in the elderly diminishes anti-viral functionality of the adaptive immune response resulting in virus replication at peripheral sites.

Applications

Unspecified application

Species

Unspecified reactive species

Emma L Davies,Mahlaqua Noor,Eleanor Y Lim,Charlotte J Houldcroft,Georgina Okecha,Claire Atkinson,Matthew B Reeves,Sarah E Jackson,Mark R Wills

PLoS pathogens 15:e1008064 PubMed31841557

2019

IgG3 enhances neutralization potency and Fc effector function of an HIV V2-specific broadly neutralizing antibody.

Applications

Unspecified application

Species

Unspecified reactive species

Simone I Richardson,Bronwen E Lambson,Andrew R Crowley,Arman Bashirova,Cathrine Scheepers,Nigel Garrett,Salim Abdool Karim,Nonhlanhla N Mkhize,Mary Carrington,Margaret E Ackerman,Penny L Moore,Lynn Morris

Journal of pharmaceutical and biomedical analysis 156:372-378 PubMed29758495

2018

A rapid magnetic particle-based enzyme immunoassay for human cytomegalovirus glycoprotein B quantification.

Applications

Unspecified application

Species

Unspecified reactive species

F Pires,M Julia Arcos-Martinez,A Cristina Dias-Cabral,Juan C Vidal,Juan R Castillo

Scientific reports 7:937 PubMed28428537

2017

Human Cytomegalovirus Induces Cellular and Humoral Virus-specific Immune Responses in Humanized BLT Mice.

Applications

ELISA

Species

Unspecified reactive species

Lindsey B Crawford,Rebecca Tempel,Daniel N Streblow,Craig Kreklywich,Patricia Smith,Louis J Picker,Jay A Nelson,Patrizia Caposio
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com