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AB43044

Recombinant Cytomegalovirus ICP36 protein

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Recombinant Cytomegalovirus ICP36 protein is a Human herpesvirus 5 strain AD169 Fragment protein, expressed in Escherichia coli, with >95%, suitable for ELISA, WB.

Key facts

Purity

>95% SDS-PAGE

Sepharose derived purification.

Expression system

Escherichia coli

Tags

Tag free

Applications

WB, ELISA

applications

Biologically active

No

Accession

P16790-1

Animal free

No

Carrier free

No

Species

Human herpesvirus 5 strain AD169

Storage buffer

Constituents: 50% Glycerol (glycerin, glycerine), 0.79% Tris HCl, 0.348% Sodium chloride, 0.307% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"linker":null,"sequence":"","proteinLength":"Fragment","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":0,"aminoAcidStart":0,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":null,"tags":[]}]
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Properties and storage information

Form
Liquid
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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General info

Function

Accessory subunit of the DNA polymerase that plays an essential role in viral DNA replication and acts by increasing the processivity of polymerization (PubMed : 20538862, PubMed : 20739543, PubMed : 33967989). Forms dimers that binds to double-stranded DNA and UL54 specifically to stimulates long chain DNA synthesis efficiently. Plays an important role in maintaining the structure of viral replication compartments by interacting with host nucleolin/NUC (PubMed : 22318319). In addition, suppresses innate immune responses through effects on host IRF3 and NF-kappa-B. Mechanistically, interfere with the binding of IRF3 and the p65 NF-kappa-B subunit to the promoters of antiviral genes, thereby inhibiting the expression of these genes (PubMed : 30867312).

Sequence similarities

Belongs to the herpesviridae polymerase accessory protein family.

Post-translational modifications

Phosphorylated by UL97 on serine residues, phosphorylation seems important for UL44 nuclear entry but does not directly affect its role in replication.. Sumoylated. Sumoylation on Lys-410 increases viral DNA replication.

Subcellular localisation

Host nucleus

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Product protocols

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Target data

Accessory subunit of the DNA polymerase that plays an essential role in viral DNA replication and acts by increasing the processivity of polymerization (PubMed : 20538862, PubMed : 20739543, PubMed : 33967989). Forms dimers that binds to double-stranded DNA and UL54 specifically to stimulates long chain DNA synthesis efficiently. Plays an important role in maintaining the structure of viral replication compartments by interacting with host nucleolin/NUC (PubMed : 22318319). In addition, suppresses innate immune responses through effects on host IRF3 and NF-kappa-B. Mechanistically, interfere with the binding of IRF3 and the p65 NF-kappa-B subunit to the promoters of antiviral genes, thereby inhibiting the expression of these genes (PubMed : 30867312).
See full target information UL44

Additional targets

Cytomegalovirus ICP36

Alternative Names

DNA polymerase processivity factor, Polymerase accessory protein, Protein ICP36, PAP, UL44, PAP, HCMV, HHV 5, ICP36, Human Hepesvirus 5, DNA polymerase accessory protein, DNA polymerase processivity factor
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Product promise

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