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AB54103

Recombinant Cytomegalovirus pp65 protein (297-510aa)

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Recombinant Cytomegalovirus pp65 protein (297-510aa) is a Human herpesvirus 5 strain AD169 Fragment protein, in the 297 to 510 aa range, expressed in Escherichia coli, with >95%, suitable for ELISA, WB.

View Alternative Names

65 kDa phosphoprotein, pp65, 65 kDa matrix phosphoprotein, Phosphoprotein UL83, Tegument protein UL83, UL83

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

P06725

Animal free

No

Carrier free

No

Species

Human herpesvirus 5 strain AD169

Storage buffer

pH: 7.2 - 7.6 Preservative: 0.1% Sodium azide Constituents: 50% Glycerol (glycerin, glycerine), 9% Urea, 0.395% Tris HCl, 0.0292% EDTA

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"","proteinLength":"Fragment","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":510,"aminoAcidStart":297,"nature":"Recombinant","expressionSystem":null,"accessionNumber":null,"tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Specifications

Form

Liquid

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General info

Function

Counteracts the host antiviral immune response when activated and phosphorylated, by preventing host IRF3 from entering the nucleus (PubMed : 15452220). Inhibits also the type I interferon production by inactivating the enzymatic activity of DNA sensor CGAS without affecting STING1 (PubMed : 29263269). Participates in the transactivation of viral major immediate-early genes by the recruitment of host IFI16 to the promoters pf these genes (PubMed : 20504932).

Sequence similarities

Belongs to the herpesviridae pp65 family.

Post-translational modifications

Phosphorylation may play a role in the localization of the protein.

Subcellular localisation

Host nucleus

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Product protocols

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Target data

Counteracts the host antiviral immune response when activated and phosphorylated, by preventing host IRF3 from entering the nucleus (PubMed : 15452220). Inhibits also the type I interferon production by inactivating the enzymatic activity of DNA sensor CGAS without affecting STING1 (PubMed : 29263269). Participates in the transactivation of viral major immediate-early genes by the recruitment of host IFI16 to the promoters pf these genes (PubMed : 20504932).
See full target information UL83
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