Recombinant Cytomegalovirus pp65 protein is a Human herpesvirus 5 strain AD169 Full Length protein, expressed in Escherichia coli, with >95% purity and suitable for ELISA, WB.
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
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Counteracts the host antiviral immune response when activated and phosphorylated, by preventing host IRF3 from entering the nucleus (PubMed:15452220). Inhibits also the type I interferon production by inactivating the enzymatic activity of DNA sensor CGAS without affecting STING1 (PubMed:29263269). Participates in the transactivation of viral major immediate-early genes by the recruitment of host IFI16 to the promoters pf these genes (PubMed:20504932).
UL83
65 kDa phosphoprotein, pp65, 65 kDa matrix phosphoprotein, Phosphoprotein UL83, Tegument protein UL83, UL83
Recombinant Cytomegalovirus pp65 protein is a Human herpesvirus 5 strain AD169 Full Length protein, expressed in Escherichia coli, with >95% purity and suitable for ELISA, WB.
pH: 8
Constituents: 48.048% Urea, 0.394% Tris HCl, 0.039% 2-Mercaptoethanol
Sepharose derived purification.
Counteracts the host antiviral immune response when activated and phosphorylated, by preventing host IRF3 from entering the nucleus (PubMed:15452220). Inhibits also the type I interferon production by inactivating the enzymatic activity of DNA sensor CGAS without affecting STING1 (PubMed:29263269). Participates in the transactivation of viral major immediate-early genes by the recruitment of host IFI16 to the promoters pf these genes (PubMed:20504932).
Belongs to the herpesviridae pp65 family.
Phosphorylation may play a role in the localization of the protein.
Specificity: Immunoreactive with sera of CMV-infected individuals.
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