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AB43041

Recombinant Cytomegalovirus pp65 protein

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(6 Publications)

Recombinant Cytomegalovirus pp65 protein is a Human herpesvirus 5 strain AD169 Full Length protein, expressed in Escherichia coli, with >95%, suitable for ELISA, WB.

View Alternative Names

65 kDa phosphoprotein, pp65, 65 kDa matrix phosphoprotein, Phosphoprotein UL83, Tegument protein UL83, UL83, 65 kDa phosphoprotein, pp65, 65 kDa matrix phosphoprotein, Phosphoprotein UL83, Tegument protein UL83, UL83

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

6x His tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

P06725

Animal free

No

Carrier free

No

Species

Human herpesvirus 5 strain AD169

Storage buffer

pH: 8 Constituents: 48.048% Urea, 0.394% Tris HCl, 0.039% 2-Mercaptoethanol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

Specificity: Immunoreactive with sera of CMV-infected individuals.
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Sequence info

[{"sequence":"","proteinLength":"Full Length","predictedMolecularWeight":"62.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":0,"aminoAcidStart":0,"nature":"Recombinant","expressionSystem":null,"accessionNumber":null,"tags":[{"tag":"6x His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Specifications

Form

Liquid

Additional notes

Sepharose derived purification.

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General info

Function

Counteracts the host antiviral immune response when activated and phosphorylated, by preventing host IRF3 from entering the nucleus (PubMed : 15452220). Also inhibits the type I interferon production by inactivating the enzymatic activity of DNA sensor CGAS without affecting STING1 (PubMed : 29263269, PubMed : 40243337). Participates in the transactivation of viral major immediate-early genes by the recruitment of host IFI16 to the promoters pf these genes (PubMed : 20504932).

Sequence similarities

Belongs to the herpesviridae pp65 family.

Post-translational modifications

Phosphorylation may play a role in the localization of the protein.. S-nitrosylated. Nitrosylation decreases the inhibition of host CGAS.

Subcellular localisation

Host nucleus

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Product protocols

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Target data

Counteracts the host antiviral immune response when activated and phosphorylated, by preventing host IRF3 from entering the nucleus (PubMed : 15452220). Also inhibits the type I interferon production by inactivating the enzymatic activity of DNA sensor CGAS without affecting STING1 (PubMed : 29263269, PubMed : 40243337). Participates in the transactivation of viral major immediate-early genes by the recruitment of host IFI16 to the promoters pf these genes (PubMed : 20504932).
See full target information UL83

Additional targets

UL83
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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

PloS one 20:e0321392 PubMed40193826

2025

Assessment of antigen immunogenicity formulated in minigenes transfected into antigen-presenting cells.

Applications

Unspecified application

Species

Unspecified reactive species

María A Villota-Alava,María A Alfaro-Marenco,Carlos A Clavijo-Ramírez,Manuel A Patarroyo,Carlos A Parra-López

BMC gastroenterology 23:333 PubMed37759163

2023

Zerumbone ameliorates the inflammatory response and organ damage in severe acute pancreatitis via the ROS/NF-κB pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Fengmei Zhang,Dongjia Xu

iScience 26:105928 PubMed36619367

2023

Continuous population-level monitoring of SARS-CoV-2 seroprevalence in a large European metropolitan region.

Applications

Unspecified application

Species

Unspecified reactive species

Marc Emmenegger,Elena De Cecco,David Lamparter,Raphaël P B Jacquat,Julien Riou,Dominik Menges,Tala Ballouz,Daniel Ebner,Matthias M Schneider,Itzel Condado Morales,Berre Doğançay,Jingjing Guo,Anne Wiedmer,Julie Domange,Marigona Imeri,Rita Moos,Chryssa Zografou,Leyla Batkitar,Lidia Madrigal,Dezirae Schneider,Chiara Trevisan,Andres Gonzalez-Guerra,Alessandra Carrella,Irina L Dubach,Catherine K Xu,Georg Meisl,Vasilis Kosmoliaptsis,Tomas Malinauskas,Nicola Burgess-Brown,Ray Owens,Stephanie Hatch,Juthathip Mongkolsapaya,Gavin R Screaton,Katharina Schubert,John D Huck,Feimei Liu,Florence Pojer,Kelvin Lau,David Hacker,Elsbeth Probst-Müller,Carlo Cervia,Jakob Nilsson,Onur Boyman,Lanja Saleh,Katharina Spanaus,Arnold von Eckardstein,Dominik J Schaer,Nenad Ban,Ching-Ju Tsai,Jacopo Marino,Gebhard F X Schertler,Nadine Ebert,Volker Thiel,Jochen Gottschalk,Beat M Frey,Regina R Reimann,Simone Hornemann,Aaron M Ring,Tuomas P J Knowles,Milo A Puhan,Christian L Althaus,Ioannis Xenarios,David I Stuart,Adriano Aguzzi

PLoS pathogens 15:e1007914 PubMed31356650

2019

Identification of adipocyte plasma membrane-associated protein as a novel modulator of human cytomegalovirus infection.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaohua Ye,Xun Gui,Daniel C Freed,Zhiqiang Ku,Leike Li,Yuanzhi Chen,Wei Xiong,Xuejun Fan,Hang Su,Xi He,Richard R Rustandi,John W Loughney,Ningning Ma,Amy S Espeseth,Jian Liu,Hua Zhu,Dai Wang,Ningyan Zhang,Tong-Ming Fu,Zhiqiang An

Scientific reports 9:9998 PubMed31292492

2019

Characterisation of a human antibody that potentially links cytomegalovirus infection with systemic lupus erythematosus.

Applications

Unspecified application

Species

Unspecified reactive species

Jie Ying Jacklyn Neo,Seng Yin Kelly Wee,Isabelle Bonne,Sen Hee Tay,Manfred Raida,Vojislav Jovanovic,Anna-Marie Fairhurst,Jinhua Lu,Brendon J Hanson,Paul A MacAry

Nature medicine 25:977-987 PubMed31110348

2019

IFN-γ-independent immune markers of Mycobacterium tuberculosis exposure.

Applications

Unspecified application

Species

Unspecified reactive species

Lenette L Lu,Malisa T Smith,Krystle K Q Yu,Corinne Luedemann,Todd J Suscovich,Patricia S Grace,Adam Cain,Wen Han Yu,Tanya R McKitrick,Douglas Lauffenburger,Richard D Cummings,Harriet Mayanja-Kizza,Thomas R Hawn,W Henry Boom,Catherine M Stein,Sarah M Fortune,Chetan Seshadri,Galit Alter
View all publications
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