Recombinant Dog Cationic Trypsin protein (His tag) is a Dog Full Length protein, in the 24 to 246 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
>90% SDS-PAGE
Escherichia coli
His tag N-Terminus
SDS-PAGE
No
I V G G Y T C S R N S V P Y Q V S L N S G Y H F C G G S L I N S Q W V V S A A H C Y K S R I Q V R L G E Y N I A V S E G G E Q F I N A A K I I R H P R Y N A N T I D N D I M L I K L S S P A T L N S R V S A I A L P K S C P A A G T Q C L I S G W G N T Q S I G Q N Y P D V L Q C L K A P I L S D S V C R N A Y P G Q I S S N M M C L G Y M E G G K D S C Q G D S G G P V V C N G E L Q G V V S W G A G C A Q K G K P G V S P K V C K Y V S W I Q Q T I A A N
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Cationic trypsin, TRY1, TRYP1, PRSS1, TRP1
Recombinant Dog Cationic Trypsin protein (His tag) is a Dog Full Length protein, in the 24 to 246 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
>90% SDS-PAGE
Escherichia coli
His tag N-Terminus
SDS-PAGE
No
No
Dog
pH: 7.2 - 7.4
Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)
I V G G Y T C S R N S V P Y Q V S L N S G Y H F C G G S L I N S Q W V V S A A H C Y K S R I Q V R L G E Y N I A V S E G G E Q F I N A A K I I R H P R Y N A N T I D N D I M L I K L S S P A T L N S R V S A I A L P K S C P A A G T Q C L I S G W G N T Q S I G Q N Y P D V L Q C L K A P I L S D S V C R N A Y P G Q I S S N M M C L G Y M E G G K D S C Q G D S G G P V V C N G E L Q G V V S W G A G C A Q K G K P G V S P K V C K Y V S W I Q Q T I A A N
Full Length
39.6 kDa
24 to 246
Recombinant
His tag N-Terminus
Liquid
Belongs to the peptidase S1 family.
Blue Ice
-20°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
This supplementary information is collated from multiple sources and compiled automatically.
Cationic Trypsin also known as Trypsin-1 or PRSS1 is a serine protease enzyme with a mass of approximately 24 kDa. It exists in human pancreas in the form of inactive trypsinogen ready for secretion into the small intestine. Within the intestine trypsinogen converts into active trypsin. This enzyme cleaves peptide bonds particularly involving lysine and arginine residues and plays a critical role in protein digestion.
Cationic trypsin acts to facilitate the breakdown of dietary proteins into amino acids and smaller peptides that cells can absorb. It does not act as part of a large complex but operates independently to perform its function during the digestive process. Trypsin also assists in activating other digestive enzymes such as chymotrypsinogen and procarboxypeptidase thereby amplifying its digestive function.
Cationic trypsin plays a significant role in the proteolytic enzyme cascade that facilitates digestion within the gastrointestinal tract. It activates the zymogen forms of various enzymes including chymotrypsin and elastase so that it facilitates the complete breakdown of proteins into absorbable units. This pathway is critical for efficient nutrient absorption linking closely to other enzymes like pepsin in the stomach.
Altered activity or expression of cationic trypsin connects closely to pancreatitis particularly hereditary pancreatitis. Mutations in the PRSS1 gene result in trypsinogen that resists inactivation causing pancreas damage. Additionally it relates to certain forms of pancreatic cancer due to its role in pancreatic functions and interactions with other proteins like alpha-1 antitrypsin (SERPINA1) which normally helps in regulating trypsin activity.
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