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AB225587

Recombinant Dog Cationic Trypsin protein (His tag)

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Recombinant Dog Cationic Trypsin protein (His tag) is a Dog Full Length protein, in the 24 to 246 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

TRP1, TRY1, TRYP1, PRSS1, Serine protease 1, Anionic trypsin I, Anionic trypsin-1, Beta-trypsin, Cationic trypsinogen, Pretrypsinogen I, Trypsin I, Trypsin-1

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

6x His tag N-Terminus SUMO tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P06871

Animal free

No

Carrier free

No

Species

Dog

Storage buffer

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"IVGGYTCSRNSVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSRIQVRLGEYNIAVSEGGEQFINAAKIIRHPRYNANTIDNDIMLIKLSSPATLNSRVSAIALPKSCPAAGTQCLISGWGNTQSIGQNYPDVLQCLKAPILSDSVCRNAYPGQISSNMMCLGYMEGGKDSCQGDSGGPVVCNGELQGVVSWGAGCAQKGKPGVSPKVCKYVSWIQQTIAAN","proteinLength":"Full Length","predictedMolecularWeight":"39.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":246,"aminoAcidStart":24,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P06871","tags":[{"tag":"6x His","terminus":"N-Terminus"},{"tag":"SUMO","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Cationic Trypsin also known as Trypsin-1 or PRSS1 is a serine protease enzyme with a mass of approximately 24 kDa. It exists in human pancreas in the form of inactive trypsinogen ready for secretion into the small intestine. Within the intestine trypsinogen converts into active trypsin. This enzyme cleaves peptide bonds particularly involving lysine and arginine residues and plays a critical role in protein digestion.
Biological function summary

Cationic trypsin acts to facilitate the breakdown of dietary proteins into amino acids and smaller peptides that cells can absorb. It does not act as part of a large complex but operates independently to perform its function during the digestive process. Trypsin also assists in activating other digestive enzymes such as chymotrypsinogen and procarboxypeptidase thereby amplifying its digestive function.

Pathways

Cationic trypsin plays a significant role in the proteolytic enzyme cascade that facilitates digestion within the gastrointestinal tract. It activates the zymogen forms of various enzymes including chymotrypsin and elastase so that it facilitates the complete breakdown of proteins into absorbable units. This pathway is critical for efficient nutrient absorption linking closely to other enzymes like pepsin in the stomach.

Altered activity or expression of cationic trypsin connects closely to pancreatitis particularly hereditary pancreatitis. Mutations in the PRSS1 gene result in trypsinogen that resists inactivation causing pancreas damage. Additionally it relates to certain forms of pancreatic cancer due to its role in pancreatic functions and interactions with other proteins like alpha-1 antitrypsin (SERPINA1) which normally helps in regulating trypsin activity.
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Specifications

Form

Liquid

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General info

Sequence similarities

Belongs to the peptidase S1 family.

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Product protocols

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Target data

See full target information PRSS1
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Product promise

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