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Recombinant dog Urokinase protein is a Full Length protein, in the 1 to 543 aa range, expressed in Insect, with >95% purity and suitable for SDS-PAGE, FuncS.

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Images

SDS-PAGE - Recombinant dog Urokinase protein (AB92592), expandable thumbnail

Publications

Key facts

Purity

>95% SDS-PAGE

Expression system

Insect cells

Tags

Tag free

Applications

SDS-PAGE, FuncS

Biologically active

Yes

Amino acid sequence

S H E F H P V S S A S N C S C L N G G T C V S Y K Y F S N I Q R C N C P K K F Q G E H C E I D T S K T C Y E G N G H S Y R G K A N T N T R G R P C L A W N S A A V L L K Q Y H A L R P D A L Q L G L G K H N Y C R N P D H Q R K P W C Y V Q V G L M Q L V Q E C T V Q H C S F E K N P H S P P E K A E F Q C G Q K A L R P R F K I I G G E F T T I E N Q P W F A A I Y R K H R G G S V T Y Q C G G S L I S P C W

Reactivity data

Application

SDS-PAGE

Reactivity

Reacts

Dilution info

-

Notes

-

Application

FuncS

Reactivity

Reacts

Dilution info

-

Notes

-

Associated Products

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Alternative names

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Recombinant dog Urokinase protein is a Full Length protein, in the 1 to 543 aa range, expressed in Insect, with >95% purity and suitable for SDS-PAGE, FuncS.

Key facts

Purity

>95% SDS-PAGE

Expression system

Insect cells

Applications

SDS-PAGE, FuncS

Biological activity

Active

Animal free

No

Concentration
Loading...
Storage buffer

pH: 5
Constituents: 0.58% Sodium chloride, 0.41% Sodium acetate, 0.0292% EDTA

Sequence info

Amino acid sequence

S H E F H P V S S A S N C S C L N G G T C V S Y K Y F S N I Q R C N C P K K F Q G E H C E I D T S K T C Y E G N G H S Y R G K A N T N T R G R P C L A W N S A A V L L K Q Y H A L R P D A L Q L G L G K H N Y C R N P D H Q R K P W C Y V Q V G L M Q L V Q E C T V Q H C S F E K N P H S P P E K A E F Q C G Q K A L R P R F K I I G G E F T T I E N Q P W F A A I Y R K H R G G S V T Y Q C G G S L I S P C W

Accession

Protein length

Full Length

Amino acids

1 to 543

Nature

Recombinant

Specifications

Form

Liquid

Additional notes

ab92592 is > 98% pure by SDS-PAGE.

Storage

Shipped at conditions

Dry Ice

Appropriate short-term storage conditions

-80°C

Appropriate long-term storage conditions

-80°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

This product is an active protein and may elicit a biological response in vivo, handle with caution.

Notes

Produced using non-baculovirus insect cells.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Urokinase also known as urokinase-type plasminogen activator (uPA) is a serine protease with a molecular mass of approximately 54 kDa. It is expressed in various tissues including the kidneys liver and blood vessels. Urokinase initially forms as pro-urokinase an inactive precursor that can convert into the active enzyme. Researchers often use assays like the direct assay to measure urokinase activity due to its role in breaking down fibrin and modulating cell adhesion and migration.

Biological function summary

Something particularly interesting about urokinase is its role in converting plasminogen to plasmin a critical enzyme in the process of fibrinolysis. Moreover it is part of a larger enzymatic complex involving the urokinase receptor (uPAR) which localizes plasminogen activation to cell surfaces. This complex mediates extracellular matrix degradation aiding in important cellular processes like tissue remodeling and wound healing.

Pathways

Urokinase plays a critical role in the fibrinolytic pathway which involves the breakdown of blood clots. It also interacts with the extracellular matrix pathway by activating plasminogen which can degrade matrix components. In these pathways urokinase closely interacts with proteins such as plasmin and its inhibitor plasminogen activator inhibitor-1 (PAI-1) which regulate the activity and localization of proteolytic events.

Associated diseases and disorders

Urokinase is strongly linked to conditions such as deep vein thrombosis and cancer metastasis. Its overexpression or dysregulation often leads to excessive tissue degradation influencing metastasis progression. Urokinase is connected to the urokinase receptor (uPAR) in cancer facilitating cancer cell invasion and migration. Understanding its behavior in these contexts is critical for developing therapeutic strategies and targeting treatments against these diseases.

Product promise

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1 product image

  • SDS-PAGE - Recombinant dog Urokinase protein (ab92592), expandable thumbnail

    SDS-PAGE - Recombinant dog Urokinase protein (ab92592)

    10% SDS-PAGE

    Lane 1: Urokinase (3 ug) Reduced

    Lane 2: Urokinase (3 ug) + CPAI (12 ug) Reduced

    Lane 3: Urokinase (3 ug) Non-reduced

    Lane 4: Urokinase (3 ug) + CPAI (12 ug) Non-reduced

    Lane 5: Prestained Standard

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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