Recombinant dog Urokinase protein is a Full Length protein, in the 1 to 543 aa range, expressed in Insect, with >95% purity and suitable for SDS-PAGE, FuncS.
>95% SDS-PAGE
Insect cells
Tag free
SDS-PAGE, FuncS
Yes
S H E F H P V S S A S N C S C L N G G T C V S Y K Y F S N I Q R C N C P K K F Q G E H C E I D T S K T C Y E G N G H S Y R G K A N T N T R G R P C L A W N S A A V L L K Q Y H A L R P D A L Q L G L G K H N Y C R N P D H Q R K P W C Y V Q V G L M Q L V Q E C T V Q H C S F E K N P H S P P E K A E F Q C G Q K A L R P R F K I I G G E F T T I E N Q P W F A A I Y R K H R G G S V T Y Q C G G S L I S P C W
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application FuncS | Reactivity Reacts | Dilution info - | Notes - |
Select an associated product type
PLAU
Recombinant dog Urokinase protein is a Full Length protein, in the 1 to 543 aa range, expressed in Insect, with >95% purity and suitable for SDS-PAGE, FuncS.
>95% SDS-PAGE
Insect cells
Tag free
SDS-PAGE, FuncS
Yes
Active
No
pH: 5
Constituents: 0.58% Sodium chloride, 0.41% Sodium acetate, 0.0292% EDTA
S H E F H P V S S A S N C S C L N G G T C V S Y K Y F S N I Q R C N C P K K F Q G E H C E I D T S K T C Y E G N G H S Y R G K A N T N T R G R P C L A W N S A A V L L K Q Y H A L R P D A L Q L G L G K H N Y C R N P D H Q R K P W C Y V Q V G L M Q L V Q E C T V Q H C S F E K N P H S P P E K A E F Q C G Q K A L R P R F K I I G G E F T T I E N Q P W F A A I Y R K H R G G S V T Y Q C G G S L I S P C W
Full Length
1 to 543
Recombinant
Liquid
ab92592 is > 98% pure by SDS-PAGE.
Dry Ice
-80°C
-80°C
Upon delivery aliquot
Avoid freeze / thaw cycle
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Produced using non-baculovirus insect cells.
This supplementary information is collated from multiple sources and compiled automatically.
Urokinase also known as urokinase-type plasminogen activator (uPA) is a serine protease with a molecular mass of approximately 54 kDa. It is expressed in various tissues including the kidneys liver and blood vessels. Urokinase initially forms as pro-urokinase an inactive precursor that can convert into the active enzyme. Researchers often use assays like the direct assay to measure urokinase activity due to its role in breaking down fibrin and modulating cell adhesion and migration.
Something particularly interesting about urokinase is its role in converting plasminogen to plasmin a critical enzyme in the process of fibrinolysis. Moreover it is part of a larger enzymatic complex involving the urokinase receptor (uPAR) which localizes plasminogen activation to cell surfaces. This complex mediates extracellular matrix degradation aiding in important cellular processes like tissue remodeling and wound healing.
Urokinase plays a critical role in the fibrinolytic pathway which involves the breakdown of blood clots. It also interacts with the extracellular matrix pathway by activating plasminogen which can degrade matrix components. In these pathways urokinase closely interacts with proteins such as plasmin and its inhibitor plasminogen activator inhibitor-1 (PAI-1) which regulate the activity and localization of proteolytic events.
Urokinase is strongly linked to conditions such as deep vein thrombosis and cancer metastasis. Its overexpression or dysregulation often leads to excessive tissue degradation influencing metastasis progression. Urokinase is connected to the urokinase receptor (uPAR) in cancer facilitating cancer cell invasion and migration. Understanding its behavior in these contexts is critical for developing therapeutic strategies and targeting treatments against these diseases.
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Terms & Conditions.
10% SDS-PAGE
Lane 1: Urokinase (3 ug) Reduced
Lane 2: Urokinase (3 ug) + CPAI (12 ug) Reduced
Lane 3: Urokinase (3 ug) Non-reduced
Lane 4: Urokinase (3 ug) + CPAI (12 ug) Non-reduced
Lane 5: Prestained Standard
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