Recombinant E. coli Glucokinase protein (His tag N-Terminus)
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Recombinant E. coli Glucokinase protein (His tag N-Terminus) is a Escherichia coli K-12 Full Length protein, in the 1 to 321 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
b2388, JW2385, glk, Glucokinase, Glucose kinase
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant E. coli Glucokinase protein (His tag N-Terminus) (AB183231)
15% SDS-PAGE analysis of ab183231 (3μg).
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Glucokinase acts as a glucose sensor regulating blood sugar levels and insulin secretion. This process does not involve the enzyme as part of a larger complex. Instead glucokinase functions independently to sense glucose concentrations and adjusts the rate of glucose phosphorylation accordingly. Its activity significantly affects the balance of glucose uptake and energy production especially during postprandial states when glucose levels rise. Glucokinase activity is therefore important to maintaining glucose homeostasis.
Pathways
Glucokinase plays a central role in the glycolytic pathway and interacts with the insulin signaling pathway. Within these pathways it influences how the liver stores glucose as glycogen and controls insulin release from pancreatic beta-cells. Glucokinase activity is modulated by glucose levels and is closely related to insulin receptor substrates that affect downstream insulin signaling. Its function is important for the proper regulation of these pathways linking glucose sensing with metabolic control in varied tissues.
Specifications
Form
Liquid
Additional notes
ab183231 was purified using conventional chromatography techniques.
General info
Function
An ATP-dependent kinase that phosphorylates glucose to make glucose-6-phosphate, not active on fructose, galactose or mannose. Not highly important in wild-type E.coli as glucose is transported into the cell by the PTS system as glucose 6-phosphate.
Sequence similarities
Belongs to the bacterial glucokinase family.
Target data
Complementary Products
Product promise
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