Recombinant E. coli Glyoxylate/hydroxypyruvate reductase A (ghrA) protein (His tag)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

The enzyme catalyzes reactions that are part of metabolic pathways associated with the disposal of glyoxylate minimizing its accumulation to prevent cellular damage. While ghrA does not typically form part of a larger protein complex it functions in coordination with other enzymes involved in glycolate and glycerate metabolism. Its activity is critical to maintaining metabolic homeostasis especially in tissues with high metabolic demands.

Pathways

GhrA functions within the glyoxylate and dicarboxylate metabolism pathway. This pathway is essential for converting toxic glyoxylate into non-toxic metabolites thereby preventing potential harmful effects. ghrA works with enzymes like glycolate oxidase in the glyoxylate detoxification process. Additionally it plays a role in the serine metabolic pathway providing a connection to enzymes such as serine dehydratase which aids in amino acid metabolism.