Recombinant E. coli nanA protein (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

NanA exhibits a significant role in facilitating bacterial colonization and infection propagation. By removing sialic acids it exposes underlying receptors on host cell membranes which pathogens can then exploit for attachment and invasion. NanA does not typically function within a larger enzymatic complex but it is key in disrupting host cell integrity and immune recognition increasing microbial evasion capabilities. This makes nanA a potential target for therapeutic intervention to mitigate infections.

Pathways

The enzymatic function of nanA connects directly to paths involving host-pathogen interactions. In particular it engages in pathways important for bacterial adhesion and invasion of host tissues. This protein works alongside other bacterial virulence factors such as pneumolysin which further compromises host defenses and tissue integrity. These interactions highlight nanA's involvement in both initial stages of infection and progression within the host body.