JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB236921

Recombinant E. coli Outer membrane protein C (His tag)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant E. coli Outer membrane protein C (His tag) is a Escherichia coli K-12 Full Length protein, in the 22 to 367 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

meoA, par, b2215, JW2203, ompC, Outer membrane porin C, Outer membrane protein 1B, Outer membrane protein C, Porin OmpC

1 Images
SDS-PAGE - Recombinant E. coli Outer membrane protein C (His tag) (AB236921)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant E. coli Outer membrane protein C (His tag) (AB236921)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) analysis with 5% enrichment gel and 15% separation gel of ab236921.

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P06996

Animal free

No

Carrier free

No

Species

Escherichia coli K-12

Storage buffer

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

style
left-column

Complementary Products

Reagents, Controls & Accessories

AB234617

Prestained Protein Ladder - Mid-range molecular weight (10 - 180 kDa)

SDS-PAGE - Prestained Protein Ladder - Mid-range molecular weight (10 - 180 kDa) (AB234617)

  • 0
  • 0
Proteins & Peptides

AB236164

Recombinant Pseudomonas aeruginosa ompF protein (His tag)

SDS-PAGE - Recombinant Pseudomonas aeruginosa ompF protein (His tag) (AB236164)

  • 0
  • 0
Primary Antibodies

AB183947

Anti-Olfactory Marker Protein/OMP antibody [EPR19190]

RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Olfactory Marker Protein/OMP antibody [EPR19190] (AB183947)

  • 4
  • 2
Proteins & Peptides

AB259412

Recombinant human VEGF 165A protein (Active)

Premium Bioactive

Mass Spectrometry - Recombinant human VEGF 165A protein (Active) (AB259412)

  • 0
  • 0
Proteins & Peptides

AB271721

Recombinant human PRMT5 + MEP50 protein (Active) (DDDDK tag N-Terminus, His tag N-Terminus)

Functional Studies - Recombinant human PRMT5 + MEP50 protein (Active) (DDDDK tag N-Terminus, His tag N-Terminus) (AB271721)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"AEVYNKDGNKLDLYGKVDGLHYFSDNKDVDGDQTYMRLGFKGETQVTDQLTGYGQWEYQIQGNSAENENNSWTRVAFAGLKFQDVGSFDYGRNYGVVYDVTSWTDVLPEFGGDTYGSDNFMQQRGNGFATYRNTDFFGLVDGLNFAVQYQGKNGNPSGEGFTSGVTNNGRDALRQNGDGVGGSITYDYEGFGIGGAISSSKRTDAQNTAAYIGNGDRAETYTGGLKYDANNIYLAAQYTQTYNATRVGSLGWANKAQNFEAVAQYQFDFGLRPSLAYLQSKGKNLGRGYDDEDILKYVDVGATYYFNKNMSTYVDYKINLLDDNQFTRDAGINTDNIVALGLVYQF","proteinLength":"Full Length","predictedMolecularWeight":"42.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":367,"aminoAcidStart":22,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P06996","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Outer membrane protein C also known as OmpC protein is a significant component of the outer membrane in Gram-negative bacteria particularly E. coli. This protein with a mass of approximately 40 kDa spans the outer membrane and acts as a porin. It facilitates the selective transport of small molecules and ions into and out of the bacterial cell playing an important role in maintaining the cellular homeostasis. OmpC is abundantly expressed in the outer membrane of E. coli where it forms trimeric complexes contributing to the permeability barrier of the membrane.
Biological function summary

Outer membrane protein C contributes to the osmotic balance of E. coli cells. It adjusts the permeability of the outer membrane under different environmental conditions such as changes in osmolarity. OmpC forms trimeric structures working in concert with other porins like OmpF to modulate the membrane's permeability to various solutes. This ability to regulate solute passage is important for the bacteria's adaptive responses allowing E. coli to thrive in fluctuating environments.

Pathways

Outer membrane protein C plays a significant role in the regulation of osmotic stress pathways in E. coli. OmpC alongside porins like OmpF and LamB is an important player in these pathways adapting its expression and function in response to changing osmotic conditions. This regulation is essential for the effective transport of metabolites and ions impacting the larger metabolic networks within the bacterium. It influences pathways involved in nutrient uptake which are vital for bacterial survival and adaptation.

Outer membrane protein C has implications in the pathogenesis of certain infections like urinary tract infections (UTIs) caused by E. coli. Variations in the expression of OmpC along with proteins such as TolC can affect the bacterium’s resistance to antibiotics. This resistance arises from changes in membrane permeability that can influence antibiotic uptake presenting challenges for treatment. Understanding OmpC's role in such infections is essential for developing more effective therapeutic strategies.
style
left-column

Specifications

Form

Liquid

style
left-column

General info

Function

Forms pores that allow passive diffusion of small molecules across the outer membrane.. (Microbial infection) Supports colicin E5 entry in the absence of its major receptor OmpF.. (Microbial infection) A mixed OmpC-OmpF heterotrimer is the outer membrane receptor for toxin CdiA-EC536; polymorphisms in extracellular loops 4 and 5 of OmpC confer susceptibility to CdiA-EC536-mediated toxicity.

Sequence similarities

Belongs to the Gram-negative porin family.

style
left-column

Product protocols

style
left-column

Target data

Forms pores that allow passive diffusion of small molecules across the outer membrane.. (Microbial infection) Supports colicin E5 entry in the absence of its major receptor OmpF.. (Microbial infection) A mixed OmpC-OmpF heterotrimer is the outer membrane receptor for toxin CdiA-EC536; polymorphisms in extracellular loops 4 and 5 of OmpC confer susceptibility to CdiA-EC536-mediated toxicity.
See full target information ompC
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com