Recombinant E. coli Thioredoxin reductase protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

Thioredoxin reductase participates in several critical cellular processes beyond just reducing substrates. It acts as an important player in antioxidant defense cellular signaling and apoptosis. As part of the thioredoxin system which often works closely with other antioxidant systems it plays a role in detoxifying harmful reactive oxygen species. It is not typically part of larger protein complexes but interacts functionally with many proteins to regulate redox signaling pathways.

Pathways

Thioredoxin reductase engages in the regulation of redox signaling and is active in the thioredoxin system pathway. This pathway plays an important role in controlling enzymatic processes that guard cells against oxidative stress. Thioredoxin reductase is also involved in the NADPH-dependent thioredoxin system alongside thioredoxin and NADPH. The enzyme is correlated with the activity of glutathione peroxidase emphasizing its role in redox balance within the cell.