Recombinant EBV gp340/220 Envelope Protein (Tagged)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

This glycoprotein promotes viral entry by enhancing the fusion between the viral envelope and the host cell membrane. It is an important component of the viral entry machinery acting in conjunction with other viral proteins such as gp42 to initiate infection. It functions as part of a greater complex that mediates the initial stages of infection enabling the virus to establish itself in resting B cells and epithelial cells. By allowing the attachment and initial colonization of host cells EBV gp340/220 serves as an important facilitator of EBV's life cycle.

Pathways

EBV gp340/220 plays a substantial role in the viral infection process and influences pathways like the complement pathway and B cell activation pathway. It interacts prominently with CD21 a receptor on B cells to trigger the internalization of the virus. This interaction forms a basis for activating signaling pathways inside the host cell subsequently leading to events that promote viral replication and latent infection. Although gp350/220 remains distinct its functions influence other viral proteins such as LMP1 in downstream signaling pathways which contribute to virus persistence and oncogenesis.