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AB43141

Recombinant EBV protein

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Recombinant EBV protein is a Epstein-Barr Virus (Strain B95-8) Fragment protein, expressed in Escherichia coli, with >95%, suitable for ELISA, WB.

View Alternative Names

BKRF2, gL, Envelope glycoprotein L

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

Tag free

Applications

WB, ELISA

applications

Biologically active

No

Accession

P03212

Animal free

No

Carrier free

No

Species

Epstein-Barr Virus (Strain B95-8)

Storage buffer

Constituents: 50% Glycerol (glycerin, glycerine), 0.79% Tris HCl, 0.5% Sodium-N-Lauroylsarcosinate, 0.348% Sodium chloride, 0.307% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p>Excellent antigen for detection of EBV (HHV4) with minimal specificity problems.</p>" } } }
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Sequence info

[{"sequence":"","proteinLength":"Fragment","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":0,"aminoAcidStart":0,"nature":"Recombinant","expressionSystem":null,"accessionNumber":"P03212","tags":[]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
-20°C
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Epstein-Barr Virus (EBV) also known as Human herpesvirus 4 is a double-stranded DNA virus with a mass of approximately 172 kDa. It belongs to the herpesvirus family and has a tropism for B lymphocytes as well as epithelial cells. EBV can persist in latent form within host cells and reactivate under certain conditions. The virus expresses several proteins during its lytic and latent infection stages contributing to its ability to manipulate host cellular machinery.
Biological function summary

Epstein-Barr Virus impacts multiple cellular processes altering cell cycle regulation and modulating immune responses. EBV expresses latency-associated proteins such as EBNA (Epstein-Barr Nuclear Antigen) and LMP (Latent Membrane Protein) which help maintain its latent state and contribute to cell transformation. These proteins are part of larger complexes that interact with host cellular pathways to secure viral persistence and evade immune detection.

Pathways

The Epstein-Barr Virus impacts cell proliferation and survival pathways. It influences the NF-kB pathway promoting cell survival and proliferation. The virus also interacts with the PI3K-AKT pathway which regulates several cellular functions such as metabolism and cell growth. Through these pathways proteins like TRAF (TNF receptor-associated factor) become involved helping the virus to manipulate host cell functions for its benefit.

Epstein-Barr Virus is associated with infectious mononucleosis and several forms of cancer including Burkitt's lymphoma and nasopharyngeal carcinoma. The virus maintains a connection with oncogenic processes through interactions with proteins like c-Myc in the case of Burkitt's lymphoma promoting cell proliferation and neoplastic transformation. EBV's role in disease highlights the complexity of its interactions within the host and its ability to contribute to disease pathogenesis.
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Specifications

Form

Liquid

Additional notes

Sepharose-Derived Purification determined by 10% PAGE (coomassie staining).

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General info

Function

The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH. Fusion of EBV with B-lymphocytes requires the additional receptor-binding protein gp42, which forms a complex with gH/gL. The heterodimer gH/gL targets also host EPHA2 to promote viral entry.

Sequence similarities

Belongs to the herpesviridae glycoprotein L family.

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Product protocols

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Target data

The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH. Fusion of EBV with B-lymphocytes requires the additional receptor-binding protein gp42, which forms a complex with gH/gL. The heterodimer gH/gL targets also host EPHA2 to promote viral entry.
See full target information gL
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