Recombinant Follistatin (FS) is a Human Fragment protein, in the 35 to 283 aa range, expressed in Escherichia coli, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.
View Alternative Names
Follistatin, FS, Activin-binding protein, FST
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Follistatin (FS) (AB316919)
Recombinant Follistatin (FS) Human, 15% SDS PAGE. Predicted Molecular Mass : 31.3kDa, Accurate Molecular Mass : 33kDa as determined by SDS-PAGE reducing conditions.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Follistatin modulates multiple processes such as cell growth differentiation and reproductive physiology. It acts as a binding protein for activin neutralizing its activity. By preventing activin from engaging with its receptor complexes follistatin influences developmental and regenerative processes. Despite not being a part of a transmembrane complex its interaction with activin impacts extracellular interactions.
Pathways
Follistatin plays a significant role in the regulation of the TGF-β signaling pathway and the muscle growth pathway. In the TGF-β pathway it counteracts the signaling of activin which influences cellular homeostasis and inflammatory responses. In the muscle growth pathway follistatin interferes with myostatin another member of the TGF-β family promoting muscle growth. This cross-talk with proteins such as myostatin demonstrates follistatin's influence in muscle regeneration and development.
Specifications
Form
Lyophilized
General info
Function
Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).
Target data
Complementary Products
![Western blot - Anti-Follistatin antibody [EPR10903] (AB157471)](https://content.abcam.com/products/images/follistatin-antibody-epr10903-ab157471--western-blot-img17921.jpg)
Product promise
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