Recombinant Gingipain R1 protein (His tag)
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(4 Publications)
Recombinant Gingipain R1 protein (His tag) is a Porphyromonas gingivalis Fragment protein, in the 228 to 720 aa range, expressed in Yeast, with >90%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
rgp1, rgpA, Gingipain R1, Arg-gingipain, Gingipain 1, RGP-1
- Mass Spec
Supplier Data
Mass Spectrometry - Recombinant Gingipain R1 protein (His tag) (AB225982)
Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS analysis result of ab225982 could indicate that this peptide derived from Yeast-expressed Porphyromonas gingivalis Gingipain R1.
- Mass Spec
Supplier Data
Mass Spectrometry - Recombinant Gingipain R1 protein (His tag) (AB225982)
Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS analysis result of ab225982 could indicate that this peptide derived from Yeast-expressed Porphyromonas gingivalis Gingipain R1.
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Gingipain R1 protein (His tag) (AB225982)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) analysis of ab225982 with 5% enrichment gel and 15% separation gel.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Gingipain R1 acts as a potent virulence factor of Porphyromonas gingivalis by aiding the invasion and destruction of periodontal tissues. It is known to be part of a larger proteolytic complex which enhances its enzymatic activity and stability. Gingipains degrade extracellular matrix proteins and modulate the host immune response allowing the bacteria to evade immune mechanisms. This protease can activate inflammatory cytokines through the cleavage of cell surface components amplifying inflammatory processes in the host tissue.
Pathways
Gingipain R1 contributes significantly to the coagulation pathway by modulating fibrinogen and fibrin. It also affects the complement pathway indirectly inhibiting complement-mediated immune responses via degradation of complement proteins. Gingipain R1 interaction with other bacterial proteins such as hemagglutinin further strengthens its functional role in these pathways facilitating pathogenic interactions with the host.
Specifications
Form
Liquid
General info
Function
Thiol protease. Acts synergistically with RgpB to catalyze the maturation of fimbrial subunits, such as FimA (By similarity). Its proteolytic activity is a major factor in both periodontal tissue destruction and in evasion of host defense mechanisms (Probable).
Sequence similarities
Belongs to the peptidase C25 family.
Target data
Publications (4)
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Signal transduction and targeted therapy 10:171 PubMed40404630
2025
Applications
Unspecified application
Species
Unspecified reactive species
BMC cancer 24:534 PubMed38671413
2024
Applications
Unspecified application
Species
Unspecified reactive species
Frontiers in immunology 11:1551 PubMed32793214
2020
Applications
Unspecified application
Species
Unspecified reactive species
Frontiers in aging neuroscience 11:210 PubMed31507404
2019
Applications
Unspecified application
Species
Unspecified reactive species
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