Recombinant Hepatitis E Virus ORF2 antigen protein is a Hepatitis E virus (strain Burma) protein, in the 403 to 461 aa range, expressed in Escherichia coli, with >95% purity and suitable for ELISA, WB.
S A N G E P T V K L Y T S V E N A Q Q D K G I A I P H D I D L G E S R V V I Q D Y D N Q H E Q D R P T P S P A P S R P
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Isoform Secreted protein ORF2. Plays a role in the inhibition of host antibody-mediated neutralization without blocking viral cell entry. Isoform Capsid protein. Forms an icosahedral capsid with a T=1 symmetry and a 34 nm diameter. The capsid is composed of 60 copies linked to each other. Binds to the 5' end of the genomic RNA to mediate genome encapsidation (PubMed:14671114, PubMed:15557331). Binds to heparin surface proteoglycans (HSPGs) to mediate viral entry (By similarity). Additionally, the interactions with host ASGR1 and ASGR2 facilitate viral infection of hepatocytes (By similarity). Inhibits IFN production by blocking host TBK1-induced IRF3 phosphorylation (By similarity). The nuclear form probably modulates host gene expression (By similarity).
ORF2, Hepatitis E Virus ORF2 antigen, ORF2, ORF2
Pro-secreted protein ORF2, Protein ORF2, pORF2, ORF2
Recombinant Hepatitis E Virus ORF2 antigen protein is a Hepatitis E virus (strain Burma) protein, in the 403 to 461 aa range, expressed in Escherichia coli, with >95% purity and suitable for ELISA, WB.
pH: 7.2 - 7.6
Constituents: 48% Urea, 0.316% Tris HCl, 0.078% 2-Mercaptoethanol
Isoform Secreted protein ORF2
Belongs to the hepevirus capsid protein family.
Pro-secreted protein ORF2
The Hepatitis E Virus ORF2 antigen also known as the ORF2 protein is the major capsid protein of the hepatitis E virus (HEV). It plays an important role in forming the viral particle and is approximately 60 kDa in mass. ORF2 protein is expressed primarily in infected hepatocytes but viral shedding studies detect it in bodily fluids like feces and blood serum during HEV infection. Viral structural proteins like the ORF2 protein are essential for understanding HEV assembly and transmission.
The ORF2 protein facilitates essential processes in the HEV life cycle. It encompasses virus attachment entry and eventually the encapsidation of the viral RNA. This protein is involved in forming a protective layer around the viral genetic material playing a critical role in host immune evasion. The ability of ORF2 to form virus-like particles makes it a significant component in vaccine development and serological assays intended for hepatitis E diagnosis.
ORF2 protein participates actively in pathways related to HEV capsid assembly and virus-host interaction. Its functions intersect with the immune response evasion mechanisms where it interacts with host cellular proteins to help the virus elude immune detection. The ORF2 is often studied alongside other HEV proteins such as ORF3 which aids in viral particle release reflecting their collaborative roles in ensuring efficient viral propagation and survival within the host.
The Hepatitis E Virus ORF2 antigen is directly linked to hepatitis E often associated with acute liver inflammation. The interaction of ORF2 protein with host immune components is important in the disease's progression leading to symptoms like jaundice and liver dysfunction. Research into ORF2 also examines its relationship with other hepatotropic viruses assessing the cross-reactivity or co-infection potential especially in hepatitis B and C. Understanding these interactions enhances strategies for therapeutic developments and vaccine production against hepatitis E and related viral hepatitis infections.
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