Recombinant HIV1 gp140 protein (Fc Chimera)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

The gp140 protein engages in forming a trimeric complex which is important for its function in viral entry. This complex interacts with the CD4 receptor and a coreceptor typically either CCR5 or CXCR4 on the surface of target cells. This interaction enables the virus to fuse with the host cell membrane initiating infection. Gp140's structure and binding capabilities significantly contribute to its role in evading host immune responses as it can shield key epitopes from neutralizing antibodies. This evasion mechanism poses challenges for immune recognition and is an important factor in the persistence and progression of HIV infection.

Pathways

The HIV gp140 protein is intricately involved in the HIV life cycle and viral entry pathways. It's associated with signal transduction pathways that activate after binding to CD4 receptor and coreceptors like CCR5 or CXCR4. These interactions lead to conformational changes necessary for fusion. The binding of gp140 to the CD4 receptor also interacts with other proteins such as Lck which further transmits signals that facilitate viral entry. The viral entry process highlights the sophisticated tactics the virus uses to establish infection and maintain replication within host cells.